|
rs17235409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
NRAMP1 D543N and INT4 polymorphisms in susceptibility to pulmonary tuberculosis: A meta-analysis.
|
28648687 |
2017 |
|
rs17235409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In further stratified analyses by ethnicity and TB forms, significant increased risks were found in subgroups of Asians and in pulmonary TB (PTB) for all four polymorphisms, while an increased risk of extra-pulmonary TB (EPTB) was found for D543N polymorphism.
|
22326178 |
2012 |
|
rs17235409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The distribution of 3'-UTR and D543N polymorphisms in 223 TB patients (168 patients with pulmonary TB (PTB) and 55 patients with extrapulmonary TB (EPTB)) and 150 healthy donors was determined by PCR-restriction fragment length polymorphism (RFLP) method.
|
22609013 |
2012 |
|
rs17235409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
NRAMP1 polymorphisms (3'UTR, D543N, INT4) were evaluated among 142 patients with culture-positive pulmonary tuberculosis and 144 ethnically matched healthy controls having latent M. tuberculosis infection.
|
21169917 |
2011 |
|
rs17235409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Using polymerase chain reaction and the restriction fragment-length polymorphism analyses, we investigated four previously reported SLC11A1 polymorphisms, variations in 5'(GT)n, INT4, D543N, and 3'UTR in 95 patients with pulmonary tuberculosis including 10 MDR-TB patients.
|
17950034 |
2008 |
|
rs17235409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
No association of other polymorphisms (NRAMP1 D543N, TNF-alpha-308) and susceptibility to silicosis or PTB in Chinese miners was found.
|
17223386 |
2007 |
|
rs17235409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To explore the potential role of these genes in the susceptibility to pulmonary tuberculosis in a Mexican mestizo population, we evaluated the association of D543N and 3'-UTR polymorphisms in NRAMP1/SLC11 A1 and - 762 and A1513C polymorphisms in P2X(7) genes with the risk for tuberculosis.
|
17493019 |
2007 |
|
rs17235409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
INT4-D543N-3'UTR haplotypes showed an association with pulmonary TB (P=0.03).
|
16461017 |
2006 |
|
rs17235409
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To test this possibility, we examined NRAMP1 variants at the INT4 and D543N loci, as well as their association with severe forms of pulmonary tuberculosis, in 127 patients with active pulmonary tuberculosis and in 91 ethnically matched, healthy control subjects in areas of China where tuberculosis is endemic.
|
15825023 |
2005 |
|
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
(3) Stratified by sample type, TLR2 Arg753Gln polymorphism is associated with increased PTB risk, but not with EPTB.
|
30733958 |
2019 |
|
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Genotyping was performed to detect -196 to -174 del polymorphism and G2258A SNP (Arg753Gln, rs5743708) in TLR2 gene and -T1237C (rs5743836) and G2848A (rs352140) SNP in TLR9 gene in patients with pulmonary TB and healthy controls.
|
29675696 |
2018 |
|
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
There was a significant association between the GA genotype (heterozygous mutant) of TLR2 Arg753Gln polymorphism and the risk of infection with pulmonary TB (p = 0.003, OR = 4.83) and TB peritonitis (p = 0.003, OR = 6.2).
|
28332241 |
2017 |
|
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In TLR2, the frequencies of the CC genotype (OR = 2.262; 95% CI: 1.433-3.570) and C allele (OR = 1.566; 95% CI: 1.223-1.900) in single-nucleotide polymorphism (SNP) rs3804100 were significantly higher in the LTBI group than in the HC group, whereas the GA genotype of SNP rs5743708 was associated with PTB (OR = 6.087; 95% CI: 1.687-21.968).
|
25928077 |
2015 |
|
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A meta-analysis was conducted to investigate the relationship between TLR2 G2</span>258A and T597C polymorphisms with PTB susceptibility.
|
24124467 |
2013 |
|
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We also showed that the frequencies of the heterozygous Arg753Gln genotype and the Gln allele were significantly higher in patients with pulmonary TB alone and in patients with definitive pulmonary plus extrapulmonary TB than in children with LTBI.
|
21320563 |
2011 |
|
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB).
|
20797905 |
2010 |
|
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether the functional genetic variations at position 1805 G/T in TLR1, 2258 A/G in TLR2, -857 C/T, and -863 A/C in tumor necrosis factor-α (TNF-α), as well as -819 C/T in interleukin-10 (IL-10) confer susceptibility to pulmonary tuberculosis (PTB).
|
20650298 |
2010 |
|
rs4986790
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Furthermore, SNPs TLR9 rs352139 and TLR8 rs3764880 were associated with PTB in the late-onset (≥39-year-old) patient group (OR = 0.60, p = 0.0029 and OR = 0.70, p = 0.021, respectively) and SNPs TLR2 rs3804099, TLR4 rs4986790 and TLR4 rs1927906 in the early-onset (≤ 38-year-old) group (OR = 0.53, p = 0.0012; OR = 3.45, p = 0.013; OR = 2.31, p = 0.044, respectively).
|
30529560 |
2019 |
|
rs4986790
|
|
|
0.060 |
GeneticVariation |
BEFREE |
BACKGROUND Findings regarding the association of the single-nucleotide polymorphisms (SNPs) rs4986790 and rs4986791 in Toll-like receptor 4 and rs187084, rs574386, and rs352139 in Toll-like receptor 9 (TLR9) with pulmonary tuberculosis (PTB) susceptibility are inconsistent.
|
25889916 |
2015 |
|
rs4986790
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Human Toll-like receptor 4 polymorphisms TLR4 Asp299Gly and Thr399Ile influence susceptibility and severity of pulmonary tuberculosis in the Asian Indian population.
|
20403143 |
2010 |
|
rs4986790
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB).
|
20797905 |
2010 |
|
rs4986790
|
|
|
0.060 |
GeneticVariation |
BEFREE |
No association between TLR4 Asp299Gly and pulmonary TB was found.
|
18008256 |
2007 |
|
rs4986790
|
|
|
0.060 |
GeneticVariation |
BEFREE |
To determine whether TLR4 Asp299Gly influences LPS responses or susceptibility to pulmonary TB in humans in a Gambian population sample.
|
15525557 |
2004 |
|
rs3804099
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Polymorphisms rs3804099 (TLR2) and rs352139 (TLR9) may also be associated with PTB risk in the Moldavian population but their effect is less consistent across different studies.
|
30529560 |
2019 |
|
rs2476601
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We found that the T allele of rs2476601 and the A allele of rs33996649within <i>PTPN22</i> gene, interaction between rs2476601 and T2DM were all associated with increased PTB risk.
|
29029456 |
2017 |