|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
hOGG1 Ser326Cys polymorphism, interaction with environmental exposures, and gastric cancer risk in Japanese populations.
|
15596047 |
2004 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the association between Ser326Cys human oxoguanine glycosylase 1 (hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori (H. pylori) eradication.
|
20845517 |
2010 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No significant association was found for either allele or genotype with gastric cancer (odds ratio [OR]=0.96; 95% confidence interval [95% CI]: 0.82-1.13; P=0.66), and this was also the case after combining 326Ser/Cys and 326Ser/Ser genotypes together (OR=0.87; 95% CI: 0.63-1.20; P=0.40), or 326Cys/Cys and 326Ser/Cys together (OR=1.03; 95% CI: 0.87-1.22; P=0.72).
|
22471492 |
2011 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Taken together, the results suggest that the hOGG1 Ser326Cys polymorphism may contribute to susceptibility to gastric cancer.
|
22343785 |
2012 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphic variants of base excision repair (APE1-D148E, XRCC1-R194W, XRCC1-R399Q and OGG1-S326C), nucleotide excision repair (XPC-PAT, XPA-23G>A, ERCC1-19007T>C and XPD-L751Q), recombination (XRCC3-T241M) and alkylation damage reversal (MGMT-L84F) were tested for their potential role in the development of GC by using logistic regression models.
|
20817763 |
2010 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The significant effects of hOGG1 Ser326Cys polymorphism on colorectal, breast, bladder, prostate, esophageal, and gastric cancer were not detected.
|
22114677 |
2011 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis showed there was no association between hOGG1 rs1052133 and GC.
|
28415729 |
2017 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined the distribution of the hOGG1 Ser326Cys polymorphism and its presumed correlation with gastric cancer risk in two case-control studies of different ethnic groups in São Paulo, Brazil.
|
11448535 |
2001 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although smokers and high salted tea drinkers themselves were at higher risk for gastric cancer (OR=8.975, P=0.0001; OR=14.778, P=0.0001), interaction with OGG1 Ser326Cys did not further modulate the risk.
|
20593951 |
2010 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This variant decreased the gene promoter activity by approximately 17.8% (P = 0.041) and exhibited a synergistic effect with the missense mutation p.Ser326Cys of hOGG1 by enhancing susceptibility to gastric cancers.
|
21822670 |
2011 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis provided evidence that hOGG1 S326C genetic polymorphism was not associated with increased risk of gastric cancer.
|
22296498 |
2012 |
|
rs11614913
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, the results suggested that the miR-146a rs2910164 polymorphism was related to gastric cancer risk in Asians but not in Caucasians, and no distinct correlation seemed to exist between the miR-196a-2 rs11614913 polymorphism and the risk of gastric cancer.
|
26345790 |
2015 |
|
rs11614913
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results demonstrated that miR-196a2 rs11614913 was significantly associated with a decreased cancer risk, in particular with a decreased risk for colorectal cancer and gastric cancer, or for Asian population subgroup.
|
29371991 |
2017 |
|
rs11614913
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs2910164/rs2292832/rs11614913</span> CTT and CCT haplotypes seems to have a protective role against GC (p = 0.002 and p = 0.001, respectively).
|
24379078 |
2014 |
|
rs11614913
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There is no significant association between rs2910164 and rs11614913 and the risk of human gastric cancer.
|
26215064 |
2015 |
|
rs11614913
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We analyzed the correlations of rs11614913 polymorphism with gastric cancer susceptibility in test and validation sets.
|
23423813 |
2013 |
|
rs11614913
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our studies suggested that the miR-146a rs2910164 polymorphism might marginally contribute to a decreased risk of gastric cancer, especially in Caucasians, whereas the miR-196a2 rs11614913 polymorphism might not be associated with susceptibility to GC.
|
26406571 |
2015 |
|
rs11614913
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs11614913 (T>C), rs2910164 (C>T), and rs3746444 (A>G) SNPs were genotyped in 130 advanced GCs performing chemotherapy.
|
25202115 |
2014 |
|
rs11614913
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that rs11614913 and rs2910164 do not pose general cancer risk, but rs11614913 may influence gastric cancer in Japanese elderly population.
|
24716941 |
2014 |
|
rs11614913
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of gastric cancer (GC) and peptic ulcer diseases, and with the severity of Helicobacter pylori-induced gastritis in Japanese population.
|
21073609 |
2010 |
|
rs11614913
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between genetic polymorphism of miR-196a-2 (rs11614913) and risk of gastric cancer, a hospital-based case-control study was conducted in a Chinese population.
|
19834808 |
2010 |
|
rs11614913
|
|
|
0.100 |
GeneticVariation |
BEFREE |
By logistic regression analysis, we found that the CC genotype of rs11614913</span> was associated with an increased risk of gastric cancer</span> in a codominant model (OR = 2.68, 95%CI = 1.17-6.44).
|
27173281 |
2016 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Compared with the CC genotype of MTHFR C677T, the TT genotype was significantly associated with a decreased risk of gastric cancer when the analysis was adjusted for other potential risk factors.
|
24615072 |
2014 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase 677C>T polymorphism and gastric cancer susceptibility in Mexico.
|
16359859 |
2006 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the possible relations between the TS 3'-UTR and MTHFR C677T polymorphisms and environmental factors impacting on risk of esophageal and stomach cancers, we conducted a case-control study in a high incidence region of China for these cancers.
|
15244514 |
2004 |