|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast-ovarian cancer kindreds.
|
9407954 |
1997 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast-ovarian cancer kindreds.
|
9407954 |
1997 |
|
rs63750447
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a search for germline mutations in the DNA mismatch repair genes hMSH2 and hMLH1 in Chinese patients with colorectal cancer we identified a novel missense mutation (V384D) in exon 12 of the hMLH1 gene in 4 out of 26 individuals.
|
9526167 |
1998 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among the 1087 first-degree relatives, there were 23 cases of colorectal cancer; 3 of 100 relatives of probands with the I1307K allele (3.0%) had a history of colorectal cancer versus 20 of 987 relatives of probands without the I1307K allele (2.1%; relative risk, 1.48; 95% confidence interval, 0.45-4.88; P = 0.462).
|
9679945 |
1998 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among the 1087 first-degree relatives, there were 23 cases of colorectal cancer; 3 of 100 relatives of probands with the I1307K allele (3.0%) had a history of colorectal cancer versus 20 of 987 relatives of probands without the I1307K allele (2.1%; relative risk, 1.48; 95% confidence interval, 0.45-4.88; P = 0.462).
|
9679945 |
1998 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data show that the I1307K variant is rare in the Norwegian population and should not be viewed as a candidate for susceptibility testing for colorectal cancer.
|
9679946 |
1998 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data show that the I1307K variant is rare in the Norwegian population and should not be viewed as a candidate for susceptibility testing for colorectal cancer.
|
9679946 |
1998 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interestingly, the I1307K APC polymorphism, associated with an increased risk of colorectal cancer, is also present in this family.
|
9831355 |
1998 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interestingly, the I1307K APC polymorphism, associated with an increased risk of colorectal cancer, is also present in this family.
|
9831355 |
1998 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis.
|
9869602 |
1999 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis.
|
9869602 |
1999 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings support the hypothesis that the I1307K mutation is unique to the Ashkenazi Jews, contributes to tumor predisposition in colorectal cancer, and is unrelated to mismatch repair deficiency.
|
9869603 |
1999 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings support the hypothesis that the I1307K mutation is unique to the Ashkenazi Jews, contributes to tumor predisposition in colorectal cancer, and is unrelated to mismatch repair deficiency.
|
9869603 |
1999 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the APC I1307K variant leads to increased adenoma formation and directly contributes to 3%-4% of all Ashkenazi Jewish colorectal cancer.
|
9973276 |
1999 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the APC I1307K variant leads to increased adenoma formation and directly contributes to 3%-4% of all Ashkenazi Jewish colorectal cancer.
|
9973276 |
1999 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An adenomatous polyposis coli (APC) gene variant (I1307K allele), which was recently reported in 1 in 17 Ashkenazi Jewish persons, may double the risk for colorectal cancer in that population.
|
10343885 |
1999 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An adenomatous polyposis coli (APC) gene variant (I1307K allele), which was recently reported in 1 in 17 Ashkenazi Jewish persons, may double the risk for colorectal cancer in that population.
|
10343885 |
1999 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The 677C > T mutation in 5,10-methylenetetrahydrofolate reductase and colorectal cancer risk.
|
10464674 |
1999 |
|
rs1805087
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we examined the relationship of a polymorphism (2756A-->G, asp-->gly) in the gene (MTR) for methionine synthase, another important enzyme in the same folate/methionine/homocyst(e)ine metabolic pathway, with risk of colorectal cancer among 356 cases and 476 cancer-free controls.
|
10498402 |
1999 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K polymorphism in APC has been found to predispose to colorectal cancer in Ashkenazi Jews, and has recently been associated with an increased risk for breast cancer in the same population.
|
10555757 |
1999 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K polymorphism in APC has been found to predispose to colorectal cancer in Ashkenazi Jews, and has recently been associated with an increased risk for breast cancer in the same population.
|
10555757 |
1999 |
|
rs1801166
|
|
|
0.080 |
GeneticVariation |
BEFREE |
This finding suggests that E1317Q is unlikely to be associated with anything more than a moderate increase in risk of colorectal cancer.
|
10737725 |
2000 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine the carrier rate of the I1307K mutation in Ashkenazi Jewish patients with a history of colorectal polyps but without colorectal cancer and to compare phenotypic characteristics and family history of carriers vs noncarriers.
|
10938175 |
2000 |
|
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine the carrier rate of the I1307K mutation in Ashkenazi Jewish patients with a history of colorectal polyps but without colorectal cancer and to compare phenotypic characteristics and family history of carriers vs noncarriers.
|
10938175 |
2000 |
|
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K allele of the APC gene has been shown to confer a modestly elevated risk of colorectal cancer in the Ashkenazi Jewish population (relative risk, 1.5-1.7).
|
11159880 |
2001 |