|
rs1800440
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Leu432Val polymorphism is associated with ovarian cancer, lung cancer, and endometrial cancer risk; Asn453Ser and Arg48Gly polymorphisms are associated with endometrial cancer risk among Caucasians, Ala119Ser polymorphism is associated with prostate cancer risk, and Ala119Ser polymorphism is associated with breast cancer risk in Caucasians.
|
25475389 |
2015 |
|
rs1056836
|
|
|
0.050 |
GeneticVariation |
BEFREE |
CYP1B1 Leu432Val and Asn453Ser polymorphisms demonstrated an increased and decreased risk for endometrial cancer, respectively.
|
23370603 |
2013 |
|
rs1800440
|
|
|
0.050 |
GeneticVariation |
BEFREE |
CYP1B1 Leu432Val and Asn453Ser polymorphisms demonstrated an increased and decreased risk for endometrial cancer, respectively.
|
23370603 |
2013 |
|
rs1056836
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We found that CYP1B1 gene L432V polymorphism was associated with a significantly increased risk of endometrial cancer (G vs. C: OR=1.23, 95% CI: 1.06-1.43, P=0.007; GC+GG vs. CC:OR=1.24, 95% CI: 1.08-1.43, P=0.003; GC vs. CC: OR=1.16, 95% CI: 1.04-1.29, P=0.009).
|
21191305 |
2011 |
|
rs1800440
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis provides strong evidence that CYP1B1 gene R48G, L432V, and N4</span>53S polymorphisms are associated with endometrial cancer risk, but not A119S.
|
21191305 |
2011 |
|
rs1056836
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Gene-gene interaction between the Arg48Arg (142C > C) and Leu432Val (4326C > G) variants and between Arg48Gly (142C > G) -CYP1B1 and 975C > G -ERalpha as well as Gly48Gly (142G > G)-CYP1B1 and 975C > G-ERalpha increased the risk of endometrial cancer (OR 2.70; 95%CI 1.12-6.49; OR 2.52; 95%CI 1.04-6.11 and OR 3.62; 95%CI 1.27-10.30, respectively).
|
20492382 |
2010 |
|
rs1800440
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The GSTM1 deletion and the variant (GG) genotype of the CYP1B1 rs1800440 polymorphism were associated with a decreased risk of developing endometrial cancer.
|
20381444 |
2010 |
|
rs1056836
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We evaluated the association between the CYP1B1 Leu432Val and CYP1B1 Asn453Ser polymorphisms and the COMT Val158Met polymorphism and invasive endometrial cancer risk in a case-control study nested within the Nurses' Health Study (n = 222 cases, 666 controls).
|
14656940 |
2004 |
|
rs1800440
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We evaluated the association between the CYP1B1 Leu432Val and CYP1B1 Asn453Ser polymorphisms and the COMT Val158Met polymorphism and invasive endometrial cancer risk in a case-control study nested within the Nurses' Health Study (n = 222 cases, 666 controls).
|
14656940 |
2004 |
|
rs2279744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Subgroup analysis showed that rs2279744 (SNP309) was associated with the risk of gynecological cancers in Caucasian and Asian according to the ethnicity and cancer type, especially for endometrial cancer.
|
29480845 |
2018 |
|
rs2279744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, the study found that MDM2 rs2279744 polymorphism was significantly associated with endometrial cancer risk in a Chinese Han population.
|
29096752 |
2017 |
|
rs2279744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The aim of the study was to determine an association of TP53 codon 72 (Arg72Pro, G>C transversion, rs1042522) and MDM2 SNP309 (T>G change, rs2279744) polymorphisms in endometrial cancer (EC) of postmenopausal women, regarding grading and staging of EC.
|
25316267 |
2014 |
|
rs2279744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our pooled data suggest evidence for a major role of MDM2 rs2279744 polymorphism in the carcinogenesis of endometrial cancer, especially among Caucasian populations.
|
24293392 |
2014 |
|
rs4680
|
|
|
0.040 |
GeneticVariation |
BEFREE |
COMT Val158Met was seen to show a decreased risk for endometrial cancer in Asian population.
