|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that CLCA1 and CLCA2 are potential prognostic biomarkers for patients with colon cancer.
|
31404307 |
2019 |
|
Eosinophilia
|
0.010 |
Biomarker
|
disease |
BEFREE |
CLCA1 mRNA and periostin protein, previously identified biomarkers of IL-13-mediated epithelial activation, were elevated in columnar epithelial cell-high sputum samples, but only when accompanied by eosinophilia.
|
31264263 |
2019 |
|
von Willebrand Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also characterized a second, more catalytically active, N-terminal product of CLCA1, encompassing the catalytic domain together with its von Willebrand domain type A (VWA).
|
31570526 |
2019 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that CLCA1 and CLCA2 are potential prognostic biomarkers for patients with colon cancer.
|
31404307 |
2019 |
|
Chronic lung disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
They warrant evaluation of CLCA1 blockers as adjunctive therapy in this condition and describe a simple model to evaluate therapeutic interventions for steroid resistant mucus, a common condition in patients with chronic lung disease like asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
|
31333624 |
2019 |
|
Eosinophilic disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
CLCA1 mRNA and periostin protein, previously identified biomarkers of IL-13-mediated epithelial activation, were elevated in columnar epithelial cell-high sputum samples, but only when accompanied by eosinophilia.
|
31264263 |
2019 |
|
Neutrophilia (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Adgrf5<sup>-/-</sup> mice exhibited several features of chronic airway inflammation (mucous cell metaplasia, mucus hyperproduction, subepithelial fibrosis, respiratory acidosis, high serum IgE, mast cell accumulation, and neutrophilia) in parallel with elevated expression of genes involved in mucous cell metaplasia (Muc5ac, Muc5b, Slc26a4, and Clca1), fibrosis (Tgfb1, Col1a1, Fn1, and Tnc), and type 2 immune response (Il4, Il5, Il13, IL-25, and IL-33) at 12 and/or 30 weeks of age.
|
30654796 |
2019 |
|
Rectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In validation cohort of rectal cancers, the expression levels of CLCA1 were accessed by using immunohistochemistry assays in 172 tumor specimens that were obtained before any treatment.
|
30123054 |
2018 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition to its ability to upregulate cytokine expression which explains previous observations in the Clca1-deficient S. aureus pneumonia mouse model, modulation of BPIFA1 expression expands the role of CLCA1 in airway disease to involvement in more complex downstream pathways, possibly including liquid homeostasis, airway protection, and antimicrobial defense.
|
29610986 |
2018 |
|
Respiration Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The secreted airway mucus cell protein chloride channel regulator, calcium-activated 1, CLCA1, plays a role in inflammatory respiratory diseases via as yet unidentified pathways.
|
29610986 |
2018 |
|
Pancreatic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Low CLCA1 expression is an independent factor of poor disease-free survival in pancreatic cancer.
|
30419838 |
2018 |
|
Malignant neoplasm of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Low CLCA1 expression is an independent factor of poor disease-free survival in pancreatic cancer.
|
30419838 |
2018 |
|
Staphylococcus Aureus Pneumonia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, evidence from an in vivo Staphylococcus aureus pneumonia mouse model suggests that CLCA1 may also modify BPIFA1 expression in airway epithelial cells.
|
29610986 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
<b>Results:</b> In validation cohort, high expression of CLCA1 was significantly associated with higher pre-treatment tumor nodal stages (P=0.032), vascular invasion (P=0.028), and inferior tumor regression grade (P=0.042).
|
30123054 |
2018 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CLCA1 expression was evaluated with tissue microarrays and immunohistochemistry in 140 patients with pancreatic ductal adenocarcinoma that underwent surgical resection at Skåne University Hospital, Sweden.
|
30419838 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, CLCA1 serum concentration and mRNA expression level in CRC tissues were inversely correlated with CRC metastasis and tumor stage.
|
28974231 |
2017 |
|
Channelopathies
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study hints at the therapeutic potential of the selective activation of TMEM16A by the CLCA1 VWA domain in loss-of-function chloride channelopathies such as cystic fibrosis.
|
28420732 |
2017 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The data demonstrated the up-regulated TFs such as GATA-3, AP4, c-Myc and Pbx1 in the gastric mucosa of GC patients compared with the healthy volunteers, while other TFs, particularly CCAAT and CACC, showed the consistently decreasing trend along the gastric carcinogenesis.
|
26563475 |
2015 |
|
Secondary malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Affinity purification using the lectin HPA followed by proteomic analysis revealed annexin 4, annexin 5 and CLCA1 to be increased in the metastatic colorectal cancer specimens.
|
26495974 |
2015 |
|
Virus Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Viral infection (staining of F and G proteins, nucleoprotein RNA level), mRNA of ICAM-1, ciliated cell markers (digital high speed videomicroscopy, β-tubulin immunofluorescence, Foxj1 and Dnai2 mRNA), Goblet cells (PAS), mRNA of MUC5AC and CLCA1, mRNA and protein level of IL-13, IL-6, IL-8, TNFα, formation of H2O2 and the anti-oxidative armamentarium (mRNA of Nrf2, HO-1, GPx; total antioxidant capacity (TAC) were measured at day 10 or 15 post infection.
|
23936072 |
2013 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, RSV induced metaplastic changes to the epithelium and increased the number of goblet cells and the expression of MUC5AC and GOB5.
|
23118923 |
2012 |
|
Hepatic Encephalopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genetic analyses showed that glutaminase TACC and CACC haplotypes were linked to the risk for overt hepatic encephalopathy.
|
20820037 |
2010 |
|
Intestinal Obstruction
|
0.010 |
Biomarker
|
disease |
BEFREE |
This suggests that CLCA1 has similar important functions in CF-related intestinal obstruction in humans as in Cftr-/- mice.
|
20179644 |
2010 |
|
Meconium ileus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to investigate whether the p.S357N variant in CLCA1, the human orthologue of Clca3, acts as a modifier gene in a cohort of 682 European patients with cystic fibrosis (CF)-99 patients with meconium ileus.
|
20179644 |
2010 |
|
Hypertriglyceridemia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Analysis of the two major SNPs from APOA5 [c.56C > G, c.-3A > G] and from APOC3 [c.102C > T, c.340C > G] using THESIAS has identified two major haplotypes relative to the most common CACC haplotype showing very strong association with hypertriglyceridaemia, CGTG and GATC (odds ratio 7.45 and 5.26).
|
16125709 |
2006 |