|
airway disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In addition to its ability to upregulate cytokine expression which explains previous observations in the Clca1-deficient S. aureus pneumonia mouse model, modulation of BPIFA1 expression expands the role of CLCA1 in airway disease to involvement in more complex downstream pathways, possibly including liquid homeostasis, airway protection, and antimicrobial defense.
|
29610986 |
2018 |
|
airway disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma.
|
30952704 |
2019 |
|
airway disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
CLCA1 and TMEM16A: the link towards a potential cure for airway diseases.
|
26296094 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 3-gene signature of periostin, chloride channel accessory 1 (CLCA1), and Serpin β2 (SERPINB2) in airway epithelial brushings is used to classify asthma into TH2-high and TH2-low endotypes.
|
24075231 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Oxidant stress stimulates Ca2+-activated chloride channels in the apical activated membrane of cultured nonciliated human nasal epithelial cells.
|
16148052 |
2005 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Potential anti-mRNA drugs in asthma and other allergic disorders may be targeted to cell surface receptors (adenosine A1 receptor, high-affinity receptor Fc-epsilon RI-alpha, cytokine receptors), adhesion molecules and ligands (ICAM-1, VLA-4), ion channels (calcium-dependent chloride channel-1), cytokines and related factors (IL-4, IL-5, IL-13, SCF, TNF-alpha, TGF-beta1), intracellular signal transduction molecules, such as tyrosine-protein kinases (Syk, Lyn, Btk), serine/ threonine-protein kinases (p38 alpha MAPkinase, Raf-1), non-kinase signaling proteins (RasGRP4), and transcription factors involved in Th2 differentiation and allergic inflammation (STAT-6, GATA-3, NF-kappaB).
|
16364194 |
2006 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because of its involvement in other airway diseases, such as asthma, we hypothesized that Ca²⁺-activated Cl⁻ channel 1 (CLCA1) was associated with overproduction of mucus in the airways of smokers and COPD patients.
|
22731784 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results indicated that gob-5 may play a critical role in murine asthma, and its human counterpart hCLCA1 is therefore a potential target for asthma therapy.
|
11296262 |
2001 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma.
|
11842292 |
2002 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma.
|
30952704 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that CaCC1 plays a direct role in mucus production and differentiation in goblet cells and may contribute to the pathogenesis of asthma through its mucus-inducing activity.
|
11956057 |
2002 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By using gene expression microarrays, we found that chloride channel, calcium-activated, family member 1 (CLCA1), periostin, and serine peptidase inhibitor, clade B (ovalbumin), member 2 (serpinB2) were up-regulated in asthma but not in smokers.
|
17898169 |
2007 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human hCLCA1 and murine mCLCA3 (chloride channels, calcium-activated) have recently been identified as promising therapeutic targets in asthma.
|
15879574 |
2005 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, a mouse model of asthma showed that gob-5 is involved in the pathogenesis of asthma.
|
15318163 |
2004 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
With in situ hybridization, a stronger expression of CaCC1 mRNA was further detected throughout the bronchial tissues from patients with asthma than control subjects (P<0.01); Samples from asthmatics were showed a stronger staining for MUC5AC than those in control subjects (P<0.05); AB-PAS staining revealed more mucins and goblet cells in asthmatic bronchial epithelium and submucosal gland comparing to that in control subjects (P<0.05).
|
17698377 |
2007 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that adenosine cooperates with inflammatory cytokines to stimulate mucin production in the asthmatic airway and supports the use of A1, CLCA1, and EGFR inhibitors in the treatment of asthma.
|
15345696 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Recently, a mouse model of asthma showed that gob-5 is involved in the pathogenesis of asthma.
|
15318163 |
2004 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ST2L expression was increased in severe asthma (P = .02) and associated with multiple indicators of TH2-like inflammation, including blood eosinophils (P = .001), exhaled nitric oxide (P = .003), and epithelial CLCA1 (P < .0001) and eotaxin-3 (P = .001) mRNA expression.
|
25091434 |
2015 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that CLCA1 could specify a new tumor suppressor and that, as in breast cancer, CLCA2 may function as a tumor suppressor in colorectal cancer.
|
11445004 |
2001 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The data demonstrated the up-regulated TFs such as GATA-3, AP4, c-Myc and Pbx1 in the gastric mucosa of GC patients compared with the healthy volunteers, while other TFs, particularly CCAAT and CACC, showed the consistently decreasing trend along the gastric carcinogenesis.
|
26563475 |
2015 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further elucidation of the role of CLCA1 in the pathogenesis of ovarian cancer is warranted.
|
26004777 |
2015 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
Biomarker
|
disease |
BEFREE |
Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer.
|
30952704 |
2019 |
|
Channelopathies
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study hints at the therapeutic potential of the selective activation of TMEM16A by the CLCA1 VWA domain in loss-of-function chloride channelopathies such as cystic fibrosis.
|
28420732 |
2017 |
|
Chronic lung disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
They warrant evaluation of CLCA1 blockers as adjunctive therapy in this condition and describe a simple model to evaluate therapeutic interventions for steroid resistant mucus, a common condition in patients with chronic lung disease like asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
|
31333624 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Using immunostaining with an anti-CLCA1 antibody, semi-quantitative image analyses of airway epithelium demonstrated significantly increased CLCA1 expression in smokers without COPD (p = 0.02) and in COPD patients (p = 0.002) compared with non-smokers.
|
22731784 |
2012 |