|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Recently, a mouse model of asthma showed that gob-5 is involved in the pathogenesis of asthma.
|
15318163 |
2004 |
|
Cystic Fibrosis
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Our study hints at the therapeutic potential of the selective activation of TMEM16A by the CLCA1 VWA domain in loss-of-function chloride channelopathies such as cystic fibrosis.
|
28420732 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.030 |
GeneticVariation
|
disease |
LHGDN |
CLCA1 gene polymorphisms in chronic obstructive pulmonary disease.
|
14985398 |
2004 |
|
Hepatic Encephalopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genetic analyses showed that glutaminase TACC and CACC haplotypes were linked to the risk for overt hepatic encephalopathy.
|
20820037 |
2010 |
|
Hypertriglyceridemia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Analysis of the two major SNPs from APOA5 [c.56C > G, c.-3A > G] and from APOC3 [c.102C > T, c.340C > G] using THESIAS has identified two major haplotypes relative to the most common CACC haplotype showing very strong association with hypertriglyceridaemia, CGTG and GATC (odds ratio 7.45 and 5.26).
|
16125709 |
2006 |
|
Channelopathies
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study hints at the therapeutic potential of the selective activation of TMEM16A by the CLCA1 VWA domain in loss-of-function chloride channelopathies such as cystic fibrosis.
|
28420732 |
2017 |
|
Meconium ileus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to investigate whether the p.S357N variant in CLCA1, the human orthologue of Clca3, acts as a modifier gene in a cohort of 682 European patients with cystic fibrosis (CF)-99 patients with meconium ileus.
|
20179644 |
2010 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 3-gene signature of periostin, chloride channel accessory 1 (CLCA1), and Serpin β2 (SERPINB2) in airway epithelial brushings is used to classify asthma into TH2-high and TH2-low endotypes.
|
24075231 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Oxidant stress stimulates Ca2+-activated chloride channels in the apical activated membrane of cultured nonciliated human nasal epithelial cells.
|
16148052 |
2005 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Potential anti-mRNA drugs in asthma and other allergic disorders may be targeted to cell surface receptors (adenosine A1 receptor, high-affinity receptor Fc-epsilon RI-alpha, cytokine receptors), adhesion molecules and ligands (ICAM-1, VLA-4), ion channels (calcium-dependent chloride channel-1), cytokines and related factors (IL-4, IL-5, IL-13, SCF, TNF-alpha, TGF-beta1), intracellular signal transduction molecules, such as tyrosine-protein kinases (Syk, Lyn, Btk), serine/ threonine-protein kinases (p38 alpha MAPkinase, Raf-1), non-kinase signaling proteins (RasGRP4), and transcription factors involved in Th2 differentiation and allergic inflammation (STAT-6, GATA-3, NF-kappaB).
|
16364194 |
2006 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results indicated that gob-5 may play a critical role in murine asthma, and its human counterpart hCLCA1 is therefore a potential target for asthma therapy.
|
11296262 |
2001 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma.
|
30952704 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that CaCC1 plays a direct role in mucus production and differentiation in goblet cells and may contribute to the pathogenesis of asthma through its mucus-inducing activity.
|
11956057 |
2002 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human hCLCA1 and murine mCLCA3 (chloride channels, calcium-activated) have recently been identified as promising therapeutic targets in asthma.
|
15879574 |
2005 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, a mouse model of asthma showed that gob-5 is involved in the pathogenesis of asthma.
|
15318163 |
2004 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that adenosine cooperates with inflammatory cytokines to stimulate mucin production in the asthmatic airway and supports the use of A1, CLCA1, and EGFR inhibitors in the treatment of asthma.
|
15345696 |
2004 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
This suggests that CLCA1 has similar important functions in CF-related intestinal obstruction in humans as in Cftr-/- mice.
|
20179644 |
2010 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
LHGDN |
The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.
|
15490240 |
2004 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
The results suggest that pCLCA1 shares essential characteristics of hCLCA1, supporting the pig model as a promising tool for studying the modulating role of pCLCA1 in the complex pathology of CF.
|
19755716 |
2009 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
These findings suggest that human CLCA1 mediates a Ca2+-activated Cl- conductance in the human intestine and make it an interesting candidate as a modulating factor in the pathogenesis of cystic fibrosis.
|
9828122 |
1998 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
They warrant evaluation of CLCA1 blockers as adjunctive therapy in this condition and describe a simple model to evaluate therapeutic interventions for steroid resistant mucus, a common condition in patients with chronic lung disease like asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
|
31333624 |
2019 |
|
Colorectal Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
We finally established a five-gene signature (kinesin family member 15, N-acetyltransferase 2, glutathione peroxidase 3, secretogranin II, and chloride channel accessory 1) with prognostic value in CRC by step multivariate Cox regression analysis.
|
30132881 |
2019 |
|
Colorectal Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Thus, CEACAM7, SLC4A4, GCG and CLCA1 may be prognostic markers or therapeutic targets of CRC.
|
31612015 |
2019 |
|
Colorectal Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
The upregulation of karyopherin α 2 (KPNA2) and chromosome segregation 1‑like (CSE1L) in colorectal carcinoma, in addition to downregulation of chloride channel accessory 1 (CLCA1), fatty acid binding protein 1 (FABP1), sodium channel, voltage gated, type VII α subunit (SCN7A) and solute carrier family 26 (anion exchanger), member 3 (SLC26A3) was confirmed.
|
27121919 |
2016 |
|
Colorectal Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Our results suggest that CLCA1 could specify a new tumor suppressor and that, as in breast cancer, CLCA2 may function as a tumor suppressor in colorectal cancer.
|
11445004 |
2001 |