Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 59
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 47
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 36
TP73 O15350 tumor protein p73 Transcription factor 1.00 0.449 0.808 27
ETS1 P14921 ETS proto-oncogene 1, transcription factor Transcription factor 0.78 0.444 0.731 15
ETV6 P41212 ETS variant transcription factor 6 Transcription factor 0.97 0.477 0.731 13
YY1 P25490 YY1 transcription factor Transcription factor 0.99 0.481 0.808 6
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923 53
F3 P13726 coagulation factor III, tissue factor Receptor 1.9E-02 0.415 0.846 41
RB1 P06400 RB transcriptional corepressor 1 Nucleic acid binding 1.00 0.444 0.885 39
PGR P06401 progesterone receptor Nuclear receptor 5.1E-02 0.426 0.885 21
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 32
SSTR2 P30874 somatostatin receptor 2 G-protein coupled receptor 0.44 0.539 0.731 11
GNRHR P30968 gonadotropin releasing hormone receptor G-protein coupled receptor 6.8E-02 0.540 0.654 5
MSLN Q13421 mesothelin Extracellular structure 5.9E-25 0.525 0.692 10
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 65
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885 64
BIRC5 O15392 baculoviral IAP repeat containing 5 Enzyme modulator 5.6E-02 0.495 0.731 50
RASSF1 Q9NS23 Ras association domain family member 1 Enzyme modulator 4.9E-06 0.420 0.808 28
CAV1 Q03135 caveolin 1 Enzyme modulator 8.3E-03 0.388 0.885 26
BCR P11274 BCR activator of RhoGEF and GTPase Enzyme modulator 0.99 0.431 0.885 12