|
rs368243788
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Arg113His mutation of vanishing white matter is not present in multiple sclerosis.
|
17439913 |
2007 |
|
rs4149584
|
|
|
0.100 |
GeneticVariation |
BEFREE |
R92Q mutation was more frequent in MS patients as compared to controls.
|
21567205 |
2012 |
|
rs423674
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs423674, or its genetic proxies, may influence MS risk by modulating SOCS1 expression in a cell-specific manner and by influencing dendritic cell function.
|
25623250 |
2015 |
|
rs3735007
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study of more than 1,000 individuals from mainland Italy indicated that the Thr851Ile SNP is significantly associated with susceptibility to multiple sclerosis (MS) (odds ratio [OR] = 1.47, 95% confidence intervals [CI]: 1.08-1.99, P = 0.011).
|
22319148 |
2012 |
|
rs11352835
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case/control study for MS indicated that rs11352835</span> is associated with disease susceptibility (for an allelic model with the deleted allele predisposing to MS, OR 1.27, 95% CI 1.072-1.513, p = 0.010).
|
21735172 |
2012 |
|
rs9939609
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A cohort of 200 MS patients (135 females and 65 males) were genotyped for the FTO rs9939609 polymorphism.
|
31836807 |
2019 |
|
rs682626
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A combination of the previous MS-associated haplotype and two additional SNPs was associated with anti-CCP negative RA (alleles G-G-A-A of rs682626-rs2546133-rs2617822-rs12979659, OR=1.13, P=1.27 × 10<sup>-5</sup>).
|
28053322 |
2017 |
|
rs2546133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A combination of the previous MS-associated haplotype and two additional SNPs was associated with anti-CCP negative RA (alleles G-G-A-A of rs682626-rs2546133-rs2617822-rs12979659, OR=1.13, P=1.27 × 10<sup>-5</sup>).
|
28053322 |
2017 |
|
rs2617822
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A combination of the previous MS-associated haplotype and two additional SNPs was associated with anti-CCP negative RA (alleles G-G-A-A of rs682626-rs2546133-rs2617822-rs12979659, OR=1.13, P=1.27 × 10<sup>-5</sup>).
|
28053322 |
2017 |
|
rs12979659
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A combination of the previous MS-associated haplotype and two additional SNPs was associated with anti-CCP negative RA (alleles G-G-A-A of rs682626-rs2546133-rs2617822-rs12979659, OR=1.13, P=1.27 × 10<sup>-5</sup>).
|
28053322 |
2017 |
|
rs3748816
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A combined analysis of the nsSNP screen and replication data provides evidence implicating a novel additional locus, rs3748816 in membrane metalloendopeptidase-like 1 (MMEL1; odds ratio=1.16, P=3.54 × 10⁻⁶) in MS susceptibility.
|
20574445 |
2010 |
|
rs112913018
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A detailed analysis of the coding sequences of myelin oligodendrocyte glycoprotei (MOG) gene was performed in multiple sclerosis (MS) patients and in control individuals and three new polymorphisms are described: T636C, nt 571+77C-->T (IVS 4), and nt 710-44A-->G (IVS 6).
|
12446029 |
2002 |
|
rs1254566330
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A functional polymorphism within the V-type immunoglobulin domain of RAGE gene, p.82G>S (c.557G>A), has been shown to affect ligand binding affinity and thus may affect susceptibility to MS.
|
21511691 |
2011 |
|
rs9657904
|
|
|
0.830 |
GeneticVariation |
BEFREE |
A genome-wide association scan of approximately 6.6 million genotyped or imputed variants in 882 Sardinian individuals with multiple sclerosis (cases) and 872 controls suggested association of CBLB gene variants with disease, which was confirmed in 1,775 cases and 2,005 controls (rs9657904, overall P = 1.60 x 10(-10), OR = 1.40).
|
20453840 |
2010 |
|
rs4149584
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A genome-wide association study has identified the R92Q variant of the TNFRSF1A gene as a new susceptibility locus for multiple sclerosis.
|
19794511 |
2009 |
|
rs3129934
|
|
T |
0.810 |
GeneticVariation |
GWASDB |
A genome-wide association study in progressive multiple sclerosis.
|
22457343 |
2012 |
|
rs3129934
|
|
T |
0.810 |
GeneticVariation |
GWASCAT |
A genome-wide association study in progressive multiple sclerosis.
|
22457343 |
2012 |
|
rs13279485
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |
|
rs13279485
|
|
|
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |
|
rs2920001
|
|
|
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |
|
rs2920001
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |
|
rs4271113
|
|
|
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |
|
rs4271113
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |
|
rs533259
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |
|
rs533259
|
|
|
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |