Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
PPP6C O00743 protein phosphatase 6 catalytic subunit 0.86 0.729 0.231 2
DDB2 Q92466 damage specific DNA binding protein 2 Nucleic acid binding 7.4E-06 0.576 0.654 4
TRRAP Q9Y4A5 transformation/transcription domain associated protein 1.00 0.572 0.692 2
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 14
STAG2 Q8N3U4 stromal antigen 2 Nucleic acid binding 1.00 0.568 0.731 12
ERCC5 P28715 ERCC excision repair 5, endonuclease 2.7E-13 0.499 0.731 4
GNA11 P29992 G protein subunit alpha 11 Enzyme modulator 0.89 0.563 0.731 3
MAP2K2 P36507 mitogen-activated protein kinase kinase 2 Kinase 0.97 0.534 0.731 3
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 17
STK11 Q15831 serine/threonine kinase 11 Kinase 0.99 0.435 0.808 17
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 16
CDK4 P11802 cyclin dependent kinase 4 Kinase 6.3E-02 0.412 0.808 5
PDGFRA P16234 platelet derived growth factor receptor alpha Kinase 1.00 0.415 0.808 5
XPC Q01831 XPC complex subunit, DNA damage recognition and repair factor Nucleic acid binding 3.7E-11 0.504 0.808 4
GNAQ P50148 G protein subunit alpha q Enzyme modulator 0.98 0.516 0.808 3
MITF O75030 melanocyte inducing transcription factor 0.98 0.499 0.808 2
PAK1 Q13153 p21 (RAC1) activated kinase 1 Kinase 1.3E-03 0.494 0.808 2
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
ALK Q9UM73 ALK receptor tyrosine kinase Kinase 3.2E-06 0.396 0.846 11
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846 10
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 Kinase 0.90 0.439 0.846 10
CUX1 P39880 Q13948 cut like homeobox 1 Transcription factor 1.00 0.465 0.846 9
ERCC4 Q92889 ERCC excision repair 4, endonuclease catalytic subunit Enzyme 1.4E-12 0.468 0.846 8
ERBB4 Q15303 erb-b2 receptor tyrosine kinase 4 Kinase 1.00 0.455 0.846 6