|
rs1064395
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs linked to MS pathology-associated genes showed a significant association with either proportion of active lesions (rs3130253/MOG), incidence of cortical gray matter lesions (rs1064395/NCAN) or the proportion of remyelinated lesions (rs5742909/CTLA4).
|
31228212 |
2020 |
|
rs11957313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs linked to MS clinical severity showed a significant association between the genotype and either the proportion of active lesions (rs2234978/FAS and rs11957313/KCNIP1) or the proportion of mixed active/inactive lesions (rs8056098/CLEC16A).
|
31228212 |
2020 |
|
rs2234978
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs linked to M</span>S clinical severity showed a significant association between the genotype and either the proportion of active lesions (rs2234978/FAS and rs11957313/KCNIP1) or the proportion of mixed active/inactive lesions (rs8056098/CLEC16A).
|
31228212 |
2020 |
|
rs2501432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant genetic association was observed between Q63R polymorphism and MS.
|
31407233 |
2020 |
|
rs35761398
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant genetic association was observed between Q63R polymorphism and MS.
|
31407233 |
2020 |
|
rs41423247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, the long non-coding RNA (lncRNA) <i>growth arrest specific 5</i> (<i>GAS5</i>) interacts with GR through binding to the DNA-binding domain (DBD) region and reduces GR transcriptional activity.<b>Methods:</b> The purpose of our study was to evaluate the association between MS and polymorphisms within <i>NR3C1</i> (rs6189/6190, rs56149945, rs41423247) and <i>GAS5</i> (rs55829688) genes in 300 relapsing-remitting MS patients and 300 healthy subjects.<b>Results:</b> We demonstrated significant differences in distribution of genotype, allele and haplotype frequencies of rs6189, rs41423247 and rs55829688 between the study groups.<b>Conclusion:</b> Our data may suggest that rs6189, rs41423247 and rs55829688 are associated with the increased risk of MS development.
|
31724909 |
2020 |
|
rs55829688
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, the long non-coding RNA (lncRNA) <i>growth arrest specific 5</i> (<i>GAS5</i>) interacts with GR through binding to the DNA-binding domain (DBD) region and reduces GR transcriptional activity.<b>Methods:</b> The purpose of our study was to evaluate the association between MS and polymorphisms within <i>NR3C1</i> (rs6189/6190, rs56149945, rs41423247) and <i>GAS5</i> (rs55829688) genes in 300 relapsing-remitting MS patients and 300 healthy subjects.<b>Results:</b> We demonstrated significant differences in distribution of genotype, allele and haplotype frequencies of rs6189, rs41423247 and rs55829688 between the study groups.<b>Conclusion:</b> Our data may suggest that rs6189, rs41423247 and rs55829688 are associated with the increased risk of MS development.
|
31724909 |
2020 |
|
rs5742909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs linked to MS pathology-associated genes showed a significant association with either proportion of active lesions (rs3130253/MOG), incidence of cortical gray matter lesions (rs1064395/NCAN) or the proportion of remyelinated lesions (rs5742909/CTLA4).
|
31228212 |
2020 |
|
rs6189
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, the long non-coding RNA (lncRNA) <i>growth arrest specific 5</i> (<i>GAS5</i>) interacts with GR through binding to the DNA-binding domain (DBD) region and reduces GR transcriptional activity.<b>Methods:</b> The purpose of our study was to evaluate the association between MS and polymorphisms within <i>NR3C1</i> (rs6189/6190, rs56149945, rs41423247) and <i>GAS5</i> (rs55829688) genes in 300 relapsing-remitting MS patients and 300 healthy subjects.<b>Results:</b> We demonstrated significant differences in distribution of genotype, allele and haplotype frequencies of rs6189, rs41423247 and rs55829688 between the study groups.<b>Conclusion:</b> Our data may suggest that rs6189, rs41423247 and rs55829688 are associated with the increased risk of MS development.
