Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8878
Gene Symbol: SQSTM1
SQSTM1 		0.310 GeneticVariation disease BEFREE SQSTM1 mutations in French patients with frontotemporal dementia or frontotemporal dementia with amyotrophic lateral sclerosis. 24042580 2013
Entrez Id: 203228
Gene Symbol: C9orf72
C9orf72 		0.310 GeneticVariation disease BEFREE The study examined whether there are clinical differences between FTD-ALS patients with and without expansions in C9orf72. 23421625 2013
Entrez Id: 8878
Gene Symbol: SQSTM1
SQSTM1 		0.310 Biomarker disease CTD_human Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism. 19765191 2009
Entrez Id: 203228
Gene Symbol: C9orf72
C9orf72 		0.310 Biomarker disease CTD_human Genetic variation associated with the occurrence and progression of neurological disorders. 27713094 2017
Entrez Id: 2936
Gene Symbol: GSR
GSR 		0.300 Biomarker disease CTD_human Alterations in anti-oxidative defence enzymes in erythrocytes from sporadic amyotrophic lateral sclerosis (SALS) and familial ALS patients. 16681429 2006
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1/DREAM/PDYN pathway. 30503815 2019
Entrez Id: 755
Gene Symbol: CFAP410
CFAP410 		0.300 Biomarker disease CTD_human Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. 27455348 2016
Entrez Id: 6529
Gene Symbol: SLC6A1
SLC6A1 		0.300 Biomarker disease CTD_human In vitro activation of GAT1 transporters expressed in spinal cord gliosomes stimulates glutamate release that is abnormally elevated in the SOD1/G93A(+) mouse model of amyotrophic lateral sclerosis. 20132478 2010
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP 		0.300 Biomarker disease CTD_human Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. 23104007 2012
Entrez Id: 10280
Gene Symbol: SIGMAR1
SIGMAR1 		0.300 Biomarker disease CTD_human Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G⁹³A ALS mice: overlapping effects or limited therapeutic opportunity? 24885036 2014
Entrez Id: 25978
Gene Symbol: CHMP2B
CHMP2B 		0.300 Biomarker disease CTD_human ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B). 16807408 2006
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G⁹³A ALS mice: overlapping effects or limited therapeutic opportunity? 24885036 2014
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells. 18233996 2008
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neurons. 20132483 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.300 Biomarker disease CTD_human Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. 11220737 2001
Entrez Id: 23256
Gene Symbol: SCFD1
SCFD1 		0.300 Biomarker disease CTD_human Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. 27455348 2016
Entrez Id: 6506
Gene Symbol: SLC1A2
SLC1A2 		0.300 Biomarker disease CTD_human Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels. 11723166 2001
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Disrupted zinc-binding sites in structures of pathogenic SOD1 variants D124V and H80R. 20515040 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.300 Biomarker disease CTD_human Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. 15816863 2005
Entrez Id: 5444
Gene Symbol: PON1
PON1 		0.300 Biomarker disease CTD_human Organophosphate neurotoxicity to the voluntary motor system on the trail of environment-caused amyotrophic lateral sclerosis: the known, the misknown, and the unknown. 28070599 2017
Entrez Id: 23025
Gene Symbol: UNC13A
UNC13A 		0.300 Biomarker disease CTD_human Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. 19734901 2009
Entrez Id: 6311
Gene Symbol: ATXN2
ATXN2 		0.300 Biomarker disease CTD_human Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis. 27377857 2017
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1 		0.300 Biomarker disease CTD_human Activity and expression of glutathione S-transferase pi in patients with amyotrophic lateral sclerosis. 16109392 2006
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP 		0.300 Biomarker disease CTD_human TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. 18372902 2008
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human Motor neuron dysfunction in a mouse model of ALS: gender-dependent effect of P2X7 antagonism. 23583883 2013