Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease 		0.300 Biomarker disease CTD_human Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis. 29718361 2018
CUI: C0023055
Disease: Laryngeal neoplasm
Laryngeal neoplasm 		0.300 Biomarker disease CTD_human Multiple ADH genes are associated with upper aerodigestive cancers. 18500343 2008
CUI: C0026640
Disease: Mouth Neoplasms
Mouth Neoplasms 		0.300 Biomarker group CTD_human Multiple ADH genes are associated with upper aerodigestive cancers. 18500343 2008
CUI: C0393756
Disease: Hangover from alcohol
Hangover from alcohol 		0.300 Biomarker phenotype PSYGENET Individuals with an ADH1B*2 allele had lower rates of AUDs, consumed a lower maximum number of drinks in a 24-hr period, reported a greater level of response to alcohol, were more likely to have experienced alcohol-induced headaches following 1 or 2 drinks, and reported more severe hangovers than those lacking this allele. 16117582 2005
CUI: C0751010
Disease: Cerebral Infarction, Left Hemisphere
Cerebral Infarction, Left Hemisphere 		0.300 Biomarker phenotype CTD_human Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae. 15534263 2004
CUI: C0751011
Disease: Cerebral Infarction, Right Hemisphere
Cerebral Infarction, Right Hemisphere 		0.300 Biomarker phenotype CTD_human Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae. 15534263 2004
CUI: C0751012
Disease: Anterior Choroidal Artery Infarction
Anterior Choroidal Artery Infarction 		0.300 Biomarker phenotype CTD_human Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae. 15534263 2004
CUI: C0751014
Disease: Subcortical Infarction
Subcortical Infarction 		0.300 Biomarker disease CTD_human Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae. 15534263 2004
CUI: C0887799
Disease: Posterior Choroidal Artery Infarction
Posterior Choroidal Artery Infarction 		0.300 Biomarker phenotype CTD_human Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae. 15534263 2004
CUI: C3241937
Disease: Nonalcoholic Steatohepatitis
Nonalcoholic Steatohepatitis 		0.310 Biomarker disease CTD_human Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis. 29718361 2018
CUI: C0001969
Disease: Alcoholic Intoxication
Alcoholic Intoxication 		0.310 Biomarker disease PSYGENET Higher responses on the SHAS items muddle/confused and nauseated were significantly associated with the presence of at least one ADH1B*3 allele following the high dose of alcohol in Afro-T. Indo-T with at least one ADH1C*2 allele displayed significantly different Drug × Time interactions for the SHAS item effects of alcohol at the low dose and for the SHAS items clumsy, muddle/confused, effects of alcohol, floating, drunk, and total at the high dose from Indo-T with two ADH1C*1 alleles. 25208201 2014
CUI: C0001969
Disease: Alcoholic Intoxication
Alcoholic Intoxication 		0.310 Biomarker disease PSYGENET Gene-environment interactions on the risk of esophageal cancer among Asian populations with the G48A polymorphism in the alcohol dehydrogenase-2 gene: a meta-analysis. 24446180 2014
CUI: C0001969
Disease: Alcoholic Intoxication
Alcoholic Intoxication 		0.310 Biomarker disease PSYGENET The longer-than-expected EtOH lingering in the blood of the ADH1B*1/*1 alcoholics may exacerbate alcohol-related problems, including drunk driving. 23969552 2014
CUI: C0001969
Disease: Alcoholic Intoxication
Alcoholic Intoxication 		0.310 Biomarker disease PSYGENET This suggests that drunk drivers with augmented MCV modulated by the alcohol metabolic ADH1B*1/*1 genotype may be at higher risk of driving incapability and of alcohol-related cancer. 21917409 2012
CUI: C0001969
Disease: Alcoholic Intoxication
Alcoholic Intoxication 		0.310 Biomarker disease PSYGENET In subgroup analyses according to smoking and alcohol drinking status, the OR of the ADH1B*1*1 genotype was increased in the heavy drinker group [8.85 (1.095-40.0)] and in the heavy smoker group [4.7 (1.54-14.29)]. 21576033 2011
CUI: C0028754
Disease: Obesity
Obesity 		0.310 Biomarker disease CTD_human Orchestrated downregulation of genes involved in oxidative metabolic pathways in obese vs. lean high-fat young male consumers. 20882379 2011
CUI: C0153405
Disease: Malignant neoplasm of pharynx
Malignant neoplasm of pharynx 		0.310 Biomarker disease CTD_human Multiple ADH genes are associated with upper aerodigestive cancers. 18500343 2008
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.310 Biomarker disease CTD_human Multiple regression analyses confirmed that the risk of lacunae and cerebral infarction was increased by the ADH2*1 allele. 15534263 2004
CUI: C0349464
Disease: Wernicke-Korsakoff Syndrome
Wernicke-Korsakoff Syndrome 		0.310 Biomarker disease PSYGENET These findings suggest that the ADH2*1/2*1 genotype is a risk factor for the development of WKS in alcoholic patients. 10776671 2000
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders 		0.320 Biomarker group PSYGENET Those with ALDH2 *1/*1 and ADH1B *1/*1 were also likely to be at an increased risk of any mental disorder except ARD, as well as disorders without comorbid ARD. 25411394 2015
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.320 Biomarker group CTD_human A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan. 16332725 2006
CUI: C0007107
Disease: Malignant neoplasm of larynx
Malignant neoplasm of larynx 		0.330 Biomarker disease CTD_human Multiple ADH genes are associated with upper aerodigestive cancers. 18500343 2008
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.390 Biomarker disease CTD_human Genetic polymorphisms, aldehyde dehydrogenase (ALDH2) Glu487Lys and alcohol dehydrogenase 2 (ADH2) His47Arg, which have a strong impact on alcohol metabolism, are common in Japanese population but their significance for CRC carcinogenesis remains to be clarified in detail. 16332725 2006
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.400 Biomarker disease CTD_human We confirmed the known association of the ALDH2 locus on 12q24 to ESCC, and a joint analysis showed that drinkers with both of the ADH1B and ALDH2 risk alleles had a fourfold increased risk for ESCC compared to drinkers without these risk alleles. 22960999 2012
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease CTD_human Variation in the ADH1B proximal promoter affects expression. 21168396 2011