|
rs1004446
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
rs10045431
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Replication extended to the following polymorphisms: PKN2 (rs305217), GTF2B (rs7538427), EPHA4 (rs1517440), YTHDF3 (rs12115114), ANKFN1 (rs17758761) and PTPRM (rs4798571), which did not reach the threshold of significance in a follow-up of the first genome-wide association study (GWAS) conducted in multiple sclerosis; TMEM39A (rs1132200), which appeared as a newly identified susceptibility gene in the same study; a gene previously reaching GWAS significance in Italy, CBLB (rs9657904); IL12B (rs6887695, rs10045431), a susceptibility gene shared by diverse autoimmune diseases and, finally, another gene showing inconclusive association with multiple sclerosis, CNR1 (rs1049353).
|
22194214 |
2012 |
|
rs10045431
|
|
|
0.710 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
rs1014486
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
|
rs10201872
|
|
|
0.810 |
GeneticVariation |
BEFREE |
To confirm the association of this functional variant with MS and to compare it with the best-associated variant previously reported by GWAS (rs10201872), a case-control study including 4384 MS patients and 3197 controls was performed.
|
26152201 |
2015 |
|
rs10201872
|
|
A |
0.810 |
GeneticVariation |
GWASCAT |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
rs10201872
|
|
A |
0.810 |
GeneticVariation |
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
rs1021156
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified 2 non-human leucocyte antigen (HLA; rs12599600 and rs1021156) and 1 HLA (rs9266773) SNP predicting both MS and relapse risk.
|
27559181 |
2016 |
|
rs1021156
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The purpose of this study was to examine whether the monocyte chemoattractant protein-1 (MCP-1) promoter -2518 A/G polymorphism (rs1024611) is associated with susceptibility to vasculitis, rheumatoid arthritis (RA), or multiple sclerosis (MS).
|
27064875 |
2016 |
|
rs1036207
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
|
rs10411936
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
rs10411936
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
rs1044165
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We performed an association study of polymorphous variants of MIR146A rs2910164, MIR196A2 rs11614913, MIR499A rs3746444 MIR223 rs1044165 and their combinations with MS risk and severity.
|
26305248 |
2015 |
|
rs10466829
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
rs10466829
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
rs10488631
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
rs104895080
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Concurrent TNFRSF1A R92Q and pyrin E230K mutations in a child with multiple sclerosis.
|
20876156 |
2010 |
|
rs104895094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Frequencies of the pyrin E148Q and K695R mutations were not statistically different between MS group 2 and controls but they occurred with a surprisingly high frequency in the German population.
|
22337722 |
2012 |
|
rs104895271
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe 3 families (8 subjects) with the TNFRSF1A D12E substitution and TRAPS-related symptoms, in 4 cases associated with the autoimmune diseases multiple sclerosis and rheumatoid arthritis.
|
23322460 |
2013 |
|
rs10492503
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant correlation was observed in the presence of allele T of rs10492503 polymorphism inGPC5 gene with sex and age of MS onset.
|
30818222 |
2019 |
|
rs10492972
|
|
|
0.830 |
GeneticVariation |
BEFREE |
We applied the equivalence method to genetic data to confirm that an association between the KIF1B (kinesin family member1B) rs10492972 allele and multiple sclerosis (MS), reported in Nature Genetics in 2008, is present neither in eight data sets of cases and controls nor in three independent data sets of the International Multiple Sclerosis Genetic Consortium.
|
21594895 |
2011 |
|
rs10492972
|
|
C |
0.830 |
GeneticVariation |
GWASCAT |
Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.
|
18997785 |
2008 |
|
rs10492972
|
|
C |
0.830 |
GeneticVariation |
GWASDB |
Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.
|
18997785 |
2008 |
|
rs10492972
|
|
|
0.830 |
GeneticVariation |
BEFREE |
The objective of this study is to test the association of the rs10492972 C allelic variant of KIF1B gene in a large Italian cohort of patients with primary progressive and progressive relapsing MS (PPMS and PRMS), which represents a subtype of MS mainly driven by neurodegenerative phenomena.
|
20067515 |
2010 |