|
rs2306283
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The present study found that the allele frequencies of SLCO1B1 388A>G and 521T>C in Chinese patients with essential hyperlipidemia are comparable to those in healthy Chinese population.
|
20140004 |
2010 |
|
rs2306283
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our conclusion suggests that the interaction between the SLCO1B1 388A>G and 521T>C polymorphisms could be an important genetic determinant of hepatic function and the therapeutic efficiency of simvastatin in Chinese patients with hyperlipidemia.
|
30336686 |
2018 |
|
rs2306283
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The SLCO1B1 521T > C and 388A > G variants were found to be relatively common in Chinese patients with essential hyperlipidemia.
|
23263738 |
2013 |
|
rs4149056
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The SLCO1B1 521T > C and 388A > G variants were found to be relatively common in Chinese patients with essential hyperlipidemia.
|
23263738 |
2013 |
|
rs4149056
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The present study found that the allele frequencies of SLCO1B1 388A>G and 521T>C in Chinese patients with essential hyperlipidemia are comparable to those in healthy Chinese population.
|
20140004 |
2010 |
|
rs4149056
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our conclusion suggests that the interaction between the SLCO1B1 388A>G and 521T>C polymorphisms could be an important genetic determinant of hepatic function and the therapeutic efficiency of simvastatin in Chinese patients with hyperlipidemia.
|
30336686 |
2018 |
|
rs1800206
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the individual or combined effects of PPARA-L162V, PPARG-C161T and APOE polymorphisms on hyperlipidemia in coronary heart disease (CHD) patients.
|
23583468 |
2013 |
|
rs1800206
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study examined the effect a polymorphism (L162V) in the gene for peroxisome proliferator activated receptor (PPAR) alpha in the development of non-insulin-dependent diabetes mellitus (type 2 DM), obesity and hyperlipidaemia.
|
11409711 |
2001 |
|
rs4994
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, no major difference was associated with the beta3AR Trp64Arg or FABP2 Ala54Thr polymorphism in terms of type 2 diabetes or hyperlipidemia in young to older Japanese men.
|
11699048 |
2001 |
|
rs4994
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To determine whether this SNP affects insulin resistance syndrome associated with type 2 diabetes, we examined its effects on susceptibility to obesity, hyperlipidemia and hypertension in type 2 diabetic subjects and on susceptibility to type 2 diabetes by interaction with other frequent genes involved in lipid metabolism, namely, beta3-adrenergic receptor (b3AR) Trp64Arg, phosphodiesterase 3B (PDE3B) c.1389G>A or lysosomal acid lipase (LAL) Thr-6Pro.
|
12965109 |
2003 |
|
rs1042034
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele of rs1042034 and the G allele of rs676210 may thus predispose middle-aged and elderly members of the Chinese Yugur population to HL in combination with other genetic or nutritional factors, and could be used as new genetic markers for HL screening.
|
28902930 |
2017 |
|
rs10455872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Topics enriched for CVD and hyperlipidemia had positive correlations with rs10455872 (P < 0.001), replicating a previous finding.
|
30759150 |
2019 |
|
rs1048943
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hyperlipidemia could modulate the effect of CYP1A1 rs1048943 on the periodontal status of GAgP.
|
31032950 |
2019 |
|
rs10748835
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current study was to determine if coronary heart disease, hypertension, and hyperlipidemia were associated with low-level arsenic exposure and AS3MT gene single nucleotide polymorphism (SNP) A35991G (rs10748835) in rural Texas.
|
22341486 |
2012 |
|
rs11066280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
rs1137101
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Effects of LEP G2548A and LEPR Q223R Polymorphisms on Serum Lipids and Response to Simvastatin Treatment in Chinese Patients With Primary Hyperlipidemia.
|
26984935 |
2017 |
|
rs11542041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This explains the significant effect of the apoE gene locus on the variability of plasma lipoprotein concentrations and moreover the implication of apoE alleles in the aetiology of multifactorial forms of hyperlipidaemia e.g. familial type III hyperlipidaemia (apoE2; arg158----cys) and polygenic hypercholesterolaemia (apoE4; cys112----arg).
|
3141688 |
1988 |
|
rs11575937
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygosity for LMNA R482Q mutation causes FPLD, which is associated with increased risk of hyperlipidemia and hypertension.
|
23313286 |
2013 |
|
rs11615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multiplicative interactions among SNP rs11615, alcohol drinking, history of T2DM, and history of hyperlipidemia could increase 5.06-fold risk of CAD (P = 1.59 × 10<sup>-9</sup>).
|
28743890 |
2017 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MTHFR C677T genetic variant contributes to simvastatin's effects among Chinese subjects with primary hyperlipidemia.
|
23865383 |
2013 |
|
rs121918392
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case of hyperlipidemia with homozygous apolipoprotein E5 (Glu3-->Lys).
|
12069856 |
2002 |
|
rs121964971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, we characterized monocyte heterogeneity in Tg-hCBS apoE(-/-) Cbs(-/-) mice and another severe HHcy mouse model (Tg-S466L Cbs(-/-)) with a disease-relevant mutation (Tg-S466L) that lacks hyperlipidemia.
|
19858416 |
2009 |
|
rs12229654
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
rs1251035592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SLCO1B1 521T > C and 388A > G variants were found to be relatively common in Chinese patients with essential hyperlipidemia.
|
23263738 |
2013 |
|
rs1256046734
|
|
|
0.010 |
GeneticVariation |
BEFREE |
LEPR Q223R polymorphism, but not LEP G2548A, could modulate the efficacy of simvastatin in Chinese patients with primary hyperlipidemia.
|
26984935 |
2017 |