|
rs11542041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This explains the significant effect of the apoE gene locus on the variability of plasma lipoprotein concentrations and moreover the implication of apoE alleles in the aetiology of multifactorial forms of hyperlipidaemia e.g. familial type III hyperlipidaemia (apoE2; arg158----cys) and polygenic hypercholesterolaemia (apoE4; cys112----arg).
|
3141688 |
1988 |
|
rs429358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This explains the significant effect of the apoE gene locus on the variability of plasma lipoprotein concentrations and moreover the implication of apoE alleles in the aetiology of multifactorial forms of hyperlipidaemia e.g. familial type III hyperlipidaemia (apoE2; arg158----cys) and polygenic hypercholesterolaemia (apoE4; cys112----arg).
|
3141688 |
1988 |
|
rs268
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggest that the Asn 291-->Ser substitution is likely to be a significant predisposing factor contributing to the expression of different forms of hyperlipidemia when associated with other genetic factors such as the presence of apoE2.
|
7583546 |
1995 |
|
rs573658040
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Digestion with BbvI or Fnu4HI allows for rapid restriction isotyping for the rare apolipoprotein E R145C mutation associated with hyperlipidemia.
|
7735921 |
1995 |
|
rs769455
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Digestion with BbvI or Fnu4HI allows for rapid restriction isotyping for the rare apolipoprotein E R145C mutation associated with hyperlipidemia.
|
7735921 |
1995 |
|
rs267606661
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In relatives of the proband, APOE R112; R251G was consistently found in subjects with both hyperlipidemia and atherosclerosis.
|
9360638 |
1997 |
|
rs140808909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Characterization of apolipoprotein E7 (Glu(244)-->Lys, Glu(245)--->Lys), a mutant apolipoprotein E associated with hyperlipidemia and atherosclerosis.
|
9925654 |
1999 |
|
rs879254840
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Characterization of apolipoprotein E7 (Glu(244)-->Lys, Glu(245)--->Lys), a mutant apolipoprotein E associated with hyperlipidemia and atherosclerosis.
|
9925654 |
1999 |
|
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We determined the age; sex; presence of IRS (1 or more of the following: body mass index of >25, diabetes, or hyperlipidemia); serum iron tests and liver iron concentration (LIC; reference value, <36 micromol/g); liver function test results; C282Y and H63D HFE mutations; and liver histological status.
|
10535879 |
1999 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We determined the age; sex; presence of IRS (1 or more of the following: body mass index of >25, diabetes, or hyperlipidemia); serum iron tests and liver iron concentration (LIC; reference value, <36 micromol/g); liver function test results; C282Y and H63D HFE mutations; and liver histological status.
|
10535879 |
1999 |
|
rs3829462
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results show an association of the missense mutations Val-73-Met and Leu-334-Phe as susceptibility alleles for combined forms of hyperlipidemia.
|
10606208 |
1999 |
|
rs6078
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results show an association of the missense mutations Val-73-Met and Leu-334-Phe as susceptibility alleles for combined forms of hyperlipidemia.
|
10606208 |
1999 |
|
rs1800206
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study examined the effect a polymorphism (L162V) in the gene for peroxisome proliferator activated receptor (PPAR) alpha in the development of non-insulin-dependent diabetes mellitus (type 2 DM), obesity and hyperlipidaemia.
|
11409711 |
2001 |
|
rs4994
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, no major difference was associated with the beta3AR Trp64Arg or FABP2 Ala54Thr polymorphism in terms of type 2 diabetes or hyperlipidemia in young to older Japanese men.
|
11699048 |
2001 |
|
rs1799883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, no major difference was associated with the beta3AR Trp64Arg or FABP2 Ala54Thr polymorphism in terms of type 2 diabetes or hyperlipidemia in young to older Japanese men.
|
11699048 |
2001 |
|
rs773641005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, no major difference was associated with the beta3AR Trp64Arg or FABP2 Ala54Thr polymorphism in terms of type 2 diabetes or hyperlipidemia in young to older Japanese men.
|
11699048 |
2001 |
|
rs121918392
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case of hyperlipidemia with homozygous apolipoprotein E5 (Glu3-->Lys).
|
12069856 |
2002 |
|
rs1341991169
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case of hyperlipidemia with homozygous apolipoprotein E5 (Glu3-->Lys).
|
12069856 |
2002 |
|
rs2230806
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we provide additional evidence that the R219K polymorphism in the ABCA1 gene either directly or as a result of linkage disequilibrium with additional functional variant(s), has a protective effect against CHD and is associated with lower plasma triglycerides in sub-groups of patients with hyperlipidaemia.
|
12700893 |
2003 |
|
rs4994
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To determine whether this SNP affects insulin resistance syndrome associated with type 2 diabetes, we examined its effects on susceptibility to obesity, hyperlipidemia and hypertension in type 2 diabetic subjects and on susceptibility to type 2 diabetes by interaction with other frequent genes involved in lipid metabolism, namely, beta3-adrenergic receptor (b3AR) Trp64Arg, phosphodiesterase 3B (PDE3B) c.1389G>A or lysosomal acid lipase (LAL) Thr-6Pro.
|
12965109 |
2003 |
|
rs4757268
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine whether this SNP affects insulin resistance syndrome associated with type 2 diabetes, we examined its effects on susceptibility to obesity, hyperlipidemia and hypertension in type 2 diabetic subjects and on susceptibility to type 2 diabetes by interaction with other frequent genes involved in lipid metabolism, namely, beta3-adrenergic receptor (b3AR) Trp64Arg, phosphodiesterase 3B (PDE3B) c.1389G>A or lysosomal acid lipase (LAL) Thr-6Pro.
|
12965109 |
2003 |
|
rs2228314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further work is necessary to confirm the role of 1784G>C in the development of hyperlipidemia.
|
15547298 |
2005 |
|
rs150599989
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Identification of a novel C5L2 variant (S323I) in a French Canadian family with familial combined hyperlipemia.
|
16627811 |
2006 |
|
rs920435389
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate logistic regression analysis after adjustments for age, body mass index, present illness (hyperlipidemia and diabetes mellitus), and lifestyle (smoking and drinking) showed -22A>G to have an association with hypertension in men (AA vs. AG+GG: odds ratio=1.27; 95% confidence interval: 1.02-1.57; P=0.030).
|
18075463 |
2007 |
|
rs1805087
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further study is needed to confirm the role of HHcy and MS A2756G mutation in the development of hyperlipidemia.
|
19263808 |
2008 |