|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
<b>Results:</b> In validation cohort, high expression of CLCA1 was significantly associated with higher pre-treatment tumor nodal stages (P=0.032), vascular invasion (P=0.028), and inferior tumor regression grade (P=0.042).
|
30123054 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
<b>Results:</b> In validation cohort, high expression of CLCA1 was significantly associated with higher pre-treatment tumor nodal stages (P=0.032), vascular invasion (P=0.028), and inferior tumor regression grade (P=0.042).
|
30123054 |
2018 |
|
Virus Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Viral infection (staining of F and G proteins, nucleoprotein RNA level), mRNA of ICAM-1, ciliated cell markers (digital high speed videomicroscopy, β-tubulin immunofluorescence, Foxj1 and Dnai2 mRNA), Goblet cells (PAS), mRNA of MUC5AC and CLCA1, mRNA and protein level of IL-13, IL-6, IL-8, TNFα, formation of H2O2 and the anti-oxidative armamentarium (mRNA of Nrf2, HO-1, GPx; total antioxidant capacity (TAC) were measured at day 10 or 15 post infection.
|
23936072 |
2013 |
|
Chronic Obstructive Airway Disease
|
0.030 |
GeneticVariation
|
disease |
LHGDN |
CLCA1 gene polymorphisms in chronic obstructive pulmonary disease.
|
14985398 |
2004 |
|
airway disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
CLCA1 and TMEM16A: the link towards a potential cure for airway diseases.
|
26296094 |
2015 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway.
|
28974231 |
2017 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CLCA1 expression was evaluated with tissue microarrays and immunohistochemistry in 140 patients with pancreatic ductal adenocarcinoma that underwent surgical resection at Skåne University Hospital, Sweden.
|
30419838 |
2018 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
CLCA1 expression was denoted as positive in 90 tumors (64.3%), with positive staining being limited to the tumor cells.
|
30419838 |
2018 |
|
airway disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma.
|
30952704 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma.
|
30952704 |
2019 |
|
Eosinophilia
|
0.010 |
Biomarker
|
disease |
BEFREE |
CLCA1 mRNA and periostin protein, previously identified biomarkers of IL-13-mediated epithelial activation, were elevated in columnar epithelial cell-high sputum samples, but only when accompanied by eosinophilia.
|
31264263 |
2019 |
|
Eosinophilic disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
CLCA1 mRNA and periostin protein, previously identified biomarkers of IL-13-mediated epithelial activation, were elevated in columnar epithelial cell-high sputum samples, but only when accompanied by eosinophilia.
|
31264263 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma.
|
11842292 |
2002 |
|
Metaplasia
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction.
|
12568493 |
2002 |
|
Neutrophilia (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Adgrf5<sup>-/-</sup> mice exhibited several features of chronic airway inflammation (mucous cell metaplasia, mucus hyperproduction, subepithelial fibrosis, respiratory acidosis, high serum IgE, mast cell accumulation, and neutrophilia) in parallel with elevated expression of genes involved in mucous cell metaplasia (Muc5ac, Muc5b, Slc26a4, and Clca1), fibrosis (Tgfb1, Col1a1, Fn1, and Tnc), and type 2 immune response (Il4, Il5, Il13, IL-25, and IL-33) at 12 and/or 30 weeks of age.
|
30654796 |
2019 |
|
Secondary malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Affinity purification using the lectin HPA followed by proteomic analysis revealed annexin 4, annexin 5 and CLCA1 to be increased in the metastatic colorectal cancer specimens.
|
26495974 |
2015 |
|
Hypertriglyceridemia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Analysis of the two major SNPs from APOA5 [c.56C > G, c.-3A > G] and from APOC3 [c.102C > T, c.340C > G] using THESIAS has identified two major haplotypes relative to the most common CACC haplotype showing very strong association with hypertriglyceridaemia, CGTG and GATC (odds ratio 7.45 and 5.26).
|
16125709 |
2006 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because of its involvement in other airway diseases, such as asthma, we hypothesized that Ca²⁺-activated Cl⁻ channel 1 (CLCA1) was associated with overproduction of mucus in the airways of smokers and COPD patients.
|
22731784 |
2012 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By using gene expression microarrays, we found that chloride channel, calcium-activated, family member 1 (CLCA1), periostin, and serine peptidase inhibitor, clade B (ovalbumin), member 2 (serpinB2) were up-regulated in asthma but not in smokers.
|
17898169 |
2007 |
|
ovarian neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer.
|
30952704 |
2019 |
|
Malignant neoplasm of ovary
|
0.020 |
Biomarker
|
disease |
BEFREE |
Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer.
|
30952704 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
Biomarker
|
disease |
BEFREE |
Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer.
|
30952704 |
2019 |
|
ovarian neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further elucidation of the role of CLCA1 in the pathogenesis of ovarian cancer is warranted.
|
26004777 |
2015 |
|
Malignant neoplasm of ovary
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further elucidation of the role of CLCA1 in the pathogenesis of ovarian cancer is warranted.
|
26004777 |
2015 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further elucidation of the role of CLCA1 in the pathogenesis of ovarian cancer is warranted.
|
26004777 |
2015 |