Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 Biomarker disease CTD_human To date, the only genes that have been consistently replicated across racial and ethnic groups to influence alcoholism vulnerability are polymorphisms in the alcohol-metabolizing enzymes, i.e. cytosolic alcohol dehydrogenase 1B (ADH1B) and mitochondrial aldehyde dehydrogenase 2 (ALDH2). 17590986 2007
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 Biomarker disease CTD_human In this study the functional effects of the two SNPs (rs1159918 and rs1229982) in the proximal promoter region of ADH1B that were associated with alcoholism were explored. 21168396 2011
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 Biomarker disease CTD_human The hypothesized mechanism underlying the associations of the ADH1B and ALDH2 polymorphisms with alcohol dependence is that the isoenzymes encoded by these alleles lead to an accumulation of acetaldehyde during alcohol metabolism. 16404797 2005
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.600 Biomarker disease CTD_human Acetaldehyde, polymorphisms and the cardiovascular system. 17590986 2007
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.600 Biomarker disease CTD_human Variation in the ADH1B proximal promoter affects expression. 21168396 2011
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.600 Biomarker disease CTD_human Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action. 16404797 2005
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.500 Biomarker group CTD_human Multiple ADH genes are associated with upper aerodigestive cancers. 18500343 2008
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		0.500 Biomarker disease CTD_human Multiple ADH genes are associated with upper aerodigestive cancers. 18500343 2008
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease CTD_human Acetaldehyde, polymorphisms and the cardiovascular system. 17590986 2007
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease CTD_human Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action. 16404797 2005
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease CTD_human Variation in the ADH1B proximal promoter affects expression. 21168396 2011
CUI: C0031347
Disease: Pharyngeal Neoplasms
Pharyngeal Neoplasms 		0.400 Biomarker group CTD_human Multiple ADH genes are associated with upper aerodigestive cancers. 18500343 2008
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth 		0.400 Biomarker group CTD_human Multiple ADH genes are associated with upper aerodigestive cancers. 18500343 2008
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.400 Biomarker disease CTD_human We confirmed the known association of the ALDH2 locus on 12q24 to ESCC, and a joint analysis showed that drinkers with both of the ADH1B and ALDH2 risk alleles had a fourfold increased risk for ESCC compared to drinkers without these risk alleles. 22960999 2012
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.390 Biomarker disease CTD_human Genetic polymorphisms, aldehyde dehydrogenase (ALDH2) Glu487Lys and alcohol dehydrogenase 2 (ADH2) His47Arg, which have a strong impact on alcohol metabolism, are common in Japanese population but their significance for CRC carcinogenesis remains to be clarified in detail. 16332725 2006
CUI: C0007107
Disease: Malignant neoplasm of larynx
Malignant neoplasm of larynx 		0.330 Biomarker disease CTD_human Multiple ADH genes are associated with upper aerodigestive cancers. 18500343 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.320 Biomarker group CTD_human A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan. 16332725 2006
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.310 Biomarker disease CTD_human Multiple regression analyses confirmed that the risk of lacunae and cerebral infarction was increased by the ADH2*1 allele. 15534263 2004
CUI: C0028754
Disease: Obesity
Obesity 		0.310 Biomarker disease CTD_human Orchestrated downregulation of genes involved in oxidative metabolic pathways in obese vs. lean high-fat young male consumers. 20882379 2011
CUI: C0153405
Disease: Malignant neoplasm of pharynx
Malignant neoplasm of pharynx 		0.310 Biomarker disease CTD_human Multiple ADH genes are associated with upper aerodigestive cancers. 18500343 2008
CUI: C3241937
Disease: Nonalcoholic Steatohepatitis
Nonalcoholic Steatohepatitis 		0.310 Biomarker disease CTD_human Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis. 29718361 2018
CUI: C0023055
Disease: Laryngeal neoplasm
Laryngeal neoplasm 		0.300 Biomarker disease CTD_human Multiple ADH genes are associated with upper aerodigestive cancers. 18500343 2008
CUI: C0026640
Disease: Mouth Neoplasms
Mouth Neoplasms 		0.300 Biomarker group CTD_human Multiple ADH genes are associated with upper aerodigestive cancers. 18500343 2008
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease 		0.300 Biomarker disease CTD_human Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis. 29718361 2018
CUI: C0751010
Disease: Cerebral Infarction, Left Hemisphere
Cerebral Infarction, Left Hemisphere 		0.300 Biomarker phenotype CTD_human Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae. 15534263 2004