Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 20
ALK Q9UM73 ALK receptor tyrosine kinase Kinase 3.2E-06 0.396 0.846 11
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 14
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 3
CDK4 P11802 cyclin dependent kinase 4 Kinase 6.3E-02 0.412 0.808 5
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 8
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 23
CUX1 P39880 Q13948 cut like homeobox 1 Transcription factor 1.00 0.465 0.846 9
DDB2 Q92466 damage specific DNA binding protein 2 Nucleic acid binding 7.4E-06 0.576 0.654 4
ERBB4 Q15303 erb-b2 receptor tyrosine kinase 4 Kinase 1.00 0.455 0.846 6
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846 10
ERCC3 P19447 ERCC excision repair 3, TFIIH core complex helicase subunit Enzyme 3.4E-11 0.504 0.846 4
ERCC4 Q92889 ERCC excision repair 4, endonuclease catalytic subunit Enzyme 1.4E-12 0.468 0.846 8
ERCC5 P28715 ERCC excision repair 5, endonuclease 2.7E-13 0.499 0.731 4
GNA11 P29992 G protein subunit alpha 11 Enzyme modulator 0.89 0.563 0.731 3
GNAQ P50148 G protein subunit alpha q Enzyme modulator 0.98 0.516 0.808 3
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 29
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 16
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 Kinase 0.90 0.439 0.846 10
MAP2K2 P36507 mitogen-activated protein kinase kinase 2 Kinase 0.97 0.534 0.731 3
MITF O75030 melanocyte inducing transcription factor 0.98 0.499 0.808 2
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885 8
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 17