|
rs5743708
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The TLR2 Arg753Gln polymorphism might be used as a relevant risk estimate for the development of sepsis.
|
26616674 |
2015 |
|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Sepsis independently associated with HF, increased NOx, peripheral neutrophils, and fibrinogen levels, decreased prothrombin and the presence of the NOS3 (E298D) and NOS2A (exon 22) SNPs.
|
25239655 |
2014 |
|
rs1800625
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The rs1800625 polymorphism is a functional variant, which might be used as a relevant risk estimate for the development of sepsis and multiple organ dysfunction syndrome in patients with major trauma.
|
22827914 |
2012 |
|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Endothelial nitric oxide synthase (eNOS) -786T→C and 894G→T polymorphisms have been associated with eNOS dysfunction, which might further compromise microcirculatory blood flow during sepsis and increase the risk of organ injury.
|
21336191 |
2011 |
|
rs5743708
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We investigated the supposed-2029C>T and 2258G>A TLR2 polymorphisms in 422 critically ill patients of European origin from southern Brazil (295 with sepsis and 127 without sepsis) and reviewed 33 studies on these polymorphisms, conducting a quality assessment with a score system.
|
20578945 |
2010 |
|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The eNOS gene polymorphism at position 894 (G>T, Glu298Asp) resulting in T allele has been studied in the context of vascular diseases, but its role in sepsis has not yet been explored.
|
18827745 |
2009 |
|
rs5743708
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) Arg753Gln and Arg677Trp affect TLR2 responsiveness and may contribute to the course of sepsis, which is associated with substantial morbidity and mortality during intensive care treatment.
|
18249133 |
2008 |
|
rs1061170
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A case-control method (488 septic patients and 527 healthy individuals) was carried out in this study to investigate the genetic relationship between CFH polymorphisms (rs3753394 C/T, rs1065489 G/T and rs1061170 C/T) and susceptibility to sepsis caused by bacterial infections in Chinese Han populations.
|
31525397 |
2020 |
|
rs1129055
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Nevertheless, rs2715267 had no significant association with sepsis susceptibility (P > .05).AA genotype and A allele of CD86 polymorphism rs1129055 might be correlated with decreased sepsis susceptibility in Chinese Han population, but not rs2715267.
|
31651850 |
2019 |
|
rs1800777
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We identified a rare missense variant in CETP (cholesteryl ester transfer protein gene; rs1800777-A) that was associated with significant reductions in HDL-C levels during sepsis.
|
30321485 |
2019 |
|
rs2234237
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The TREM-1 rs2234237 genotype was not significantly associated with sepsis mortality and sepsis disease severity.
|
30832396 |
2019 |
|
rs2249825
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The HMGB1 gene rs2249825 and rs1045411 site SNPs are associated with susceptibility and outcomes of Chinese Han patients with sepsis.
|
30423384 |
2019 |
|
rs231775
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A recent study by our working group revealed that the rs231775 single nucleotide polymorphism (SNP) in the CTLA-4 gene was associated with the survival of patients with sepsis and served as an independent prognostic variable.
|
30634576 |
2019 |
|
rs653765
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Clinical data showed that the rs653765 G→A polymorphism was positively correlated with the development of sepsis, as evidenced by a multiple-center case-control association study with a large sample size, and showed that EGR1 and ADAM10 levels were associated well with the different subtypes of sepsis patients.
|
31387910 |
2019 |
|
rs1129055
|
|
|
0.020 |
GeneticVariation |
BEFREE |
CD86 gene polymorphisms rs1129055 and rs1915087 may increase the risk of sepsis.
|
30343689 |
2018 |
|
rs1800777
|
|
|
0.020 |
GeneticVariation |
BEFREE |
CETP genetic variant rs1800777 (allele A) is associated with abnormally low HDL-C levels and increased risk of AKI during sepsis.
|
30425299 |
2018 |
|
rs1915087
|
|
|
0.020 |
GeneticVariation |
BEFREE |
CD86 gene polymorphisms rs1129055 and rs1915087 may increase the risk of sepsis.
|
30343689 |
2018 |
|
rs2232618
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Significance correlation was observed between rs2232618 and risk of sepsis in Southwest patients (<i>P</i> = 0.002 for the dominant model, <i>P</i> = 0.006 for the recessive model).
|
30479651 |
2018 |
|
rs231775
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, our study provides the first evidence for CTLA-4 rs231775 as a prognostic variable for the survival of patients with sepsis and emphasizes the need for further research to reveal potential functional associations between CTLA-4 and the immune pathophysiology of sepsis.
|
30310101 |
2018 |
|
rs16944
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We conducted a cross-sectional study to genotype 415 septic patients and 205 patients without sepsis for the SNPs -308(G/A) rs1800629 of TNF; +252 (G/A) rs909253 of LTA; -511(A/G) rs16944 and +3953(C/T) rs1143634 of IL1B; and -1082(A/G) rs1800896, -819(C/T) rs1800871 and -592(C/A) rs1800872 of IL10.
|
27592234 |
2016 |
|
rs1800896
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We conducted a cross-sectional study to genotype 415 septic patients and 205 patients without sepsis for the SNPs -308(G/A) rs1800629 of TNF; +252 (G/A) rs909253 of LTA; -511(A/G) rs16944 and +3953(C/T) rs1143634 of IL1B; and -1082(A/G) rs1800896, -819(C/T) rs1800871 and -592(C/A) rs1800872 of IL10.
|
27592234 |
2016 |
|
rs5743551
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Since malaria exerts strong genetic pressure on the human genome, protection from parasitaemia associated with TLR1 rs5743551 may account for the maintenance of an allele associated with poor outcomes in Caucasians with sepsis.
|
26738805 |
2016 |
|
rs1800450
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Variant A allele in MBL2 gene rs1800450 polymorphism might increase the risk of sepsis via decrease the MBL serum level.
|
26823854 |
2015 |
|
rs1915087
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here, we evaluated the association between two CD86 polymorphisms (rs1915087C/T and rs2332096T/G) and susceptibility to pneumonia-induced sepsis.
|
25912130 |
2015 |
|
rs2569190
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, CD14 rs2569190 may act as a prognostic variable for the short-term outcome (30-day survival) in patients with sepsis.
|
26020644 |
2015 |