rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004).
|
18853134 |
2008 |
rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
The two markers located within the TCF7L2 gene showed strong associations with T2D (rs7903146, T allele, odd ratio (OR) = 1.76, p = 0.001 and rs12255372, T allele, OR = 1.78, p = 0.002), but did not show significant association with MS.
|
20503258 |
2010 |
rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
The presence of the rs12255372 and rs7903146 TCF7L2 gene variants plays an important role in the development of T2DM among individuals with MS.
|
29971604 |
2018 |
rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
In conclusion, the TCF7L2 rs7903146 polymorphism influences MetS risk, which is augmented by both gender and dietary SFA intake, suggesting novel gene-diet-gender interactions.
|
21543200 |
2012 |
rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS.
|
21749608 |
2011 |
rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms.
|
29193419 |
2018 |
rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were associated with atherogenic dyslipidemia in carriers of the minor T allele at the TCF7L2 rs7903146 SNP and may predispose them to MetS, diabetes, and cardiovascular disease.
|
19141698 |
2009 |
rs3764261
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Our data support the notion that the consumption of a Mediterranean diet may play a contributing role in triggering lipid metabolism by interacting with the rs3764261 SNP at CETP gene locus in MetS patients.
|
28057378 |
2018 |
rs3764261
|
|
|
0.830 |
GeneticVariation |
BEFREE |
(3) The rs1800775 polymorphism was associated with high fasting blood glucose levels and low high density lipoprotein cholesterol (HDL-C); rs3764261 and rs12149545 polymorphisms were associated with all components of MS except high blood pressure; rs711752 and rs708272 polymorphisms were associated with low HDL-C (all <i>p</i> < 0.05).
|
28629169 |
2017 |
rs3764261
|
|
|
0.830 |
GeneticVariation |
BEFREE |
No significant interactions were found between rs3764261 and macronutrient intakes in association with MetS or its components.
|
29942448 |
2018 |
rs780094
|
|
|
0.830 |
GeneticVariation |
GWASCAT |
Multiple genotype-phenotype association study reveals intronic variant pair on SIDT2 associated with metabolic syndrome in a Korean population.
|
30382898 |
2018 |
rs780094
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Our results support that rs780094 and rs1260326 functional variants of the GCKR gene are inversely associated with serum triglycerides and fasting plasma glucose levels, as it was already reported for diabetic and metabolic syndrome patients in some other populations.
|
21114848 |
2010 |
rs780094
|
|
|
0.830 |
GeneticVariation |
BEFREE |
The GCKR rs780094 polymorphism is associated with low HDL-C levels and MetS incidence in Taiwanese adolescents.
|
26799416 |
2016 |
rs780094
|
|
|
0.830 |
GeneticVariation |
GWASCAT |
New Common and Rare Variants Influencing Metabolic Syndrome and Its Individual Components in a Korean Population.
|
29632305 |
2018 |
rs780094
|
|
|
0.830 |
GeneticVariation |
BEFREE |
The intragenic rs1244979, rs2815752 in NEGR1 gene, and rs780094 in GCKR gene were genotyped and CNVs were determined by droplet digital polymerase chain reaction (ddPCR) in PCOS patients (n = 153) and controls without metabolic syndrome (n = 142).
|
27878529 |
2017 |
rs560887
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome.
|
19669124 |
2009 |
rs560887
|
|
|
0.820 |
GeneticVariation |
BEFREE |
No association was detected between rs7612463 (UBE2E2) and rs560887 (G6PC2) SNPs and MetS increased risk.
|
28919193 |
2017 |
rs964184
|
|
|
0.810 |
GeneticVariation |
BEFREE |
A previously known lipid locus, APOA1/C3/A4/A5 gene cluster region (SNP rs964184), was associated with MetS in all 4 study samples (P=7.23×10(-9) in meta-analysis).
|
22399527 |
2012 |
rs102275
|
|
|
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association study of the metabolic syndrome in Indian Asian men.
|
20694148 |
2010 |
rs102275
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study of the metabolic syndrome in Indian Asian men.
|
20694148 |
2010 |
rs2075291
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The chi(2) test and subsequent multivariate logistic regression analysis with adjustment for age, sex and smoking status found that the-3A-->G and 553G-->T (Gly185Cys) polymorphisms of APOA5, the 2052T-->C (Val653Val) and 1866C-->T (Asn591Asn) polymorphisms of LDLR, the 13989A-->G (Ile118Val) polymorphism of CYP3A4 and the 1014T-->A polymorphism of C1QTNF5 were significantly (false discovery rate <0.05) associated with the prevalence of metabolic syndrome, with the variant alleles of APOA5 and C1QTNF5 representing risk factors for and those of LDLR and CYP3A4 being protective against this condition.
|
17766366 |
2008 |
rs2075291
|
|
|
0.720 |
GeneticVariation |
BEFREE |
It seems that APOA5 rs2075291 could play an important role in triglyceride and HDL-C level in metabolic syndrome affected, while the association of APOA5 rs662799 polymorphism is still under debate.
|
26702748 |
2016 |
rs651821
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Even after adjustment for MetS status, reduced abundances of Actinobacteria and <i>Bifidobacterium</i> were significantly linked to the minor allele at the <i>APOA5</i> SNP rs651821.
|
27053630 |
2017 |
rs651821
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Notably, by an integrated analysis of the genotypes and the serum levels of APOA5, BUD13 and triglyceride, we observed that BUD13 was another potential mediator, besides APOA5, of the association between rs651821 and serum triglyceride. rs671 (ALDH2), an east Asian-specific common variant, was found to be associated with MetS (P<sub>combined</sub> = 9.7 × 10<sup>-22</sup> ) in Han Chinese.
|
28371326 |
2017 |
rs16944558
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Our data showed an association of MetS at the genome-wide significance level (<i>P</i> < 8.6 x 10<sup>-8</sup>) with two SNPs, including the rs662799 SNP in the apolipoprotein A5 (<i>APOA5</i>) gene and the rs16944558 SNP in the collectin subfamily member 12 (<i>COLEC12</i>) gene.
|
29212154 |
2017 |