|
rs13041247
|
|
|
0.810 |
GeneticVariation |
GWASDB |
SNPs near two genes not previously associated with cleft lip with and without cleft palate (MAFB, most significant SNP rs13041247, with odds ratio (OR) per minor allele = 0.704, 95% CI 0.635-0.778, P = 1.44 x 10(-11); and ABCA4, most significant SNP rs560426, with OR = 1.432, 95% CI 1.292-1.587, P = 5.01 x 10(-12)) and two previously identified regions (at chromosome 8q24 and IRF6) attained genome-wide significance.
|
20436469 |
2010 |
|
rs16260
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results : There was a significant difference between NS-CL/P subjects and control subjects regarding CDH1 rs16260 C > A polymorphism, and the rs16260 AC as well as the rs16260 AA genotypes were associated with NS-CL/P susceptibility (odds ratio [OR] = 3.02, 95% confidence interval [CI] =1.51-6.00, P = .001; and OR = 8.05, 95% CI = 1.72-37.75, P = .002, respectively).
|
23231047 |
2013 |
|
rs572007403
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One novel heterozygous missense mutation in KISS1R, (NM_032551): c.587C>A (p.P196H), was identified in an 18-year-old KS male with cleft lip and dental agenesis who developed sperm after being treated with gonadotropin.
|
26199944 |
2015 |
|
rs13041247
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Non-syndromic cleft lip with or without palate-susceptible loci rs4791774 (A > G) and rs13041247 (T > C) were associated with the risk of supernumerary teeth.
|
31233659 |
2019 |
|
rs4791774
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Non-syndromic cleft lip with or without palate-susceptible loci rs4791774 (A > G) and rs13041247 (T > C) were associated with the risk of supernumerary teeth.
|
31233659 |
2019 |
|
rs12532
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No significant association was found between NSOC and rs3821949 or rs12532 in MSX1 gene, whereas an association was observed between the P147Q variant and cleft lip with cleft palate in the case-control analysis.
|
21689018 |
2011 |
|
rs3821949
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant association was found between NSOC and rs3821949 or rs12532 in MSX1 gene, whereas an association was observed between the P147Q variant and cleft lip with cleft palate in the case-control analysis.
|
21689018 |
2011 |
|
rs642961
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Lack of association between IRF6 polymorphisms (rs2235371 and rs642961) and non-syndromic cleft lip and/or palate in a Brazilian population.
|
19780991 |
2010 |
|
rs2235371
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Lack of association between IRF6 polymorphisms (rs2235371 and rs642961) and non-syndromic cleft lip and/or palate in a Brazilian population.
|
19780991 |
2010 |
|
rs7017252
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs987525
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs987525
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs10956453
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs11506137
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs1155582
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs11994831
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs12546244
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs12546523
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs12547241
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs13265167
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs13274247
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs1372449
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs1372995
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs1432017
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |
|
rs1441994
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.
|
19270707 |
2009 |