|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val158Met polymorphism (rs4680) does not appear to be involved in predisposition to tension-type headache; however, this genetic factor may be involved in the pathogenesis expression of CTTH, as greater pressure pain sensitivity and higher depressive levels were found in CTTH carrying the Met/Met genotype.
|
30614828 |
2019 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association between COMT Val158Met polymorphism (rs4680) and the inter-individual differences in the response to opioid analgesic therapy was investigated in a cohort of 87 Italian paediatric patients receiving opioids for cancer pain (STOP Pain study).
|
30704436 |
2019 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients with the COMT G472A-AA genotype (rs4680) and KCNJ6 A1032G-A allele (rs2070995) CLBP responded differently to opioid titration, with higher pain intensity requiring higher dosing.
|
31269327 |
2019 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The AA genotype of rs4680 or A_T_C_A/ A_T_C_A (rs6269_rs4633_ rs4818_rs4680) diplotype of COMT, combined with the AG genotype of OPRM1 A118G, showed significantly increased pressure pain threshold from butorphanol.
|
31806881 |
2019 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val158Met rs4680 polymorphism does not appear to be involved in predisposition to suffer from migraine; however, this genetic factor may be involved in the phenotypic expression of chronic migraine, as anxiety, depression, and widespread pressure pain sensitivity were greater in those women with chronic, but not episodic, migraine with the Met/Met genotype.
|
30481348 |
2019 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In comparison, two pain-related gene SNPs (OPRM1 [rs1799971] and COMT [rs4818]) interacted with psychological factors to predict four shoulder impairment phenotypes (abduction: 5-day average loss; strength loss: 5-day average, peak, and relative loss).
|
30425562 |
2018 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism of the μ-opioid receptor, OPRM1 A118G, has been associated with greater drug and alcohol use, increased sensitivity to pain, and reduced sensitivity to the antinociceptive effects of opiates.
|
28939474 |
2018 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, given the prominent role of the opioid system in pain signaling, we investigated the effects of acute alcohol exposure on PIP5K1C expression in humanized transgenic mice for the μ-opioid receptor that included the OPRM1 A118G polymorphism, a widely used mouse model to study analgesic response to opioids in pain.
|
29667742 |
2018 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This OPRM1 A118G-DPMS interaction is one plausible neurological mechanism underlying the individual differences in pain experience.
|
28057931 |
2017 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For patients with no copies of the LPS haplotype, AA of OPRM1 A118G was significantly associated with higher pain scores compared to the variant AG/GG.
|
27903758 |
2017 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, the data demonstrated that the rare allele of MMP9 rs17576 was associated with poor pain recovery, whereas the rare allele of OPRM1 rs1799971 was associated with better pain recovery at 5-year follow-up in the LBP and LRP patients.
|
28471875 |
2017 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequencies of COMT rs4680 "A" allele were higher in PD patients with pain than those without pain (46.1% vs. 31.1%, P < 0.01).
|
28740224 |
2017 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
OPRM1 rs1799971 and the combined OPRM1/COMT genotype could serve as biomarkers for pain sensitivity.
|
27541715 |
2016 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the overall sample, rs4633 and rs4680 were significantly associated with morphine use, whereas rs4818 was associated with time-averaged pain scores.
|
25963335 |
2016 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In Chinese patients, the incidence of postsurgical pain was significantly higher in variant COMT rs4680 genotypes (P = 0.0007) but not in the Malay or Indian cohorts.
|
27649267 |
2016 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, COMT rs4680 and OPRK rs6473799 polymorphisms seem to be associated with pain sensitivity.
|
27061127 |
2016 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 gene (opioid transporter, C3435T), COMT gene (pain sensitivity, G1947A), and UGT2B7 gene (opioid metabolism, -G840A) were tested.
|
25576257 |
2015 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results indicate that among the genetic SNPs we studied which include those affecting analgesic drug metabolism, transport of analgesic agents across the blood-brain barrier, and their activity at target receptors and ion channels and in the modulation of neurotransmitter pathways, the A118G allele variant of OPRM1 has the most potent influence on pain management of postoperative patients.
|
25794200 |
2015 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results demonstrate that the A118G OPRM1 polymorphism contributes to interindividual variations in the function of neurotransmitters responsive to pain (endogenous opioid and dopamine), as well as their regulation through cognitive-emotional influences in the context of therapeutic expectations, the so-called placebo effect.
|
25308352 |
2015 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several studies have shown that human carriers of the single nucleotide polymorphism of the μ-opioid receptor, OPRM1 A118G, exhibit greater drug and alcohol use, increased sensitivity to pain, and reduced sensitivity to the antinociceptive effects of opiates.
|
25449401 |
2015 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In line with suggestions of a common neural network involved in the processing of physical pain and negative and distressing stimuli, like social rejection as a psychologically harmful event, we examined the influence of the A118G polymorphism on the neural processing of physical and non-physical pain.
|
26019010 |
2015 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic variants in OPRM1, particularly the non-synonymous polymorphism A118G, have been repeatedly associated with the efficacy of treatments for pain and various types of dependence.
|
24201053 |
2014 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association was found between 118A>G and experimental pain
|
25239082 |
2014 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a subpopulation, identifying OPRM1 A118G polymorphism may provide valuable information regarding the individual analgesic doses that are required to achieve satisfactory pain control.
|
25102313 |
2014 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present data indicate that, when controlling for pain intensity and duration, subjective health complaints are associated with a sex - OPRM1 A118G polymorphism interaction in patients with radicular pain.
|
24884878 |
2014 |