|
rs4672619
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we have identified a novel SNP, rs4672619, that shows interactive effects with depression on asthma symptom severity in childhood and elderly asthmatics in opposite directions.
|
29973587 |
2018 |
|
rs581724
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, SNP rs581724 was significantly associated with allergic conjunctivitis in a recessive way (p=0.007; OR=2.3 (1.3-4.4)) within the asthmatic population.
|
29667338 |
2018 |
|
rs591118
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This finding for rs591118 was validated successfully in both the paediatric asthma (OR 3·86, 95% CI 1·19-12·50; p=0·02) and adult COPD (2·41, 1·10-5·28; p=0·03) cohorts.
|
29551627 |
2018 |
|
rs60389358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic analysis of ARG1 SNPs revealed that rs2781666 G/T genotype, T allele and C-T haplotype (rs60389358 and rs2781666) were associated with susceptibility to asthma.
|
30381539 |
2018 |
|
rs7044343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No association was found between rs7044343 variant and asthma.
|
28985997 |
2018 |
|
rs721917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Met11Thr variation strongly affected serum SP-D levels and the degree of multimerization, but was not associated with COPD and asthma in the study.
|
28960651 |
2018 |
|
rs738409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe associations that may predict ADEs, e.g., acne, high cholesterol, gout, and gallstones with rs738409 (p.I148M) in PNPLA3 and asthma with rs1990760 (p.T946A) in IFIH1.
|
30327483 |
2018 |
|
rs762534
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the other hand, the minor A alleles for rs762534 and rs1800925 were not significantly associated with asthma risk.
|
29211635 |
2018 |
|
rs10056340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Inclusions of age, body mass index, and atopy in multivariate models revealed significant associations between rs10056340 (odds ratio, 2.020; 95% confidence interval, 1.283-3.180; P = .002) and all 5 17q21 SNPs and asthma in this population.
|
28668238 |
2017 |
|
rs1031509
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, having TG + GG genotypes on rs1031509 near STAT4 was associated with 5-times (95% CI, 3.03-8.55) greater odds of asthma diagnosis at the highest B[a]P range, compared to the odds at the reference range.
|
28807506 |
2017 |
|
rs1039559
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For those with childhood farm exposure, carriers of the TLR6-rs1039559 T-allele (p-interaction = 0.009) and TLR6-rs5743810 C-allele (p-interaction = 0.02) were associated with lower risk of early-onset asthma.
|
28262750 |
2017 |
|
rs10494132
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the rs10494132 polymorphism of CHIA might be a risk factor for asthma.
|
29233108 |
2017 |
|
rs10865710
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant associations were found between rs10766197 of CYP2R1, rs7041 and rs4588 of CG, rs4646536 of CYP27B1, rs2228570, rs7975232, and rs1544410 of VDR, as well as rs1805192 and rs10865710 of PPAR and susceptibility to and prognosis of childhood bronchial asthma, providing novel targets for treating the disorder.
|
28590769 |
2017 |
|
rs11225138
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The distribution of genotypes of rs11225138 and certain haplotypes of the YAP1 gene showed significant differences between different asthma severity statuses.
|
28293931 |
2017 |
|
rs12007907
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the rs12007907 variant in IL1RAPL gene was negatively associated with asthma and IL-13 production in our study and a sex-specific association was observed in one of the validation samples.
|
28120837 |
2017 |
|
rs12551256
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of IL33 SNP rs12551256 was negatively associated with asthma (OR 0.71, 95% CI: 0.53-0.94, P = 0.017).
|
28266165 |
2017 |
|
rs13217795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein we present the first report of the association between rs</span>13217795 and allergic rhinitis, and the first independent verification of the association between rs1321</span>7795 and asthma.
|
29141605 |
2017 |
|
rs1368408
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CONCLUSIONS These results suggest that the promoter SNPs (rs6882292 and rs1368408) of SCGB3A2 gene may contribute to susceptibility to asthma in a Korean population.
|
28422086 |
2017 |
|
rs1384001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In ALSPAC, there was strong evidence for association between six SNPs and asthma: rs959974 and rs1384001 (per-allele odds ratio for both: 1.30 (95% CI: 1.15-1.47), p = 0.00001), rs7010969 (OR 1.28 (1.13-1.46), p = 0.00004), rs3735945 (OR 1.30 (1.09-1.55), p = 0.003), rs920829 (OR 1.30 (1.09-1.54), p = 0.004) and rs4738202 (OR 1.22 (1.07-1.39), p = 0.004).
|
27779810 |
2017 |
|
rs16969968
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the causal effect of smoking on hay fever and asthma by using the smoking-associated single nucleotide polymorphism (SNP) rs16969968/rs1051730.
|
28533558 |
2017 |
|
rs1883832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).
|
29254239 |
2017 |
|
rs2070673
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also CYP2E1 AT + TT genotypes (rs2070673) was associated with 5-times (95% CI, 3.1-8.8) greater odds of asthma diagnosis at the highest B[a]P exposure.
|
28807506 |
2017 |
|
rs2227306
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of IL8-251 A/T (rs4073) and + 781C/T (rs2227306) polymorphisms was significantly associated with an increased risk of asthma (P = 0.002, P = 0.036, respectively).
|
28993876 |
2017 |
|
rs2381413
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of note, multiple SNPs in LD with rs2381413 located upstream of IL33 were significantly associated with asthma.
|
27177148 |
2017 |
|
rs3001978
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the AD patients without FLG mutations, the CC genotype of RPTN rs3001978 was associated with AD (OR 0.39, p = 0.037), early age at onset (p = 0.033), pruritus (p = 0.021), severity of AD (p = 0.045), and concomitant asthma (p = 0.041).
|
28219068 |
2017 |