|
rs4444235
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Genome-wide association studies have identified rs4444235 at BMP4 as a new colorectal cancer (CRC) and colorectal adenoma (CRA) susceptibility locus in populations of European descent.
|
25647270 |
2015 |
|
rs4444235
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The SNP rs4444235 at 14q22.2 interacted with regular exercise in colorectal cancer (p<sub>case-only</sub> = 2.4 × 10<sup>- 3</sup>, p<sub>case-control</sub> = 1.5 × 10<sup>- 3</sup>).
|
31849324 |
2019 |
|
rs4444235
|
|
|
0.050 |
GeneticVariation |
BEFREE |
BMP4 rs4444235 is a candidate susceptibility allele that has been associated with an increased risk of colore</span>ctal cancer.
|
22170598 |
2012 |
|
rs4444235
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We observed an association between the low colorectal cancer risk allele (A) for rs10795668 at 10p14 and increased expression of ATP5C1 (q = 0.024) and between the colorectal cancer high risk allele (C) for rs4444235 at 14q22.2 and increased expression of DLGAP5 (q = 0.041), both in tumor samples.
|
22363440 |
2012 |
|
rs4444235
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The common variant rs4444235 near BMP4 confers genetic susceptibility of colorectal cancer: an updated meta-analysis based on a comprehensive statistical strategy.
|
24932582 |
2014 |
|
rs16892766
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of this study was to test 11 loci, reported to be associated with an increased or decreased risk of colorectal cancer: 8q23.3 (rs16892766), 8q24.21 (rs6983267), 9p24 (rs719725), 10p14 (rs10795668), 11q23.1 (rs3802842), 14q22.2 (rs4444235), 15q13.3 (rs4779584), 16q22.1 (rs9929218), 18q21.1 (rs4939827), 19q13.1 (rs10411210) and 20p12.3 (rs961253), in a Swedish-based cohort.
|
20648012 |
2010 |
|
rs16892766
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Analyzing large-scale samples confirms the association between rs16892766 polymorphism and colorectal cancer susceptibility.
|
25609216 |
2015 |
|
rs4779584
|
|
|
0.020 |
GeneticVariation |
BEFREE |
GREM1-SCG5 rs4779584 polymorphisms may increase the risk of developing colorectal cancer.
|
24586997 |
2014 |
|
rs4779584
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Common genetic variants (rs4779584 and rs10318) at 15q13.3 contributes to colorectal adenoma and colorectal cancer susceptibility: evidence based on 22 studies.
|
25475391 |
2015 |
|
rs6687758
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggest that SNP rs6687758 at 1q41 may interact with alcohol consumption in the etiology of colorectal cancer.
|
29464080 |
2018 |
|
rs6687758
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In genome-wide association studies (GWASs) of colorectal cancer, we have identified two genomic regions in which pairs of tagging-single nucleotide polymorphisms (tagSNPs) are associated with disease; these comprise chromosomes 1q41 (rs6691170, rs6687758) and 12q13.13 (rs7163702, rs11169552).
|
22076443 |
2012 |
|
rs719725
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Furthermore, NIRF is immediately adjacent to the single nucleotide polymorphism rs719725, which is reportedly associated with the risk of colorectal cancer.
|
21952639 |
2011 |
|
rs719725
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SNP rs719725 was statistically significantly associated with risk of colorectal cancer in WHI (OR per A allele 1.19; 95% CI, 1.01-1.40; P(trend) = 0.04), marginally associated with adenoma risk in PLCO (OR per A allele 1.11; 95% CI, 0.99-1.25; P(trend) = 0.07), and not associated in DALS and MinnCCS.
|
20978172 |
2010 |
|
rs10090154
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two correlated SNPs--rs10090154 and rs4242382--in Region 1 of chromosome 8q24, a prostate cancer susceptibility region, demonstrated statistically significant associations with colorectal cancer risk.
|
23935004 |
2014 |
|
rs1088967
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The IL-17A rs2275913 (G197A), IL-17F rs763780 (T7488C), IL-23R rs11209026 and IL-23R rs1088967 SNPs were detected in 202 patients with colorectal cancer and 203 healthy age/sex matched controls by PCR-RFLP method.
|
25680555 |
2015 |
|
rs1194338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified that a single nucleotide polymorphism (SNP) rs1194338 was significantly associated with the decreased colorectal cancer risk with an odds ratio (OR) of 0.70 [95% confidence interval (CI) = 0.49-0.99] in the combined stage.
|
29190941 |
2017 |
|
rs12413624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotype "A/T" of rs12413624 in PRLHR gene was associated with a decreased risk of colorectal cancer in allele model analysis [odds ratio (OR) = 0.81; 95% confidence interval (CI) = 0.68-0.97; p = 0.018] and log-additive model analysis (OR = 0.81; 95% CI = 0.66-0.98; p = 0.032).
|
26302849 |
2015 |
|
rs1321311
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present results suggest that the genetic variants of the CDKN1A (rs1321311) and RHPN2 (rs10411210) genes can be used as prognostic biomarkers for patients with surgically resected colorectal cancer.
|
25799222 |
2015 |
|
rs1535989
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An additional variant associated with advanced adenomas, rs1535989 [minor allele frequency, 0.11; OR, 2.09; 95% confidence interval (CI), 1.50-2.91], also predicted colorectal cancer development in a validation analysis (P = 0.019) using a series of adenoma cases or colorectal cancer (CORGI study) and 3 sets of colorectal cancer cases and controls (Scotland, VQ58, and Australia; N = 9,211).
|
24084763 |
2013 |
|
rs180040
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The previous published data on the association between CYP1A2*F (rs762551), CYP1B1 Leu432Val (rs1056836), Asn453Ser (rs180040), and Arg48Gly (rs10012) polymorphisms and colorectal cancer risk remained controversial.
|
25115775 |
2014 |
|
rs1924966
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two novel variants, rs1924966 and rs115797771, were associated with ESCC risk (P = 1.37 × 10(-10) and P = 2.32 × 10(-10), respectively) and were also associated with risk of gastric cardia cancer (P = 0.0003 and P = 0.0018, respectively) but not gastric cancer and colorectal cancer.
|
26315552 |
2015 |
|
rs2555639
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism rs2555639 in 15-PGDH and colorectal cancer metastasis.
|
31646799 |
2020 |
|
rs2808630
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CRP rs2808630 polymorphism was related to the decreased risk of colorectal cancer, but not +1444C/T polymorphism.
|
31141720 |
2019 |
|
rs2965667
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Aspirin and/or NSAID use was associated with a lower risk of colorectal cancer among individuals with rs2965667-TT genotype (prevalence, 28% vs 38%; OR, 0.66 [95% CI, 0.61-0.70]; P = 7.7 × 10(-33)) but with a higher risk among those with rare (4%) TA or AA genotypes (prevalence, 35% vs 29%; OR, 1.89 [95% CI, 1.27-2.81]; P = .002).
|
25781442 |
2015 |
|
rs4242382
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two correlated SNPs--rs10090154 and rs4242382--in Region 1 of chromosome 8q24, a prostate cancer susceptibility region, demonstrated statistically significant associations with colorectal cancer risk.
|
23935004 |
2014 |