PDLIM5, PDZ and LIM domain 5, 10611

N. diseases: 148; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease PSYGENET These results suggest that PDLIM5 might play a role in genetic susceptibility to schizophrenia. 16213469 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE These results suggest that PDLIM5 might play a role in genetic susceptibility to schizophrenia. 16213469 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE These findings suggested the role of LIM in the pathophysiology of bipolar disorder and schizophrenia. 16044170 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE We also found the altered expressions of HSPF1 in LCLs from Caucasian patients with bipolar II disorder (P=0.011) and LIM in those from patients with schizophrenia (P = 0.001). 15362566 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 AlteredExpression disease LHGDN We also found the altered expressions of HSPF1 in LCLs from Caucasian patients with bipolar II disorder (P=0.011) and LIM in those from patients with schizophrenia (P = 0.001). 15362566 2004
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE The PDZ and LIM domain 5 (PDLIM5) gene may play a role in alcohol dependence (AD), bipolar disorder, and major depressive disorder; however, no study has identified shared genetic variants within PDLIM5 gene among AD, type 2 diabetes (T2D), and hypertension. 27693979 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease PSYGENET The PDLIM5 (PDZ and LIM domain 5) gene has been genetically associated with mood disorders; it's expression is upregulated in the postmortem brains of patients with bipolar disorder and downregulated in the peripheral lymphocytes of patients with major depression. 23593136 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease PSYGENET These results support the hypothesis of a protective effect for the G allele of rs2433320 in the PDLIM5 gene in recurrent MDD. 18197271 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE These results support the hypothesis of a protective effect for the G allele of rs2433320 in the PDLIM5 gene in recurrent MDD. 18197271 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease PSYGENET Then, we genotyped three single nucleotide polymorphic markers of LIM gene, which were reported to be associated with bipolar disorder in patients with major depression and control subjects (n=130, each), but there were no associations between these SNPs and major depression. 16595163 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE Then, we genotyped three single nucleotide polymorphic markers of LIM gene, which were reported to be associated with bipolar disorder in patients with major depression and control subjects (n=130, each), but there were no associations between these SNPs and major depression. 16595163 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease PSYGENET We previously reported that expression level of LIM (ENH, PDLIM5) was significantly and commonly increased in the brains of patients with bipolar disorder, schizophrenia, and major depression. 16044170 2005
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease BEFREE We previously reported that expression level of LIM (ENH, PDLIM5) was significantly and commonly increased in the brains of patients with bipolar disorder, schizophrenia, and major depression. 16044170 2005
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 GeneticVariation disease BEFREE The PDZ and LIM domain 5 (PDLIM5) gene may play a role in alcohol dependence (AD), bipolar disorder, and major depressive disorder; however, no study has identified shared genetic variants within PDLIM5 gene among AD, type 2 diabetes (T2D), and hypertension. 27693979 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 Biomarker disease PSYGENET The PDLIM5 (PDZ and LIM domain 5) gene has been genetically associated with mood disorders; it's expression is upregulated in the postmortem brains of patients with bipolar disorder and downregulated in the peripheral lymphocytes of patients with major depression. 23593136 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 Biomarker disease PSYGENET A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder. 18197271 2008
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 Biomarker disease PSYGENET Then, we genotyped three single nucleotide polymorphic markers of LIM gene, which were reported to be associated with bipolar disorder in patients with major depression and control subjects (n=130, each), but there were no associations between these SNPs and major depression. 16595163 2006
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 GeneticVariation disease BEFREE Then, we genotyped three single nucleotide polymorphic markers of LIM gene, which were reported to be associated with bipolar disorder in patients with major depression and control subjects (n=130, each), but there were no associations between these SNPs and major depression. 16595163 2006
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 Biomarker disease BEFREE We previously reported that expression level of LIM (ENH, PDLIM5) was significantly and commonly increased in the brains of patients with bipolar disorder, schizophrenia, and major depression. 16044170 2005
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.330 Biomarker disease PSYGENET We previously reported that expression level of LIM (ENH, PDLIM5) was significantly and commonly increased in the brains of patients with bipolar disorder, schizophrenia, and major depression. 16044170 2005
CUI: C0221765
Disease: Chronic schizophrenia
Chronic schizophrenia 		0.310 AlteredExpression disease BEFREE There was no difference in the PDLIM5 mRNA levels between chronic schizophrenic patients with antipsychotic medication and their controls. 17287082 2007
CUI: C0019193
Disease: Hepatitis, Toxic
Hepatitis, Toxic 		0.300 Biomarker disease CTD_human Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model. 25231249 2015
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.300 Biomarker phenotype CTD_human Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model. 25231249 2015
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced 		0.300 Biomarker disease CTD_human Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model. 25231249 2015
CUI: C3658290
Disease: Drug-Induced Acute Liver Injury
Drug-Induced Acute Liver Injury 		0.300 Biomarker disease CTD_human Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model. 25231249 2015