|
31724909 |
2020 |
|
rs8056098
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs linked to MS clinical severity showed a significant association between the genotype and either the proportion of active lesions (rs2234978/FAS and rs11957313/KCNIP1) or the proportion of mixed active/inactive lesions (rs8056098/CLEC16A).
|
31228212 |
2020 |
|
rs879761216
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant genetic association was observed between Q63R polymorphism and MS.
|
31407233 |
2020 |
|
rs10492503
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant correlation was observed in the presence of allele T of rs10492503 polymorphism inGPC5 gene with sex and age of MS onset.
|
30818222 |
2019 |
|
rs1051312
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, GC haplotype for rs3746544 of SNAP-25 gene and rs1051312 of SNAP-25 gene were associated with an increased risk for multiple sclerosis (p=0.022).
|
30582321 |
2019 |
|
rs11256593
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed that MS-associated <i>IL2RA</i> SNPs rs2104286 and rs11256593 are associated with expression of CD25 in CD4<sup>+</sup> but not CD8<sup>+</sup> T cells.
|
31242590 |
2019 |
|
rs117026326
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed a significant genetic association between the variant rs117026326 and NMOSD (P = 1.09 × 10<sup>-11</sup>, OR = 2.535), however, the association with MS was not significant (P = .4289, OR = 1.129).
|
31520790 |
2019 |
|
rs11833579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we genotyped two NINJ2 single nucleotide polymorphisms (SNPs) namely rs11833579 and rs3809263 in a population of Iranian patients with MS as well as healthy individuals.
|
31292852 |
2019 |
|
rs12429256
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study also suggests that Rgcc overexpression in OL lineage cells may be a key cellular mechanism of rs17594362 and rs12429256 for MS.
|
31509193 |
2019 |
|
rs1258159645
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A polymorphic form of NQO1 (p.P187S) is associated with increased cancer risk and certain neurological disorders (such as multiple sclerosis and Alzheimer´s disease), possibly due to its roles in the antioxidant defence. p.P187S has greatly reduced FAD affinity and stability, due to destabilization of the flavin binding site and the C-terminal domain, which leading to reduced activity and enhanced degradation.
|
31091472 |
2019 |
|
rs1342326
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The level of IL33 was significantly higher in asthma and MS patients compared to the control group (P< 0.001- P<0.001).The frequency distribution of the genotype in rs1342326 variant of IL-33 gene in patients with asthma, MS and healthy subjects was not significantly different (P>0.05).
|
30950351 |
2019 |
|
rs1569061
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CC, syntaxin rs1569061 1A gene for 33-bp promoter region TC haplotypes, and synaptotagmin XI gene were found to be associated with an increased risk for multiple sclerosis (p=0.012).
|
30582321 |
2019 |
|
rs16870005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, the association of <i>C6orf10</i> rs16870005 (Ala431Thr) with MS did not depend on its linkage disequilibrium with the <i>HLA-DRB1</i> locus.
|
31297130 |
2019 |
|
rs17594362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study also suggests that Rgcc overexpression in OL lineage cells may be a key cellular mechanism of rs17594362 and rs12429256 for MS.
|
31509193 |
2019 |
|
rs17849781
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A polymorphic form of NQO1 (p.P187S) is associated with increased cancer risk and certain neurological disorders (such as multiple sclerosis and Alzheimer´s disease), possibly due to its roles in the antioxidant defence. p.P187S has greatly reduced FAD affinity and stability, due to destabilization of the flavin binding site and the C-terminal domain, which leading to reduced activity and enhanced degradation.
|
31091472 |
2019 |
|
rs1805087
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Relationship between genetic polymorphisms MTHFR (C677T, A1298C), MTR (A2756G) and MTRR (A66G) genes and multiple sclerosis: a case-control study.
|
31038186 |
2019 |
|
rs1979277
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, genotypes TT (SHMT1 rs4925166), CC (ERG rs2836425), GG (MAZ rs34286592), and GG (SHMT1 rs1979277) had the highest negative association (protective effect) with MS, respectively.
|
30456721 |
2019 |