|
rs2104286
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Here, we show that the IL2RA genotypes differentially affects soluble IL-2RA (sIL-2RA) levels in MS cases vs healthy controls; the two variants associated with MS (rs12722489 and rs2104286) account for 15 and 18% of the total variance in log(10)-transformed sIL-2RA concentration in control subjects but less so in subjects with MS (2 and 5%), suggesting that perturbations associated with disease or treatment may influence sIL-2RA levels in subjects with MS.
|
19155502 |
2009 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
BEFREE |
IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways?
|
21911588 |
2011 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association studies have identified an association between two intronic single nucleotide polymorphisms (SNPs), rs12722489 and rs2104286, in the interleukin-2 receptor alpha-chain gene (IL2RA) and susceptibility to multiple sclerosis (MS).
|
21239413 |
2011 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Correlations were strongest in HCs suggesting that immunological alterations may obscure the role of the IL2RA SNP rs2104286 in established MS.
|
28511943 |
2017 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The gene polymorphisms at the loci of IL2RA rs2104286 and rs12722489 are closely associated with susceptibility to MS in the Han and Hui nationalities.
|
30352019 |
2018 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
rs2104286
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
rs2104286
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
|
rs2104286
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We replicated the association of only one (rs2104286) of the two IL2RA SNPs identified in the recently performed genome-wide association study of MS.
|
19125193 |
2009 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Although not statistically significant, the effect of IL2RA (rs2104286) in patients without a family history of MS indicates that the genetic components for familial and sporadic disease are perhaps distinct.
|
24770783 |
2014 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We observed that MS-associated <i>IL2RA</i> SNPs rs2104286 and rs11256593 are associated with expression of CD25 in CD4<sup>+</sup> but not CD8<sup>+</sup> T cells.
|
31242590 |
2019 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
BEFREE |
It was concluded that both of the IL2RA gene polymorphisms, rs2104286 and rs12722489, were associated with increased susceptibility to MS.
|
22117963 |
2011 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that the rs2104286 A allele is associated with increased MS risk in both Caucasians and Asians, whereas the rs12722489 C allele is associated with elevated MS risk in Caucasians but not in Asians.
|
29648897 |
2018 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition, the significant association between PrMS and rs6897932 indicates that IL7R may not be disease-causing but a determinant of disease course.
|
24770783 |
2014 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition, whereas no association was found between the alternative splicing SNP, rs6897932, and MS, a significant link was found between the promoter SNP, rs11567685, and MS.
|
24166352 |
2014 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The IL-7Rα single nucleotide polymorphism rs6897932 is associated with an increased risk for multiple sclerosis (MS).
|
22262655 |
2012 |
|
rs6897932
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
rs6897932
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This revealed an association between IL7R T244I and MS (P < 0.00001 for the C-allele and the C/C genotype; P = 0.0004 for the C/C + C/T genotype), no heterogeneity was observed (allele C: P = 0.07; genotype C/C: P = 0.10).
|
21161391 |
2011 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
No significant association between the IL7RA C/T (rs6897932) and IL12B A1188C (rs3212227) gene polymorphisms and MS susceptibility was observed.
|
30069682 |
2018 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Moreover, we revealed for the first time that rs6897932 in IL7Ra gene is associated with the progression of MS, evaluated by MSSS scores.
|
25903732 |
2015 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study suggested that the IL7R C allele was associated with an increased risk of MS and larger-scale studies of populations are needed to explore the roles played by the IL7R T244I polymorphism during the pathogenesis of MS.
|
27188999 |
2016 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
It was demonstrated that the IL7R T244I polymorphism was associated with susceptibility to MS.
|
27456877 |
2016 |