|
Chemical and Drug Induced Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
|
25231249 |
2015 |
|
Chemically-Induced Liver Toxicity
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
|
25231249 |
2015 |
|
Myocardial Ischemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study.
|
16214533 |
2005 |
|
Cardiomyopathy, Dilated
|
0.220 |
Biomarker
|
group |
BEFREE |
A PDLIM3 or PDLIM5 deficiency in mice leads to dilated cardiomyopathy.
|
31424159 |
2019 |
|
Cardiomyopathy, Dilated
|
0.220 |
GeneticVariation
|
group |
BEFREE |
It was demonstrated by both assays that the D626N mutation of Cypher/ZASP increased the affinity of the LIM domain for protein kinase C, suggesting a novel biochemical mechanism of the pathogenesis of dilated cardiomyopathy.
|
14660611 |
2004 |
|
Cardiomyopathy, Dilated
|
0.220 |
Biomarker
|
group |
MGD |
|
|
|
|
Prostate carcinoma
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
|
29892016 |
2018 |
|
Malignant neoplasm of prostate
|
0.130 |
Biomarker
|
disease |
BEFREE |
Finally, we found PDLIM5 plays a crucial role in regulating malignant tumor cell proliferation, invasion and migration by binding to AMPK and affecting its activation and degradation, and may therefore prove to be a potential oncogenic gene in the development and progression of PCa.
|
29228678 |
2017 |
|
Prostate carcinoma
|
0.130 |
Biomarker
|
disease |
BEFREE |
Finally, we found PDLIM5 plays a crucial role in regulating malignant tumor cell proliferation, invasion and migration by binding to AMPK and affecting its activation and degradation, and may therefore prove to be a potential oncogenic gene in the development and progression of PCa.
|
29228678 |
2017 |
|
Malignant neoplasm of prostate
|
0.130 |
AlteredExpression
|
disease |
BEFREE |
By staining prostate cancer tumor sections, elevated LIM kinase 1 (LIMK1) expression and increased phosphorylation of its substrate Cofilin were found to be associated with poor outcome and reduced survival in patients with nonmetastatic prostate cancer.
|
25344584 |
2015 |
|
Prostate carcinoma
|
0.130 |
AlteredExpression
|
disease |
BEFREE |
By staining prostate cancer tumor sections, elevated LIM kinase 1 (LIMK1) expression and increased phosphorylation of its substrate Cofilin were found to be associated with poor outcome and reduced survival in patients with nonmetastatic prostate cancer.
|
25344584 |
2015 |
|
Malignant neoplasm of prostate
|
0.130 |
GeneticVariation
|
disease |
GWASDB |
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
|
19767753 |
2009 |
|
Prostate carcinoma
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
|
19767753 |
2009 |
|
Malignant neoplasm of prostate
|
0.130 |
Biomarker
|
disease |
BEFREE |
Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancer.
|
17559677 |
2007 |
|
Prostate carcinoma
|
0.130 |
Biomarker
|
disease |
BEFREE |
Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancer.
|
17559677 |
2007 |
|
Nasopharyngeal carcinoma
|
0.110 |
Biomarker
|
disease |
BEFREE |
This study aims to assess the role of miR-506 working in tandem with LIM Homeobox 2 (LHX2) in EMT and metastasis through the Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma (NPC).
|
30791932 |
2019 |
|
Nasopharyngeal carcinoma
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
|
20512145 |
2010 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The LIM kinase isoforms LIMK1 and LIMK2 (LIMK1/2) play important roles in cell polarization, migration, and invasion and are markedly upregulated in GBM and many other infiltrative cancers.
|
31641031 |
2020 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LIM domains-containing protein 1 (LIMD1) is a tumor suppressor protein downregulated in numerous solid malignancies.
|
30854077 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We also analyzed the mRNA levels of target genes that candidate miRNAs might regulate in patient tissues. miR-214-3p was highly expressed in tissues and exosomes derived from EOC with high malignancy and also found to regulate the expression of LIM homeobox domain 6 (LHX6) mRNA.
|
31810245 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LIM kinases modulate multiple aspects of cancer development, including cell proliferation and survival.
|
30006972 |
2019 |
|
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.
|
31649266 |
2019 |
|
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
As the mechanisms of LIMK-associated tumorigenesis are still unclear, we analyzed the tumorigenic functions of LIM kinase 2 (LIMK2) in human bladder cancer (BC) and explored whether the newly identified LIMK2 3´-UTR SNP rs2073859 (G-to-A allele) is correlated with clinical features.
|
30006972 |
2019 |
|
Plexiform leiomyoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.
|
31649266 |
2019 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Four-and-a-half LIM protein2 (FHL2) is a member of the LIM-only protein family, which plays a critical role in tumorigenesis.
|
29321665 |
2018 |