Source: CGI

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 23
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 8
ERCC5 P28715 ERCC excision repair 5, endonuclease 2.7E-13 0.499 0.731 4
MITF O75030 melanocyte inducing transcription factor 0.98 0.499 0.808 2
PPP6C O00743 protein phosphatase 6 catalytic subunit 0.86 0.729 0.231 2
TRRAP Q9Y4A5 transformation/transcription domain associated protein 1.00 0.572 0.692 2
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 27
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 14
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846 10
ERCC4 Q92889 ERCC excision repair 4, endonuclease catalytic subunit Enzyme 1.4E-12 0.468 0.846 8
ERCC3 P19447 ERCC excision repair 3, TFIIH core complex helicase subunit Enzyme 3.4E-11 0.504 0.846 4
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 29
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 17
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885 8
GNA11 P29992 G protein subunit alpha 11 Enzyme modulator 0.89 0.563 0.731 3
GNAQ P50148 G protein subunit alpha q Enzyme modulator 0.98 0.516 0.808 3
RAC1 P63000 Rac family small GTPase 1 Enzyme modulator 0.76 0.429 0.962 3
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 3
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 45
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 33
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 20
STK11 Q15831 serine/threonine kinase 11 Kinase 0.99 0.435 0.808 17
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 16
ALK Q9UM73 ALK receptor tyrosine kinase Kinase 3.2E-06 0.396 0.846 11