|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The ADH1B genotype was associated with the frequency and volume of drinking but its associations with binge drinking and problem drinking were less consistent.
|
22150722 |
2012 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
CTD_human |
Acetaldehyde, polymorphisms and the cardiovascular system.
|
17590986 |
2007 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
We genotyped the rs1229984 G→A variant of the alcohol dehydrogenase 1B (ADH1B) gene, which is associated with lower prevalence of alcohol abuse and dependence.
|
24553426 |
2014 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
CTD_human |
Variation in the ADH1B proximal promoter affects expression.
|
21168396 |
2011 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Given the logistic and ethical constraints that would be associated with a trial of alcohol use to prevent depression, we aimed to complete a Mendelian randomization study to determine if a genetic polymorphism associated with alcohol abuse and dependence (ADH1B rs1229984 G-->A) contributed to modulate the risk of depression in a community-derived cohort of older men.
|
24018899 |
2014 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
CTD_human |
Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action.
|
16404797 |
2005 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The ADH1B gene has consistently been implicated in problem drinking, but rarely incorporated into gene by environment investigations of alcohol phenotypes.
|
25410943 |
2014 |
|
Alcohol Use Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
Acetaldehyde, polymorphisms and the cardiovascular system.
|
17590986 |
2007 |
|
Alcohol Use Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action.
|
16404797 |
2005 |
|
Alcohol Use Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
Variation in the ADH1B proximal promoter affects expression.
|
21168396 |
2011 |
|
Alcoholic Intoxication
|
0.310 |
Biomarker
|
disease |
PSYGENET |
This suggests that drunk drivers with augmented MCV modulated by the alcohol metabolic ADH1B*1/*1 genotype may be at higher risk of driving incapability and of alcohol-related cancer.
|
21917409 |
2012 |
|
Alcoholic Intoxication
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Higher responses on the SHAS items muddle/confused and nauseated were significantly associated with the presence of at least one ADH1B*3 allele following the high dose of alcohol in Afro-T. Indo-T with at least one ADH1C*2 allele displayed significantly different Drug × Time interactions for the SHAS item effects of alcohol at the low dose and for the SHAS items clumsy, muddle/confused, effects of alcohol, floating, drunk, and total at the high dose from Indo-T with two ADH1C*1 alleles.
|
25208201 |
2014 |
|
Alcoholic Intoxication
|
0.310 |
Biomarker
|
disease |
PSYGENET |
In subgroup analyses according to smoking and alcohol drinking status, the OR of the ADH1B*1*1 genotype was increased in the heavy drinker group [8.85 (1.095-40.0)] and in the heavy smoker group [4.7 (1.54-14.29)].
|
21576033 |
2011 |
|
Alcoholic Intoxication
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Gene-environment interactions on the risk of esophageal cancer among Asian populations with the G48A polymorphism in the alcohol dehydrogenase-2 gene: a meta-analysis.
|
24446180 |
2014 |
|
Alcoholic Intoxication
|
0.310 |
Biomarker
|
disease |
PSYGENET |
The longer-than-expected EtOH lingering in the blood of the ADH1B*1/*1 alcoholics may exacerbate alcohol-related problems, including drunk driving.
|
23969552 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
It has been well documented that variant alleles of both ADH1B*2 of alcohol dehydrogenase (ADH) and ALDH2*2 of aldehyde dehydrogenase (ALDH) protect against the development of alcoholism in East Asians.
|
25365528 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
CTD_human |
To date, the only genes that have been consistently replicated across racial and ethnic groups to influence alcoholism vulnerability are polymorphisms in the alcohol-metabolizing enzymes, i.e. cytosolic alcohol dehydrogenase 1B (ADH1B) and mitochondrial aldehyde dehydrogenase 2 (ALDH2).
|
17590986 |
2007 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
We tested the most significant ADH1B single nucleotide polymorphisms for alcohol dependence from a genomewide association study with this sample, ADH1B-rs1229984 (Arg48His) and ADH1B-rs2066702 (Arg370Cys), in EA and AA subsamples, respectively.
|
25410943 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
CTD_human |
In this study the functional effects of the two SNPs (rs1159918 and rs1229982) in the proximal promoter region of ADH1B that were associated with alcoholism were explored.
|
21168396 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
CTD_human |
The hypothesized mechanism underlying the associations of the ADH1B and ALDH2 polymorphisms with alcohol dependence is that the isoenzymes encoded by these alleles lead to an accumulation of acetaldehyde during alcohol metabolism.
|
16404797 |
2005 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
We developed a time- and cost-effective multiplex allele-specific polymerase chain reaction (AS-PCR) method based on the two-step PCR thermal cycles for genotyping single-nucleotide polymorphisms in three alcoholism-related genes: alcohol dehydrogenase 1B, aldehyde dehydrogenase 2 and μ-opioid receptor.
|
25382047 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
The presence of the less-active form of alcohol dehydrogenase-1B encoded by ADH1B*1/*1 (vs. *2 allele) and active form of aldehyde dehydrogenase-2 (ALDH2) encoded by ALDH2*1/*1 (vs. *2 allele) increases the risk of alcoholism in East Asians.
|
23550892 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Regular male drinkers without alcohol dependence (n = 112) ages 18-25 years participated in alcohol challenge sessions consisting of placebo and two doses of alcohol (target BrAC: 0 g/dl for placebo, .04 g/dl low dose, and .08 g/dl high dose) and genotyped for variants in ADH1B*3 and ADH1C*2.
|
25208201 |
2014 |
|
Anterior Choroidal Artery Infarction
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae.
|
15534263 |
2004 |