Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs9722
rs9722
0.010 GeneticVariation BEFREE No association of the rs9722 C >T in the S100B gene and susceptibility to major depression in a Chinese population. 18939940

2008

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants. 19668114

2009

dbSNP: rs6313
rs6313
0.100 GeneticVariation BEFREE Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the HTR2A gene, were studied in 420 patients with MD to investigate the relationship between these genes and suicidal ideation in MD. 19897250

2009

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants. 19668114

2009

dbSNP: rs6295
rs6295
0.050 GeneticVariation BEFREE Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the HTR2A gene, were studied in 420 patients with MD to investigate the relationship between these genes and suicidal ideation in MD. 19897250

2009

dbSNP: rs2230912
rs2230912
0.040 GeneticVariation BEFREE A non-synonymous single nucleotide polymorphism, rs2230912 (P2RX7-E13A, G allele) and a microsatellite marker NBG6 were both previously found to be associated with bipolar disorder (P=0.00071 and 0.008, respectively). rs2230912 has also been found to show association with unipolar depression. 18268501

2009

dbSNP: rs2230912
rs2230912
0.040 GeneticVariation BEFREE We found no allelic or genotypic association between rs2230912 and BPI or Mdd-UP both in the national samples and in the combined European patient sample. 19330776

2009

dbSNP: rs11568817
rs11568817
0.010 GeneticVariation BEFREE A haplotype association study suggested that the rs11568817-rs130058 haplotype of the HTR1B gene is significantly associated with suicidal ideation in MD. 19897250

2009

dbSNP: rs130058
rs130058
0.010 GeneticVariation BEFREE A haplotype association study suggested that the rs11568817-rs130058 haplotype of the HTR1B gene is significantly associated with suicidal ideation in MD. 19897250

2009

dbSNP: rs6691840
rs6691840
0.010 GeneticVariation BEFREE In order to test whether the functional Ser310Ala polymorphism is involved in the development of specific personality traits, and thus to MD, we conducted the first association study on 195 selected healthy Italian individuals. 19221446

2009

dbSNP: rs772335034
rs772335034
0.010 GeneticVariation BEFREE A non-synonymous single nucleotide polymorphism, rs2230912 (P2RX7-E13A, G allele) and a microsatellite marker NBG6 were both previously found to be associated with bipolar disorder (P=0.00071 and 0.008, respectively). rs2230912 has also been found to show association with unipolar depression. 18268501

2009

dbSNP: rs945032
rs945032
0.010 GeneticVariation BEFREE Remarkably, a functional SNP, rs945032, located in the promoter region of the bradykinin receptor B2 gene (BDKRB2) was associated to three disorders (panic disorder, substance abuse, and bipolar disorder), and two additional BDKRB2 SNPs to obsessive-compulsive disorder and major depression, providing evidence for common variants of susceptibility to several related psychiatric disorders. 19086053

2009

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE This effect of rs4680 is similar to its observed influence on response to serotonergic and noradrenergic drug treatments in major depressive disorder. 19520435

2010

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE In the present study, the effect of COMT val158met on response to electroconvulsive therapy (ECT) was analyzed in a sample of 104 Caucasian patients (f = 71, m = 33) with pharmacologically treatment-resistant Major Depression. 19309019

2010

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. 18852698

2010

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder. 20167454

2010

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder. 20674983

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder. 20674983

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. 18852698

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder. 20167454

2010

dbSNP: rs1006737
rs1006737
0.070 GeneticVariation BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression. 19781653

2010

dbSNP: rs1006737
rs1006737
0.070 GeneticVariation BEFREE The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression) and 2286 healthy controls with no symptom of psychopathology. 20226536

2010

dbSNP: rs6311
rs6311
0.050 GeneticVariation BEFREE No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population. 20589614

2010

dbSNP: rs1049353
rs1049353
0.040 GeneticVariation BEFREE We assessed the CB1 receptor gene (CNR1) single nucleotide polymorphism (SNP) rs1049353 (1359 G/A) and the fatty acid amide hydrolase (FAAH) gene rs324420 SNP (cDNA 385C to A) for their associations with MD and/or BD in 83 Caucasian patients with recurrent MD, 134 Caucasian individuals with BD, and 117 Caucasian healthy subjects. 20080186

2010

dbSNP: rs2230912
rs2230912
0.040 GeneticVariation BEFREE The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression) and 2286 healthy controls with no symptom of psychopathology. 20226536

2010