|
rs3130253
|
|
|
0.040 |
GeneticVariation |
BEFREE |
It is therefore unlikely that the MOG Val 145 Ile variant is responsible for genetic susceptibility to MS.
|
9493637 |
1997 |
|
rs80265967
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Loss of synchrony was similar in D90A and MS patients, but the threshold, number of excess bins, and duration differed significantly (P < 0.0057), which suggests that either axonal loss or demyelination can result in delayed and desynchronized primary peaks.
|
11150970 |
2001 |
|
rs5443
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the first time, we studied the frequencies of a recently described C825T polymorphism in the G-protein encoding gene for the beta3 subunit (GNB3) together with frequencies of a 32-base-pair deletion in the CCR5 gene (delta32 CCR5) in patients with MS (n = 253: relapsing-remitting (RR), n = 124 and chronic progressive course, n = 129).
|
12270649 |
2002 |
|
rs2857766
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Polymorphism Val 142 Leu, which is linked to nt 571+68A-->G (IVS 4), resulted under-represented in MS patients.
|
12446029 |
2002 |
|
rs112913018
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A detailed analysis of the coding sequences of myelin oligodendrocyte glycoprotei (MOG) gene was performed in multiple sclerosis (MS) patients and in control individuals and three new polymorphisms are described: T636C, nt 571+77C-->T (IVS 4), and nt 710-44A-->G (IVS 6).
|
12446029 |
2002 |
|
rs5498
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis.
|
12590979 |
2003 |
|
rs4986790
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study we determined whether genetic variants of toll-like receptor (TLR) 4, which confer substantial differences in the inflammation elicited by bacterial lipopolysaccharide, are related to the development of MS. We found no differences in the frequencies of the cosegregating TLR4 Asp299Gly and Thr399Ile polymorphisms between Austrian MS patients (11.6%) and age-matched controls (13.7%).
|
12622779 |
2003 |
|
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study we determined whether genetic variants of toll-like receptor (TLR) 4, which confer substantial differences in the inflammation elicited by bacterial lipopolysaccharide, are related to the development of MS. We found no differences in the frequencies of the cosegregating TLR4 Asp299Gly and Thr399Ile polymorphisms between Austrian MS patients (11.6%) and age-matched controls (13.7%).
|
12622779 |
2003 |
|
rs148561683
|
|
|
0.010 |
GeneticVariation |
BEFREE |
None of the four newly identified nucleotide substitutions, namely C77T (Pro59Pro) in exon 4, G69C (Asp121His) in exon 5, T127A (Ile187Asn) and A138G (Thr191Ala) in exon 6, was significantly associated to MS.
|
12864992 |
2003 |
|
rs4915154
|
|
|
0.010 |
GeneticVariation |
BEFREE |
None of the four newly identified nucleotide substitutions, namely C77T (Pro59Pro) in exon 4, G69C (Asp121His) in exon 5, T127A (Ile187Asn) and A138G (Thr191Ala) in exon 6, was significantly associated to MS.
|
12864992 |
2003 |
|
rs148038936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently a polymorphism (C77G) in exon 4 of CD45 causing abnormal CD45 splicing and a point mutation affecting CD45 dimerization were implicated in multiple sclerosis in humans and lymphoproliferation and autoimmunity in mice respectively.
|
14630980 |
2004 |
|
rs753269867
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, heterozygous state of CD45 exon 4 mutation (C77C wild type and C77G mutant) was reported to be associated with development of multiple sclerosis in German patients and increased susceptibility to HIV-1 infection in the United Kingdom.
|
14641523 |
2003 |
|
rs1800562
|
|
|
0.020 |
GeneticVariation |
BEFREE |
One C282Y-homozygous female was identified who had MS and was being treated for symptoms of iron overload.
|
15014978 |
2004 |
|
rs1275561861
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One C282Y-homozygous female was identified who had MS and was being treated for symptoms of iron overload.
|
15014978 |
2004 |
|
rs231775
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The results of our study indicate that CTLA-4 (A49G) exon 1 polymorphism is associated with MS progression.
|
15180809 |
2004 |
|
rs1800470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TGFB1 T+869C (Leu10Pro) gene polymorphism is associated with MS susceptibility, especially in males, and with a more destructive course of the disease as illustrated by MRI.
|
15450129 |
2004 |
|
rs5938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the association of the platelet-activating factor receptor (PAFR) gene polymorphism (A224D) with the susceptibility and severity of multiple sclerosis (MS) in a Japanese population.
|
15748960 |
2005 |
|
rs4986790
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Therefore, we investigated the role of an Asp299Gly mutation in the TLR-4 receptor in 890 MS patients with multiple sclerosis and 350 healthy controls.
|
15932772 |
2005 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF-Val66Met-polymorphism leads to altered intracellular transport and secretion of BDNF, and is thus a logical candidate for a gene that influences susceptibility and, more specifically, the clinical course of multiple sclerosis.
|
16046000 |
2005 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF-Val66Met-polymorphism leads to altered intracellular transport and secretion of BDNF, and is thus a logical candidate for a gene that influences susceptibility and, more specifically, the clinical course of multiple sclerosis.
|
16046000 |
2005 |
|
rs2228315
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In order to determine whether genetic variation in these pivotal molecules influences susceptibility to MS, we genotyped 214 Italian patients compared with 220 Italian controls for three single-nucleotide polymorphisms (SNPs): SELPLG Met62Ile, SELP C-2123G and SELP Thr715Pro.
|
16257118 |
2006 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, we investigated the impact of the BDNF-Val66Met polymorphism on the susceptibility and clinical course in a case-control study of 224 multiple sclerosis (MS) Spanish patients and 177 healthy controls.
|
16356643 |
2006 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, we investigated the impact of the BDNF-Val66Met polymorphism on the susceptibility and clinical course in a case-control study of 224 multiple sclerosis (MS) Spanish patients and 177 healthy controls.
|
16356643 |
2006 |
|
rs3087456
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We analysed whether the single nucleotide polymorphism (SNP) rs3087456 in the promoter of the MHC class II transactivator (MHC2TA) gene is associated with manifestation of rheumatoid arthritis, multiple sclerosis, narcolepsy and Wegener granulomatosis.
|
16426246 |
2006 |
|
rs1217691063
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Thus, the C677T mutation of the MTHFR gene may influence MS susceptibility.
|
16564429 |
2006 |