|
rs10012
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotypes of rs1056827 and rs10012 or rs1056827 and rs1056836 revealed an association with colorectal cancer which was significantly stronger in the homozygous carriers.
|
20701755 |
2010 |
|
rs10012
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis indicates that CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly polymorphisms do not support an association with colorectal cancer, and further studies are needed to investigate the association.
|
25115775 |
2014 |
|
rs10090154
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two correlated SNPs--rs10090154 and rs4242382--in Region 1 of chromosome 8q24, a prostate cancer susceptibility region, demonstrated statistically significant associations with colorectal cancer risk.
|
23935004 |
2014 |
|
rs10165970
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Study distribution by tumor was as follows: breast cancer (n=15), prostate cancer (n=3), pancreatic cancer (n=2), non-Hodgkin's lymphoma (n=2), glioma (n=1), chronic lymphocytic leukemia (n=1), colorectal cancer (n=1), non-small cell lung cancer (n=1) and ovarian cancer (n=1).We identified 10 single nucleotide polymorphisms (SNPs) significantly associated with cancer risk: NPAS2 rs10165970 (mixed and breast cancer shiftworkers), rs895520 (mixed), rs17024869 (breast) and rs7581886 (breast); CLOCK rs3749474 (breast) and rs11943456 (breast); RORA rs7164773 (breast and breast cancer postmenopausal), rs10519097 (breast); RORB rs7867494 (breast cancer postmenopausal), PER3 rs1012477 (breast cancer subgroups) and assessed the level of quality evidence to be intermediate.
|
28177907 |
2017 |
|
rs10318
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Common genetic variants (rs4779584 and rs10318) at 15q13.3 contributes to colorectal adenoma and colorectal cancer susceptibility: evidence based on 22 studies.
|
25475391 |
2015 |
|
rs10380
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we have assessed the association of six polymorphisms and relative haplotypes in the MTHFR gene (rs1801133 and rs1801131) and in the MTRR gene (rs1801394, rs1532268, rs162036, and rs10380) with the risk for colorectal cancer in 666 patients and 1377 controls from the Czech Republic.
|
21211571 |
2011 |
|
rs10411210
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The present results suggest that the genetic variants of the CDKN1A (rs1321311) and RHPN2 (rs10411210) genes can be used as prognostic biomarkers for patients with surgically resected colorectal cancer.
|
25799222 |
2015 |
|
rs10411210
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Collectively, our analysis further highlights significant association between rs10411210 polymorphism and colorectal cancer.
|
26349980 |
2015 |
|
rs1042028
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Lack of association of SULT1A1 R213H polymorphism with colorectal cancer: a meta-analysis.
|
21695180 |
2011 |
|
rs1042028
|
|
|
0.020 |
GeneticVariation |
BEFREE |
From this study, we conclude that the SULT1A1 R213H polymorphism is not linked with colorectal cancer in this elderly Australian population.
|
12165038 |
2002 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the TP53 R72P polymorphism may contribute to the etiology of colorectal cancer in the Chinese population, particularly among alcohol consumers.
|
17599946 |
2007 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, heterozygosity and mutant homozygosity as well as the combination of both TP53 Arg72Pro and CDH1 rs16260 polymorphisms are responsible to increase the risk of colorectal cancer development in Bangladeshi population.
|
28554075 |
2017 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We did not identify an association between TP53 rs1042522 and colorectal cancer.
|
20615891 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibility risk in Malaysian population.
|
22393962 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TP53 Arg 72Pro and MDM2 SNP309 polymorphisms and colorectal cancer risk: a west Algerian population study.
|
25537146 |
2015 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between p53 Arg72Pro polymorphism and colorectal cancer risk in Asian population: a meta-analysis.
|
30316510 |
2018 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer.
|
18988302 |
2008 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg462Gln in RNASEL are associated with the age of disease onset of colorectal cancer in Lynch syndrome patients.
|
17224235 |
2007 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis.
|
29872345 |
2018 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study.
|
21051533 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in an ethnic Kashmiri population.
|
20449797 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use.
|
17622940 |
2007 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among 442 colorectal cancer cases and 904 controls, we observed no significant overall association between p53 Arg72Pro genotype and colorectal cancer (multivariate OR = 1.14, 95% CI = 0.90-1.45).
|
16721787 |
2006 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association between the TP53 Arg72Pro polymorphism and colorectal cancer: An updated meta-analysis based on 32 studies.
|
27901479 |
2017 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Age of diagnosis of colorectal cancer in HNPCC patients is more complex than that predicted by R72P polymorphism in TP53.
|
16353134 |
2006 |