|
23370603 |
2013 |
|
rs4680
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Although no obvious associations were detected between COMT Val158Met and endometrial cancer susceptibility in the pooled analysis, we noted significantly decreased endometrial cancer risk for Val/Met versus Val/Val, and Met/Met + Val/Met versus Val/Val genetic models in the postmenopausal female (OR = 0.795, 95%CI = 0.656-0.962, P = 0.019; and OR = 0.819, 95%CI = 0.683-0.983, P = 0.032; respectively), and similar results existed in high-quality studies (OR = 0.835, 95%CI = 0.726-0.961, P = 0.012; and OR = 0.853, 95%CI = 0.747-0.974, P = 0.019; respectively).
|
24390993 |
2013 |
|
rs4680
|
|
|
0.040 |
GeneticVariation |
BEFREE |
DNA samples from 150 cases of EC and healthy controls (n = 165) were analyzed by PCR-RFLP to determine the genotypic frequency of four different polymorphic loci on COMT [codon 62 (rs4633), 102 (rs5031015), 136 (rs4818), 158 (rs4680)].
|
18324659 |
2008 |
|
rs4680
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We evaluated the association between the CYP1B1 Leu432Val and CYP1B1 Asn453Ser polymorphisms and the COMT Val158Met polymorphism and invasive endometrial cancer risk in a case-control study nested within the Nurses' Health Study (n = 222 cases, 666 controls).
|
14656940 |
2004 |
|
rs4430796
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Strong significant associations were found between rs4430796 A and the risk of both prostate cancer (OR = 1.247, p = 2.21 × 10<sup>- 77</sup>) and endometrial cancer (OR = 1.217, p = 8.98 × 10<sup>- 16</sup>); the AA, AG genotypes also showed strong significant associations with the risk of prostate cancer (OR1 = 1.517, p = 4.46 × 10<sup>- 22</sup>; OR2 = 1.180, p = 0.002).
|
30053805 |
2018 |
|
rs10012
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Leu432Val polymorphism is associated with ovarian cancer, lung cancer, and endometrial cancer risk; Asn453Ser and Arg48Gly polymorphisms are associated with endometrial cancer risk among Caucasians, Ala119Ser polymorphism is associated with prostate cancer risk, and Ala119Ser polymorphism is associated with breast cancer risk in Caucasians.
|
25475389 |
2015 |
|
rs4430796
|
|
|
0.030 |
GeneticVariation |
BEFREE |
rs4430796 polymorphism of HNF1B gene influences independently the prognosis of EC patients with a potential effect on tumor chemo-sensitivity.
|
25885815 |
2015 |
|
rs605059
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The result showed no significant association between HSD17B1 rs605059 gene polymorphisms and risks of endometrial cancer (AA vs. AG+GG: OR = 1.11, 95% CI = 0.94-1.32; AA+AG vs. GG: OR = 1.79, 95% CI = 0.42-7.52; AG vs. AA+ GG: OR = 0.87, 95% CI = 0.76-1.00; AA vs. GG: OR = 1.43, 95% CI = 0.62-3.30; A vs. G: OR = 1.00, 95% CI = 0.91-1.11) or endometriosis (AA vs. AG+GG: OR = 0.99, 95% CI = 0.75-1.32; AA+AG vs. GG: OR = 1.73, 95% CI = 0.92-3.25; AG vs. AA+ GG: OR = 1.24, 95% CI = 1.00-1.53; AA vs. GG: OR = 1.54, 95% CI = 0.79-2.97; A vs. G: OR = 1.23, 95% CI = 0.90-1.68).
|
26261478 |
2015 |
|
rs1048943
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that there is no association between endometrial cancer risk and the CYP1A1 Ile462Val polymorphism.
|
23098461 |
2012 |
|
rs10012
|
|
|
0.030 |
GeneticVariation |
BEFREE |
An association of CYP1B1 gene R48G polymorphism with endometrial cancer was found [GG vs. GC+CC: odds ratio (OR)=0.55, 95% confidence interval (CI): 0.42-0.73, P<0.0001; GG vs. CC: OR=0.46, 95% CI: 0.23-0.91, P=0.03].
|
21191305 |
2011 |
|
rs1048943
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Similarly, Ile462Val polymorphism was not associated with endometrial cancer risk (for heterozygous Ile/Val vs Ile/Ile carriers: OR = 1.27, 95% CI, 0.78-2.06, random effects; for homozygous Val/Val vs Ile/Ile carriers: OR = 1.16, 95% CI, 0.48-2.81, fixed effects).
|
21270613 |
2011 |
|
rs4430796
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10(-10)) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes.
|
21499250 |
2011 |