Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6311
Gene Symbol: ATXN2
ATXN2 		0.300 Biomarker disease CTD_human Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis. 27377857 2017
Entrez Id: 203228
Gene Symbol: C9orf72
C9orf72 		0.310 Biomarker disease CTD_human Genetic variation associated with the occurrence and progression of neurological disorders. 27713094 2017
Entrez Id: 203228
Gene Symbol: C9orf72
C9orf72 		0.310 GeneticVariation disease BEFREE The study examined whether there are clinical differences between FTD-ALS patients with and without expansions in C9orf72. 23421625 2013
Entrez Id: 57172
Gene Symbol: CAMK1G
CAMK1G 		0.300 Biomarker disease CTD_human Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis. 23624525 2013
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG 		0.300 Therapeutic disease CTD_human From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis. 20348957 2010
Entrez Id: 755
Gene Symbol: CFAP410
CFAP410 		0.300 Biomarker disease CTD_human Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. 27455348 2016
Entrez Id: 400916
Gene Symbol: CHCHD10
CHCHD10 		0.010 Biomarker disease BEFREE Screening of CHCHD10 in a French cohort confirms the involvement of this gene in frontotemporal dementia with amyotrophic lateral sclerosis patients. 25155093 2014
Entrez Id: 25978
Gene Symbol: CHMP2B
CHMP2B 		0.300 Biomarker disease CTD_human ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B). 16807408 2006
Entrez Id: 51163
Gene Symbol: DBR1
DBR1 		0.300 Therapeutic disease CTD_human Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. 23104007 2012
Entrez Id: 1804
Gene Symbol: DPP6
DPP6 		0.300 Biomarker disease CTD_human Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. 18084291 2008
Entrez Id: 2521
Gene Symbol: FUS
FUS 		0.300 Biomarker disease CTD_human ALS mutations of FUS suppress protein translation and disrupt the regulation of nonsense-mediated decay. 30455313 2018
Entrez Id: 2670
Gene Symbol: GFAP
GFAP 		0.300 Biomarker disease CTD_human Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels. 11723166 2001
Entrez Id: 2936
Gene Symbol: GSR
GSR 		0.300 Biomarker disease CTD_human Alterations in anti-oxidative defence enzymes in erythrocytes from sporadic amyotrophic lateral sclerosis (SALS) and familial ALS patients. 16681429 2006
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1 		0.300 Biomarker disease CTD_human Activity and expression of glutathione S-transferase pi in patients with amyotrophic lateral sclerosis. 16109392 2006
Entrez Id: 4336
Gene Symbol: MOBP
MOBP 		0.300 Biomarker disease CTD_human Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. 27455348 2016
Entrez Id: 4750
Gene Symbol: NEK1
NEK1 		0.300 Biomarker disease CTD_human NEK1 mutations in familial amyotrophic lateral sclerosis. 26945885 2016
Entrez Id: 4750
Gene Symbol: NEK1
NEK1 		0.300 Biomarker disease CTD_human NEK1 variants confer susceptibility to amyotrophic lateral sclerosis. 27455347 2016
Entrez Id: 10133
Gene Symbol: OPTN
OPTN 		0.300 Biomarker disease CTD_human Optineurin associates with the podocyte Golgi complex to maintain its structure. 25096716 2014
Entrez Id: 10133
Gene Symbol: OPTN
OPTN 		0.300 Biomarker disease CTD_human Processing of optineurin in neuronal cells. 21059646 2011
Entrez Id: 5321
Gene Symbol: PLA2G4A
PLA2G4A 		0.300 Biomarker disease CTD_human Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. 15816863 2005
Entrez Id: 5444
Gene Symbol: PON1
PON1 		0.300 Biomarker disease CTD_human Organophosphate neurotoxicity to the voluntary motor system on the trail of environment-caused amyotrophic lateral sclerosis: the known, the misknown, and the unknown. 28070599 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.300 Biomarker disease CTD_human Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. 11220737 2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.300 Biomarker disease CTD_human Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. 15816863 2005
Entrez Id: 23256
Gene Symbol: SCFD1
SCFD1 		0.300 Biomarker disease CTD_human Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. 27455348 2016
Entrez Id: 10280
Gene Symbol: SIGMAR1
SIGMAR1 		0.300 Biomarker disease CTD_human Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G⁹³A ALS mice: overlapping effects or limited therapeutic opportunity? 24885036 2014