|
Colorectal Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan.
|
16332725 |
2006 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
CTD_human |
Acetaldehyde, polymorphisms and the cardiovascular system.
|
17590986 |
2007 |
|
Alcohol Use Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
Acetaldehyde, polymorphisms and the cardiovascular system.
|
17590986 |
2007 |
|
Cerebral Infarction, Left Hemisphere
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae.
|
15534263 |
2004 |
|
Cerebral Infarction, Right Hemisphere
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae.
|
15534263 |
2004 |
|
Anterior Choroidal Artery Infarction
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae.
|
15534263 |
2004 |
|
Subcortical Infarction
|
0.300 |
Biomarker
|
disease |
CTD_human |
Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae.
|
15534263 |
2004 |
|
Posterior Choroidal Artery Infarction
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae.
|
15534263 |
2004 |
|
Nonalcoholic Steatohepatitis
|
0.310 |
Biomarker
|
disease |
CTD_human |
Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis.
|
29718361 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
0.300 |
Biomarker
|
disease |
CTD_human |
Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis.
|
29718361 |
2018 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
Alcoholic Intoxication
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Gene-environment interactions on the risk of esophageal cancer among Asian populations with the G48A polymorphism in the alcohol dehydrogenase-2 gene: a meta-analysis.
|
24446180 |
2014 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
CTD_human |
Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action.
|
16404797 |
2005 |
|
Alcohol Use Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action.
|
16404797 |
2005 |
|
Colorectal Carcinoma
|
0.390 |
Biomarker
|
disease |
CTD_human |
Genetic polymorphisms, aldehyde dehydrogenase (ALDH2) Glu487Lys and alcohol dehydrogenase 2 (ADH2) His47Arg, which have a strong impact on alcohol metabolism, are common in Japanese population but their significance for CRC carcinogenesis remains to be clarified in detail.
|
16332725 |
2006 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Given the logistic and ethical constraints that would be associated with a trial of alcohol use to prevent depression, we aimed to complete a Mendelian randomization study to determine if a genetic polymorphism associated with alcohol abuse and dependence (ADH1B rs1229984 G-->A) contributed to modulate the risk of depression in a community-derived cohort of older men.
|
24018899 |
2014 |
|
Alcoholic Intoxication
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Higher responses on the SHAS items muddle/confused and nauseated were significantly associated with the presence of at least one ADH1B*3 allele following the high dose of alcohol in Afro-T. Indo-T with at least one ADH1C*2 allele displayed significantly different Drug × Time interactions for the SHAS item effects of alcohol at the low dose and for the SHAS items clumsy, muddle/confused, effects of alcohol, floating, drunk, and total at the high dose from Indo-T with two ADH1C*1 alleles.
|
25208201 |
2014 |
|
Alcoholic Intoxication
|
0.310 |
Biomarker
|
disease |
PSYGENET |
In subgroup analyses according to smoking and alcohol drinking status, the OR of the ADH1B*1*1 genotype was increased in the heavy drinker group [8.85 (1.095-40.0)] and in the heavy smoker group [4.7 (1.54-14.29)].
|
21576033 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
CTD_human |
In this study the functional effects of the two SNPs (rs1159918 and rs1229982) in the proximal promoter region of ADH1B that were associated with alcoholism were explored.
|
21168396 |
2011 |
|
Hangover from alcohol
|
0.300 |
Biomarker
|
phenotype |
PSYGENET |
Individuals with an ADH1B*2 allele had lower rates of AUDs, consumed a lower maximum number of drinks in a 24-hr period, reported a greater level of response to alcohol, were more likely to have experienced alcohol-induced headaches following 1 or 2 drinks, and reported more severe hangovers than those lacking this allele.
|
16117582 |
2005 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
It has been well documented that variant alleles of both ADH1B*2 of alcohol dehydrogenase (ADH) and ALDH2*2 of aldehyde dehydrogenase (ALDH) protect against the development of alcoholism in East Asians.
|
25365528 |
2014 |
|
Esophageal Neoplasms
|
0.500 |
Biomarker
|
group |
CTD_human |
Multiple ADH genes are associated with upper aerodigestive cancers.
|
18500343 |
2008 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
CTD_human |
Multiple ADH genes are associated with upper aerodigestive cancers.
|
18500343 |
2008 |
|
Pharyngeal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Multiple ADH genes are associated with upper aerodigestive cancers.
|
18500343 |
2008 |
|
Malignant neoplasm of mouth
|
0.400 |
Biomarker
|
group |
CTD_human |
Multiple ADH genes are associated with upper aerodigestive cancers.
|
18500343 |
2008 |