Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke. 23028794

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Chemical and Drug Induced Liver Injury
0.500 Biomarker RGD Potential protective effect of honey against paracetamol-induced hepatotoxicity. 23102243

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.300 Biomarker RGD A study on immunopathogenetic mechanisms of atherosclerotic process caused by chronic infection of Chlamydia pneumoniae in rats (Ratus novergicus). 17132885

2007

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0009952
Disease: Febrile Convulsions
Febrile Convulsions
0.300 Biomarker RGD When animals were treated with IL-1beta ICV, a dose-dependant increase was noted in the proportion of animals that experienced FCs, whereas increasing doses of IL-1ra, given to separate groups of animals, were anticonvulsant. 16393156

2005

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 Biomarker RGD (Pro)renin receptor contributes to diabetic nephropathy by enhancing renal inflammation. 19769609

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.300 Biomarker RGD Higher levels of proinflammatory cytokines(IL-1β, IL-6, TNF-α) were found both in the brain tissue and the serum in the epilepsy rats of each group. 28303499

2017

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.300 Biomarker RGD Hyperglycemia in streptozotocin-induced diabetes leads to persistent inflammation and tissue damage following uveitis due to reduced levels of ciliary body heme oxygenase-1. 17047293

2006

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.300 Biomarker RGD A quantitative study of lung dysfunction following haemorrhagic shock in rats. 20041965

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.300 Biomarker RGD Isoflurane preconditioning ameliorates endotoxin-induced acute lung injury and mortality in rats. 19843795

2009

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.300 Biomarker RGD Ghrelin attenuates acute pancreatitis-induced lung injury and inhibits substance P expression. 19926967

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker RGD The effect of chronic candesartan therapy on the metabolic profile and renal tissue cytokine levels in the obese Zucker rat. 20490358

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.300 Biomarker RGD Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson's disease. 23159314

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0031099
Disease: Periodontitis
Periodontitis
0.300 Biomarker RGD Lipopolysaccharide induces a stromal-epithelial signalling axis in a rat model of chronic periodontitis. 23167849

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.300 Biomarker RGD Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development. 14678765

2003

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.300 Biomarker RGD Thereafter, spontaneous convulsions (SCs), mossy fiber sprouting (MFS), neuronal loss, activation of microglia and astrocytes, expressions of interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNFα) were evaluated in the SE rats. 22960129

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker RGD A model of myocardial inflammation and dysfunction in burn complicated by sepsis. 17529909

2007

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.300 Biomarker RGD Isoflurane induces learning impairment that is mediated by interleukin 1β in rodents. 23251531

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0376618
Disease: Endotoxemia
Endotoxemia
0.300 Biomarker RGD Endotoxin-induced acute lung injury is enhanced in rats with spontaneous hypertension. 17201737

2007

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.280 Biomarker RGD Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-κB pathway. 22728154

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.280 Biomarker RGD Curcumin and enalapril ameliorate renal failure by antagonizing inflammation in 5/6 nephrectomized rats: role of phospholipase and cyclooxygenase. 22031851

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.280 Biomarker RGD CRF rats showed increased plasma IL-1 alpha, IL1-beta, IL-6, TNF-alpha, and sICAM-1 levels and decreased anti-inflammatory cytokines IL-4 and 10 levels, hypertension, and dyslipidemia. 20199183

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.280 Biomarker RGD Curcumin and enalapril ameliorate renal failure by antagonizing inflammation in 5/6 nephrectomized rats: role of phospholipase and cyclooxygenase. 22031851

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.280 Biomarker RGD Multiple antioxidants and L-arginine modulate inflammation and dyslipidemia in chronic renal failure rats. 20199183

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0042164
Disease: Uveitis
Uveitis
0.270 Biomarker RGD Interleukin-1 alpha, interleukin-1 beta, and tumor necrosis factor gene expression in endotoxin-induced uveitis. 8125721

1994

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0014038
Disease: Encephalitis
Encephalitis
0.260 Biomarker RGD The signal transduction pathways involved in hepatic cytochrome P450 regulation in the rat during a lipopolysaccharide-induced model of central nervous system inflammation. 16006567

2005