|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma.
|
30952704 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ST2L expression was increased in severe asthma (P = .02) and associated with multiple indicators of TH2-like inflammation, including blood eosinophils (P = .001), exhaled nitric oxide (P = .003), and epithelial CLCA1 (P < .0001) and eotaxin-3 (P = .001) mRNA expression.
|
25091434 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 3-gene signature of periostin, chloride channel accessory 1 (CLCA1), and Serpin β2 (SERPINB2) in airway epithelial brushings is used to classify asthma into TH2-high and TH2-low endotypes.
|
24075231 |
2014 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because of its involvement in other airway diseases, such as asthma, we hypothesized that Ca²⁺-activated Cl⁻ channel 1 (CLCA1) was associated with overproduction of mucus in the airways of smokers and COPD patients.
|
22731784 |
2012 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By using gene expression microarrays, we found that chloride channel, calcium-activated, family member 1 (CLCA1), periostin, and serine peptidase inhibitor, clade B (ovalbumin), member 2 (serpinB2) were up-regulated in asthma but not in smokers.
|
17898169 |
2007 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
With in situ hybridization, a stronger expression of CaCC1 mRNA was further detected throughout the bronchial tissues from patients with asthma than control subjects (P<0.01); Samples from asthmatics were showed a stronger staining for MUC5AC than those in control subjects (P<0.05); AB-PAS staining revealed more mucins and goblet cells in asthmatic bronchial epithelium and submucosal gland comparing to that in control subjects (P<0.05).
|
17698377 |
2007 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Potential anti-mRNA drugs in asthma and other allergic disorders may be targeted to cell surface receptors (adenosine A1 receptor, high-affinity receptor Fc-epsilon RI-alpha, cytokine receptors), adhesion molecules and ligands (ICAM-1, VLA-4), ion channels (calcium-dependent chloride channel-1), cytokines and related factors (IL-4, IL-5, IL-13, SCF, TNF-alpha, TGF-beta1), intracellular signal transduction molecules, such as tyrosine-protein kinases (Syk, Lyn, Btk), serine/ threonine-protein kinases (p38 alpha MAPkinase, Raf-1), non-kinase signaling proteins (RasGRP4), and transcription factors involved in Th2 differentiation and allergic inflammation (STAT-6, GATA-3, NF-kappaB).
|
16364194 |
2006 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Oxidant stress stimulates Ca2+-activated chloride channels in the apical activated membrane of cultured nonciliated human nasal epithelial cells.
|
16148052 |
2005 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human hCLCA1 and murine mCLCA3 (chloride channels, calcium-activated) have recently been identified as promising therapeutic targets in asthma.
|
15879574 |
2005 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, a mouse model of asthma showed that gob-5 is involved in the pathogenesis of asthma.
|
15318163 |
2004 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that adenosine cooperates with inflammatory cytokines to stimulate mucin production in the asthmatic airway and supports the use of A1, CLCA1, and EGFR inhibitors in the treatment of asthma.
|
15345696 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Recently, a mouse model of asthma showed that gob-5 is involved in the pathogenesis of asthma.
|
15318163 |
2004 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma.
|
11842292 |
2002 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that CaCC1 plays a direct role in mucus production and differentiation in goblet cells and may contribute to the pathogenesis of asthma through its mucus-inducing activity.
|
11956057 |
2002 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results indicated that gob-5 may play a critical role in murine asthma, and its human counterpart hCLCA1 is therefore a potential target for asthma therapy.
|
11296262 |
2001 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
They warrant evaluation of CLCA1 blockers as adjunctive therapy in this condition and describe a simple model to evaluate therapeutic interventions for steroid resistant mucus, a common condition in patients with chronic lung disease like asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
|
31333624 |
2019 |
|
Cystic Fibrosis
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Our study hints at the therapeutic potential of the selective activation of TMEM16A by the CLCA1 VWA domain in loss-of-function chloride channelopathies such as cystic fibrosis.
|
28420732 |
2017 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
This suggests that CLCA1 has similar important functions in CF-related intestinal obstruction in humans as in Cftr-/- mice.
|
20179644 |
2010 |
|
Cystic Fibrosis
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Therefore the role of hCLCA1 as a mediator of mucus overexpression in CF has to be questioned.
|
20542744 |
2010 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
The results suggest that pCLCA1 shares essential characteristics of hCLCA1, supporting the pig model as a promising tool for studying the modulating role of pCLCA1 in the complex pathology of CF.
|
19755716 |
2009 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
LHGDN |
The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.
|
15490240 |
2004 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
These findings suggest that human CLCA1 mediates a Ca2+-activated Cl- conductance in the human intestine and make it an interesting candidate as a modulating factor in the pathogenesis of cystic fibrosis.
|
9828122 |
1998 |
|
Colorectal Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
We finally established a five-gene signature (kinesin family member 15, N-acetyltransferase 2, glutathione peroxidase 3, secretogranin II, and chloride channel accessory 1) with prognostic value in CRC by step multivariate Cox regression analysis.
|
30132881 |
2019 |
|
Colorectal Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Thus, CEACAM7, SLC4A4, GCG and CLCA1 may be prognostic markers or therapeutic targets of CRC.
|
31612015 |
2019 |
|
Colorectal Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
In addition, CLCA1 serum concentration and mRNA expression level in CRC tissues were inversely correlated with CRC metastasis and tumor stage.
|
28974231 |
2017 |