|
rs25487
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the SNP locus rs25487 of XRCC1 could be a marker for genetic susceptibility to idiopathic azoospermia and the A allele might be a risk gene of idiopathic azoospermia in the northern Chinese Han population.
|
22868082 |
2012 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis supports that the MTHFR A1298C polymorphism is capable of causing male infertility susceptibility, especially azoospermia.
|
22175540 |
2012 |
|
rs1059060
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs1248142939
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs140756663
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two potentially disease-causing variants were detected in the infertile cohort: one man with azoospermia was found to be heterozygous for the novel TSPYL1 variant c.419C>G (p.Ser140Cys), and the rare substitution c.1098C>A (p.Phe366Leu) was identified in a man with OAT syndrome in the heterozygous state.
|
22137496 |
2012 |
|
rs17420802
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs188541504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results indicated that the polymorphism -9C>T and 368A>G in H2BFWT gene are associated with male infertility with idiopathic azoospermia or oligozoospermia, suggesting that H2BFWT gene might be contribute to susceptibility to spermatogenesis impairment in Chinese population.
|
22509975 |
2012 |
|
rs2070565
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results indicated that SNP rs2070565, as well as haplotypes AAA and GAA, may be associated with male infertility and suggest that DNMT3L may contribute to azoospermia susceptibility in humans.
|
22116073 |
2012 |
|
rs370116569
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two potentially disease-causing variants were detected in the infertile cohort: one man with azoospermia was found to be heterozygous for the novel TSPYL1 variant c.419C>G (p.Ser140Cys), and the rare substitution c.1098C>A (p.Phe366Leu) was identified in a man with OAT syndrome in the heterozygous state.
|
22137496 |
2012 |
|
rs4647269
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs553509
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results indicated that the polymorphism -9C>T and 368A>G in H2BFWT gene are associated with male infertility with idiopathic azoospermia or oligozoospermia, suggesting that H2BFWT gene might be contribute to susceptibility to spermatogenesis impairment in Chinese population.
|
22509975 |
2012 |
|
rs587781908
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs763468927
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs786203623
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs864622096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs1799983
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, the polymorphic distributions of three common polymorphism loci including T-786C, 4A4B and G894T in eNOS gene were investigated in 355 Chinese infertile patients with azoospermia or oligozoospermia and 246 healthy fertile men and a meta-analysis was carried in order to explore the possible relationship between the three loci of eNOS gene and male infertility with spermatogenesis impairment.
|
23756085 |
2013 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Pooled estimate on c.1298A>C data from all published studies including our data showed no association of this polymorphism with male infertility (Odds ratio = 1.035, P = 0.56), azoospermia (Odds ratio = 0.97, P = 0.74), or oligoasthenoteratozoospermia (Odds ratio = 0.92, p = 0.29).
|
23874907 |
2013 |
|
rs10269148
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genetic variant rs10269148 of STRA8 gene showed higher risk of spermatogenic impairment in the groups of abnormospermia (including azoospermia subgroup and oligozoospermia subgroup) and azoospermia than the controls with odds ratios and 95% confidence intervals of 2.52 (1.29-4.94) and 2.92 (1.41-6.06), respectively (P = 0.006, 0.002 respective).
|
23320086 |
2013 |
|
rs4474514
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore the possible association of KIT and KITLG genes with male infertility having spermatogenesis impairment, polymorphism distributions of SNP rs3819392 in KIT gene as well as rs995030 and rs4474514 in KITLG gene were investigated in 372 patients with idiopathic azoospermia or oligospermia and 205 fertile controls.
|
24083421 |
2013 |
|
rs995030
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore the possible association of KIT and KITLG genes with male infertility having spermatogenesis impairment, polymorphism distributions of SNP rs3819392 in KIT gene as well as rs995030 and rs4474514 in KITLG gene were investigated in 372 patients with idiopathic azoospermia or oligospermia and 205 fertile controls.
|
24083421 |
2013 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Meta-analysis revealed an association by use of fixed-effects model of MTHFR C677T with the risk of azoospermia.
|
24268703 |
2014 |
|
rs1136410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphic distributions of SNP rs1136410 and rS1805405 were investigated by polymerase chain reaction and restriction fragment length polymorphism analysis in a Chinese cohort including 371 infertile patients with idiopathic azoospermia or oligospermia and 231 controls.
|
25106941 |
2014 |
|
rs2228611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore the relationship between DNMT1 and spermatogenesis impairment, polymorphic distributions of single-nucleotide polymorphisms (SNP) rs16999593, rs2228612 and rs2228611 in DNMT1 were investigated in 342 infertile patients with idiopathic azoospermia or oligospermia and 232 fertile controls in a Chinese population.
|
24631383 |
2014 |
|
rs777919630
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analysis revealed an association by use of fixed-effects model of MTHFR C677T with the risk of azoospermia.
|
24268703 |
2014 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our meta-analysis showed that the MTHFR C677T mutation was a risk factor for male infertility in both azoospermia and oligoasthenoteratozoospermia patients, especially in Asian population.
|
26549413 |
2015 |