|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
It has been well documented that variant alleles of both ADH1B*2 of alcohol dehydrogenase (ADH) and ALDH2*2 of aldehyde dehydrogenase (ALDH) protect against the development of alcoholism in East Asians.
|
25365528 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
We tested the most significant ADH1B single nucleotide polymorphisms for alcohol dependence from a genomewide association study with this sample, ADH1B-rs1229984 (Arg48His) and ADH1B-rs2066702 (Arg370Cys), in EA and AA subsamples, respectively.
|
25410943 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
We developed a time- and cost-effective multiplex allele-specific polymerase chain reaction (AS-PCR) method based on the two-step PCR thermal cycles for genotyping single-nucleotide polymorphisms in three alcoholism-related genes: alcohol dehydrogenase 1B, aldehyde dehydrogenase 2 and μ-opioid receptor.
|
25382047 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Regular male drinkers without alcohol dependence (n = 112) ages 18-25 years participated in alcohol challenge sessions consisting of placebo and two doses of alcohol (target BrAC: 0 g/dl for placebo, .04 g/dl low dose, and .08 g/dl high dose) and genotyped for variants in ADH1B*3 and ADH1C*2.
|
25208201 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
The presence of the less-active form of alcohol dehydrogenase-1B encoded by ADH1B*1/*1 (vs. *2 allele) and active form of aldehyde dehydrogenase-2 (ALDH2) encoded by ALDH2*1/*1 (vs. *2 allele) increases the risk of alcoholism in East Asians.
|
23550892 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
CTD_human |
In this study the functional effects of the two SNPs (rs1159918 and rs1229982) in the proximal promoter region of ADH1B that were associated with alcoholism were explored.
|
21168396 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
CTD_human |
To date, the only genes that have been consistently replicated across racial and ethnic groups to influence alcoholism vulnerability are polymorphisms in the alcohol-metabolizing enzymes, i.e. cytosolic alcohol dehydrogenase 1B (ADH1B) and mitochondrial aldehyde dehydrogenase 2 (ALDH2).
|
17590986 |
2007 |
|
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
CTD_human |
The hypothesized mechanism underlying the associations of the ADH1B and ALDH2 polymorphisms with alcohol dependence is that the isoenzymes encoded by these alleles lead to an accumulation of acetaldehyde during alcohol metabolism.
|
16404797 |
2005 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
We genotyped the rs1229984 G→A variant of the alcohol dehydrogenase 1B (ADH1B) gene, which is associated with lower prevalence of alcohol abuse and dependence.
|
24553426 |
2014 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Given the logistic and ethical constraints that would be associated with a trial of alcohol use to prevent depression, we aimed to complete a Mendelian randomization study to determine if a genetic polymorphism associated with alcohol abuse and dependence (ADH1B rs1229984 G-->A) contributed to modulate the risk of depression in a community-derived cohort of older men.
|
24018899 |
2014 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The ADH1B gene has consistently been implicated in problem drinking, but rarely incorporated into gene by environment investigations of alcohol phenotypes.
|
25410943 |
2014 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The ADH1B genotype was associated with the frequency and volume of drinking but its associations with binge drinking and problem drinking were less consistent.
|
22150722 |
2012 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
CTD_human |
Variation in the ADH1B proximal promoter affects expression.
|
21168396 |
2011 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
CTD_human |
Acetaldehyde, polymorphisms and the cardiovascular system.
|
17590986 |
2007 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
CTD_human |
Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action.
|
16404797 |
2005 |
|
Esophageal Neoplasms
|
0.500 |
Biomarker
|
group |
CTD_human |
Multiple ADH genes are associated with upper aerodigestive cancers.
|
18500343 |
2008 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
CTD_human |
Multiple ADH genes are associated with upper aerodigestive cancers.
|
18500343 |
2008 |
|
Squamous cell carcinoma of esophagus
|
0.400 |
Biomarker
|
disease |
CTD_human |
We confirmed the known association of the ALDH2 locus on 12q24 to ESCC, and a joint analysis showed that drinkers with both of the ADH1B and ALDH2 risk alleles had a fourfold increased risk for ESCC compared to drinkers without these risk alleles.
|
22960999 |
2012 |
|
Alcohol Use Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
Variation in the ADH1B proximal promoter affects expression.
|
21168396 |
2011 |
|
Pharyngeal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Multiple ADH genes are associated with upper aerodigestive cancers.
|
18500343 |
2008 |
|
Malignant neoplasm of mouth
|
0.400 |
Biomarker
|
group |
CTD_human |
Multiple ADH genes are associated with upper aerodigestive cancers.
|
18500343 |
2008 |
|
Alcohol Use Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
Acetaldehyde, polymorphisms and the cardiovascular system.
|
17590986 |
2007 |
|
Alcohol Use Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action.
|
16404797 |
2005 |
|
Colorectal Carcinoma
|
0.390 |
Biomarker
|
disease |
CTD_human |
Genetic polymorphisms, aldehyde dehydrogenase (ALDH2) Glu487Lys and alcohol dehydrogenase 2 (ADH2) His47Arg, which have a strong impact on alcohol metabolism, are common in Japanese population but their significance for CRC carcinogenesis remains to be clarified in detail.
|
16332725 |
2006 |