|
rs12229654
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
rs2046210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In premenopausal women, two environmental factors (history of breastfeeding, and history of benign breast disease) and four genetic variants (TOX3-rs3803662, ESR1-rs2046210, 8q24-rs13281615, and SLC4A7-rs4973768) were considered to be risk predictors, whereas three environmental factors (body mass index, history of breastfeeding, and hyperlipidemia), serum levels of testosterone and 25-hydroxyvitamin D, and two genetic variants (TOX3-rs3803662 and ESR1-rs2046210) were identified as risk predictors.
|
29029469 |
2017 |
|
rs2107595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup and multifactor dimensionality reduction analyses (MDR) further found the gene-environment interactions among SNP rs2107595, body mass index, type 2 diabetes and hyperlipidemia in CAD risk and the severity of coronary atherosclerosis.
|
27494404 |
2016 |
|
rs632793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup analyses performed by hyperlipidemia (HLP) demonstrated 3 polymorphisms, rs632793 (OR = 0.31, 95% CI 0.1-0.93, P = 0.04), rs198388 (OR = 0.26, 95% CI 0.09-0.79, P = 0.02) and rs198389 (OR = 0.26, 95% CI 0.09-0.80, P = 0.02) were associated with the reduced risk of LVD.
|
25400811 |
2014 |
|
rs2066714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conducted a cross-sectional study to investigate the effects of the adenosine triphosphate-binding cassette transporter 1 (ABCA1) I883M and lipoprotein lipase (LPL) HindIII polymorphisms on lipid levels in patients with hyperlipidemia.A total of 533 patients were enrolled.
|
28891316 |
2018 |
|
rs2230806
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we provide additional evidence that the R219K polymorphism in the ABCA1 gene either directly or as a result of linkage disequilibrium with additional functional variant(s), has a protective effect against CHD and is associated with lower plasma triglycerides in sub-groups of patients with hyperlipidaemia.
|
12700893 |
2003 |
|
rs717620
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Female Chinese patients with hyperlipidemia carrying rs717620 GA/AA genotypes might have reduced benefit from simvastatin treatment.
|
30024814 |
2018 |
|
rs4994
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, no major difference was associated with the beta3AR Trp64Arg or FABP2 Ala54Thr polymorphism in terms of type 2 diabetes or hyperlipidemia in young to older Japanese men.
|
11699048 |
2001 |
|
rs4994
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To determine whether this SNP affects insulin resistance syndrome associated with type 2 diabetes, we examined its effects on susceptibility to obesity, hyperlipidemia and hypertension in type 2 diabetic subjects and on susceptibility to type 2 diabetes by interaction with other frequent genes involved in lipid metabolism, namely, beta3-adrenergic receptor (b3AR) Trp64Arg, phosphodiesterase 3B (PDE3B) c.1389G>A or lysosomal acid lipase (LAL) Thr-6Pro.
|
12965109 |
2003 |
|
rs2066853
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype frequencies of AhR rs2066853 differed significantly between CAD and control subjects, while smoking and hyperlipidemia markedly promoted CAD risk relative to the AhR polymorphism.
|
25620626 |
2015 |
|
rs974389711
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The various genotypes of the ApoA1 G75A SNP influence the efficacy of lipid regulation by pravastatin and policosanol in patients with hyperlipidemia.
|
27323196 |
2016 |
|
rs662799
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Excess risk for low HDL-C and hyperlipidemia was associated with rs662799 genotype alleles of APOA5 SNPs in older Chinese adults.
|
29758349 |
2018 |
|
rs1042034
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele of rs1042034 and the G allele of rs676210 may thus predispose middle-aged and elderly members of the Chinese Yugur population to HL in combination with other genetic or nutritional factors, and could be used as new genetic markers for HL screening.
|
28902930 |
2017 |
|
rs676210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk factors age (P=0.008), body mass index (P<0.0001), GA+GG genotype in rs676210 (P=0.009), and alcohol consumption (P=0.056) contributed strongly to HL development.
|
28902930 |
2017 |
|
rs679899
|
|
|
0.010 |
GeneticVariation |
BEFREE |
APOB polymorphisms were identified using mass spectrometry, and five single nucleotide polymorphisms (rs1042034, rs2163204, rs512535, rs676210, and rs679899) and serum lipids were further analyzed. rs1042034 and rs676210 were significantly associated with HL (P<0.05).
|
28902930 |
2017 |
|
rs11542041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This explains the significant effect of the apoE gene locus on the variability of plasma lipoprotein concentrations and moreover the implication of apoE alleles in the aetiology of multifactorial forms of hyperlipidaemia e.g. familial type III hyperlipidaemia (apoE2; arg158----cys) and polygenic hypercholesterolaemia (apoE4; cys112----arg).
|
3141688 |
1988 |
|
rs121918392
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case of hyperlipidemia with homozygous apolipoprotein E5 (Glu3-->Lys).
|
12069856 |
2002 |
|
rs140808909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Characterization of apolipoprotein E7 (Glu(244)-->Lys, Glu(245)--->Lys), a mutant apolipoprotein E associated with hyperlipidemia and atherosclerosis.
|
9925654 |
1999 |
|
rs267606661
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In relatives of the proband, APOE R112; R251G was consistently found in subjects with both hyperlipidemia and atherosclerosis.
|
9360638 |
1997 |
|
rs429358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This explains the significant effect of the apoE gene locus on the variability of plasma lipoprotein concentrations and moreover the implication of apoE alleles in the aetiology of multifactorial forms of hyperlipidaemia e.g. familial type III hyperlipidaemia (apoE2; arg158----cys) and polygenic hypercholesterolaemia (apoE4; cys112----arg).
|
3141688 |
1988 |
|
rs573658040
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Digestion with BbvI or Fnu4HI allows for rapid restriction isotyping for the rare apolipoprotein E R145C mutation associated with hyperlipidemia.
|
7735921 |
1995 |
|
rs764929617
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the individual or combined effects of PPARA-L162V, PPARG-C161T and APOE polymorphisms on hyperlipidemia in coronary heart disease (CHD) patients.
|
23583468 |
2013 |
|
rs769455
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Digestion with BbvI or Fnu4HI allows for rapid restriction isotyping for the rare apolipoprotein E R145C mutation associated with hyperlipidemia.
|
7735921 |
1995 |
|
rs1444332461
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the distribution of statin therapy correlated gene polymorphism allele CYP2D6*10 (C188T) in Ningxia Hui nationality and to discuss the relationship between the gene polymorphism allele CYP2D6*10 (C188T) and the lipid-lowering efficacy of simvastatin and hyperlipidemia.
|
24156754 |
2014 |
|
rs10748835
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current study was to determine if coronary heart disease, hypertension, and hyperlipidemia were associated with low-level arsenic exposure and AS3MT gene single nucleotide polymorphism (SNP) A35991G (rs10748835) in rural Texas.
|
22341486 |
2012 |