|
rs10759931
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An MDR analysis of gene-gene and gene-environment interactions identified three SNPs (rs10759932, rs7873784, and rs10759931) that predicted LTBI with 84% accuracy (p = 0.0004) and three SNPs (rs3804100, rs1898830, and rs10759931) that predicted PTB with 80% accuracy (p = 0.0001).
|
25928077 |
2015 |
|
rs10995271
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we identified an association with borderline significance (P = 0.0009433 and P = 0.029 after multiple testing by Bonferroni's correction) of SNP rs10995271 with PTB.
|
24365559 |
2014 |
|
rs1568952
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We thus identified around rs1568952 and rs2726600 a cluster of SNPs strongly associated with early-onset PTB in Morocco and Madagascar.
|
23415668 |
2013 |
|
rs2737190
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of rs10759932 and rs2737190 in TLR4 are significantly related to both COPD and PTB but with inverse effects.
|
31640653 |
2019 |
|
rs4331426
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the results of this study do not support an association between the rs4331426 polymorphism and risk of PTB in an Iranian population.
|
27554121 |
2016 |
|
rs4788172
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association fit a recessive genetic model and was greater for TBM than for PTB (for TBM: rs4788172, odds ratio [OR], 1.64; 95% confidence interval [CI], 1.04-2.59, rs17842268 [OR, 2.20; 95% CI, 1.29-3.76, and rs12596308 [OR, 2.38; 95% CI, 1.47-3.89]).
|
25078322 |
2015 |
|
rs6507226
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped four genetic variants at 8q24 (rs10956514 and rs11774633) and 18q11.2 (rs4331426 and rs6507226) in a case-control study with 355 newly bacteriologically confirmed pulmonary TB cases and 395 healthy controls using TaqMan allelic discrimination assay.
|
26964908 |
2016 |
|
rs7194886
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, genetic polymorphisms of the SNP rs7194886 in the NOD2 gene, which were discovered in the GWAS of leprosy, might also be associated with the pulmonary tuberculosis in the Chinese population.
|
22212192 |
2012 |
|
rs9271300
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped two genetic variants (rs9272461 and rs9271300) on the reported chromosome 6p21 in 739 pulmonary tuberculosis (PTB) cases and 749 healthy controls from Chinese Han population using TaqMan allelic discrimination assay.
|
29933081 |
2018 |
|
rs4988453
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs TLR9 rs352139, TLR2 rs3804099 and MYD88 rs4988453 were associated with PTB in females (OR = 0.49, p = 0.0009; OR = 0.51, p = 0.0008; OR = 0.33, p = 0.027; here and below log-additive model with minor alleles assumed as effect associated alleles), while SNP TLR8 rs3764880 showed a significant association in males (OR = 0.44, p = 0.0087).
|
30529560 |
2019 |
|
rs1042713
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype distributions of the rs1042713 (Arg16Gly +46A>G) and rs1042714 (Gln27Glu +79C>G) polymorphisms in ADRB2 gene in 106 patients with pulmonary tuberculosis and 88 healthy subjects were studied by PCR-RFLP method in an Iranian population.
|
27900465 |
2017 |
|
rs1042714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype distributions of the rs1042713 (Arg16Gly +46A>G) and rs1042714 (Gln27Glu +79C>G) polymorphisms in ADRB2 gene in 106 patients with pulmonary tuberculosis and 88 healthy subjects were studied by PCR-RFLP method in an Iranian population.
|
27900465 |
2017 |
|
rs1800870
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based upon the functional role of the TNF-α [-308 G(low) → A(high) (rs1800629)] and IL-10 [-1082 A(low) → G(high) (rs1800870), -819 T(low) → C(high) (rs1800871) and -592 A(low) → C(high) (rs1800872)] single nucleotide polymorphisms (SNPs) on production levels, we genotyped 76 patients with pulmonary tuberculosis (TB) (pTB), 55 patients with extrapulmonary TB (epTB) and 95 healthy blood donors by polymerase chain reaction fragment length polymorphism (PCR-RFLP).
|
21609779 |
2011 |
|
rs15493
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the <i>VTI1B</i> rs15493 SNP had no impact on the susceptibility to PTB (<i>p</i> > 0.05).
|
30945947 |
2019 |
|
rs56061981
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Regulatory role of CCL5 (rs2280789) and CXCL10 (rs56061981) gene polymorphisms on intracellular CCL5 and CXCL10 expression in pulmonary tuberculosis.
|
28336310 |
2018 |
|
rs2072069
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study was to evaluate the possible association between CCL1 rs2072069 G/A or/and TLR2 rs3804099 T/C (T597C) polymorphisms and pulmonary tuberculosis (PTB) or/and tuberculous meningitis (TBM) in a sample of the Chinese adult population.
|
26722451 |
2015 |
|
rs2280789
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Regulatory role of CCL5 (rs2280789) and CXCL10 (rs56061981) gene polymorphisms on intracellular CCL5 and CXCL10 expression in pulmonary tuberculosis.
|
28336310 |
2018 |
|
rs1799864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CCR2 V64I (G/A), monocyte chemoattractant protein-1 (MCP-1) -2518 A/G, stromal cell derived factor-1alpha; (SDF-1alpha) 3'UTR G/A and DC-SIGN gene polymorphisms were studied by polymerase chain reaction based methods in HIV-1 infected patients without TB (n=151), with pulmonary TB (PTB) (n=81) and extrapulmonary TB (n=31), 155 PTB patients without HIV and 206 healthy controls.
|
19942750 |
2009 |
|
rs373950030
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CCR2 V64I (G/A), monocyte chemoattractant protein-1 (MCP-1) -2518 A/G, stromal cell derived factor-1alpha; (SDF-1alpha) 3'UTR G/A and DC-SIGN gene polymorphisms were studied by polymerase chain reaction based methods in HIV-1 infected patients without TB (n=151), with pulmonary TB (PTB) (n=81) and extrapulmonary TB (n=31), 155 PTB patients without HIV and 206 healthy controls.
|
19942750 |
2009 |
|
rs4804803
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggest that CD209 rs4804803 polymorphism increased the risk of PTB in a sample of Iranian population.
|
23751770 |
2014 |
|
rs10499859
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data showed that MARCO rs12998782 may increase PTB risk while two SNPs of CD36, rs1194182 and rs10499859 may reduce the risk, indicating MARCO and CD36 as important receptors in response to PTB.
|
28693442 |
2017 |
|
rs1194182
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data showed that MARCO rs12998782 may increase PTB risk while two SNPs of CD36, rs1194182 and rs10499859 may reduce the risk, indicating MARCO and CD36 as important receptors in response to PTB.
|
28693442 |
2017 |
|
rs3211956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs17009726 and rs3211956 were not associated with susceptibility/resistance to PTB.
|
28693442 |
2017 |
|
rs3092923
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CD40LG rs3092923 and its combined effects with the other two SNPs were associated with an increased risk of pTB only in males.
|
26043172 |
2015 |
|
rs2239751
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant association was observed between CISH rs2239751 polymorphism and risk/protection of PTB.
|
27266592 |
2017 |