|
rs16901946
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the recessive model, the rs16901946 GG genotype was associated with decreased risk of GC and IGC in males aged ≥60 years.
|
31288430 |
2019 |
|
rs1800566
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Several studies reported that polymorphism C609T (rs1800566) in (NAD(P)H): quinoneoxidoreductase 1 (NQO1) gene is associated with risk to digestive tract (DT) cancers, like esophageal cancer (EC), gastric cancer (GC), and colorectal cancer (CRC).
|
29652514 |
2019 |
|
rs1801133
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the genetic model analysis, we identified that the single-nucleotide polymorphism of the rs1801133 in MTHFR could increase the GC risk in the recessive model (OR = 1.31, 95% CI, 1.01-1.70; p = 0.042) and log-additive model (OR = 1.19, 95% CI, 1.02-1.38; p = 0.025).
|
30884202 |
2019 |
|
rs184003
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<b>Conclusions:</b><i>RAGE</i> gene SNP rs1800625 was significantly associated with gastric cancer risk, and rs1800625 and rs184003 were related to tumor clinical stage, indicating that <i>RAGE</i> gene may be a gastric cancer-susceptibility gene.
|
30719146 |
2019 |
|
rs2241909
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results revealed that AURKA (rs1047972 and rs911160), AURKB (rs2241909 and rs2289590) and AURKC (rs11084490) are associated with a higher risk of GC susceptibility.
|
31521144 |
2019 |
|
rs2289590
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results revealed that AURKA (rs1047972 and rs911160), AURKB (rs2241909 and rs2289590) and AURKC (rs11084490) are associated with a higher risk of GC susceptibility.
|
31521144 |
2019 |
|
rs2295080
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the polymorphisms of the two loci, PIK3R3 rs7536272 and mTOR rs2295080, on the PI3K/AKT/mTOR signaling pathway genes are associated with genetic susceptibility to gastric cancer in Chinese population.
|
29332342 |
2019 |
|
rs3765524
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC.
|
30931333 |
2019 |
|
rs7536272
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the polymorphisms of the two loci, PIK3R3 rs7536272 and mTOR rs2295080, on the PI3K/AKT/mTOR signaling pathway genes are associated with genetic susceptibility to gastric cancer in Chinese population.
|
29332342 |
2019 |
|
rs889312
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Cox regression analysis, log-rank test and Kaplan-Meier method were used to explore the link between MAP3K1 rs889312 variant and overall survival (OS) of GC.
|
31686841 |
2019 |
|
rs911160
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results revealed that AURKA (rs1047972 and rs911160), AURKB (rs2241909 and rs2289590) and AURKC (rs11084490) are associated with a higher risk of GC susceptibility.
|
31521144 |
2019 |
|
rs1016343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the stratification analyses, the recessive model indicated that the rs1016343 TT genotype was significantly associated with decreased GC risk in individuals aged <60 years showing lymph node metastasis (LNM)-negative results.
|
31288430 |
2019 |
|
rs1044432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the nine SNPs, rs11133399 in CLOCK, rs1044432 and rs2279284 in BAML1 were significantly associated with GC overall survival and recurrence-free survival.
|
30843665 |
2019 |
|
rs10509670
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC.
|
30931333 |
2019 |
|
rs1057519847
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology.
|
31207149 |
2019 |
|
rs1057519848
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology.
|
31207149 |
2019 |
|
rs1058808
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Increased risk for GC was observed under the dominant inheritance model for the rs2643194 TT or CT genotypes with an OR of 2.75 (95%CI 1.12-6.75, P=0.023); the rs2934971 TT or GT genotypes with an OR of 2.41 (95%CI 1.01-5.76, P=0.043), and the rs1058808 GG or CG genotypes with an OR of 2.21 (95%CI 1.00-4.87, P=0.046).
|
31116314 |
2019 |
|
rs11084490
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results revealed that AURKA (rs1047972 and rs911160), AURKB (rs2241909 and rs2289590) and AURKC (rs11084490) are associated with a higher risk of GC susceptibility.
|
31521144 |
2019 |
|
rs11133399
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunohistochemical analysis further demonstrated that the genotype of rs11133399 was significantly associated with the expression level of CLOCK in GC tissues, suggesting that this SNP might affect the prognosis of GC through its influence on the expression of CLOCK gene.
|
30843665 |
2019 |
|
rs1126757
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs1126760 (C vs T: OR=1.39, 95% CIs=1.13-1.70, <i>P</i>=0.002) and rs1126757 (C vs T: OR=0.82, 95% CIs=0.72-0.93, <i>P</i>=0.002) were significantly associated with susceptibility of GC.
|
31686851 |
2019 |
|
rs1126760
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs1126760 (C vs T: OR=1.39, 95% CIs=1.13-1.70, <i>P</i>=0.002) and rs1126757 (C vs T: OR=0.82, 95% CIs=0.72-0.93, <i>P</i>=0.002) were significantly associated with susceptibility of GC.
|
31686851 |
2019 |
|
rs11655237
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b> Our results indicate that LINC00673 rs11655237 is associated with an increased GC risk, possibly by down-regulating LINC00673 expression through creating a miR-1231 binding site.
|
31118802 |
2019 |
|
rs121434568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology.
|
31207149 |
2019 |
|
rs12416605
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs12416605:C>T in MIR938 associates with gastric cancer through affecting the regulation of the CXCL12 chemokine gene.
|
31273931 |
2019 |
|
rs13252298
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs13252298 GG genotype in the recessive model showed increased GC risk in subjects aged ≥60 years showing LNM-positive results and those aged ≥60 years in tumor stage III.
|
31288430 |
2019 |