CLCA1, chloride channel accessory 1, 1179

N. diseases: 42; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.070 Biomarker disease BEFREE These findings suggest that human CLCA1 mediates a Ca2+-activated Cl- conductance in the human intestine and make it an interesting candidate as a modulating factor in the pathogenesis of cystic fibrosis. 9828122 1998
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE Our results indicated that gob-5 may play a critical role in murine asthma, and its human counterpart hCLCA1 is therefore a potential target for asthma therapy. 11296262 2001
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.060 Biomarker disease BEFREE Our results suggest that CLCA1 could specify a new tumor suppressor and that, as in breast cancer, CLCA2 may function as a tumor suppressor in colorectal cancer. 11445004 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 Biomarker group BEFREE Our results suggest that CLCA1 could specify a new tumor suppressor and that, as in breast cancer, CLCA2 may function as a tumor suppressor in colorectal cancer. 11445004 2001
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.020 Biomarker disease BEFREE Our results suggest that CLCA1 could specify a new tumor suppressor and that, as in breast cancer, CLCA2 may function as a tumor suppressor in colorectal cancer. 11445004 2001
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 Biomarker disease BEFREE Our results suggest that CLCA1 could specify a new tumor suppressor and that, as in breast cancer, CLCA2 may function as a tumor suppressor in colorectal cancer. 11445004 2001
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 Biomarker disease BEFREE Our results suggest that CLCA1 could specify a new tumor suppressor and that, as in breast cancer, CLCA2 may function as a tumor suppressor in colorectal cancer. 11445004 2001
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma. 11842292 2002
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE These results suggest that CaCC1 plays a direct role in mucus production and differentiation in goblet cells and may contribute to the pathogenesis of asthma through its mucus-inducing activity. 11956057 2002
CUI: C0025568
Disease: Metaplasia
Metaplasia 		0.010 Biomarker phenotype LHGDN A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction. 12568493 2002
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE Recently, a mouse model of asthma showed that gob-5 is involved in the pathogenesis of asthma. 15318163 2004
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE These results suggest that adenosine cooperates with inflammatory cytokines to stimulate mucin production in the asthmatic airway and supports the use of A1, CLCA1, and EGFR inhibitors in the treatment of asthma. 15345696 2004
CUI: C0004096
Disease: Asthma
Asthma 		0.100 GeneticVariation disease LHGDN Recently, a mouse model of asthma showed that gob-5 is involved in the pathogenesis of asthma. 15318163 2004
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.070 Biomarker disease LHGDN The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis. 15490240 2004
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.030 GeneticVariation disease LHGDN CLCA1 gene polymorphisms in chronic obstructive pulmonary disease. 14985398 2004
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease LHGDN Oxidant stress stimulates Ca2+-activated chloride channels in the apical activated membrane of cultured nonciliated human nasal epithelial cells. 16148052 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE The human hCLCA1 and murine mCLCA3 (chloride channels, calcium-activated) have recently been identified as promising therapeutic targets in asthma. 15879574 2005
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.010 AlteredExpression disease BEFREE mRNAs for kNBC, KCC1 and -4 and all the CaCC families (CaCC1, -2 and -3) are expressed in human turbinate mucosa and nasal polyp. 16012037 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE Potential anti-mRNA drugs in asthma and other allergic disorders may be targeted to cell surface receptors (adenosine A1 receptor, high-affinity receptor Fc-epsilon RI-alpha, cytokine receptors), adhesion molecules and ligands (ICAM-1, VLA-4), ion channels (calcium-dependent chloride channel-1), cytokines and related factors (IL-4, IL-5, IL-13, SCF, TNF-alpha, TGF-beta1), intracellular signal transduction molecules, such as tyrosine-protein kinases (Syk, Lyn, Btk), serine/ threonine-protein kinases (p38 alpha MAPkinase, Raf-1), non-kinase signaling proteins (RasGRP4), and transcription factors involved in Th2 differentiation and allergic inflammation (STAT-6, GATA-3, NF-kappaB). 16364194 2006
CUI: C0035235
Disease: Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Infections 		0.020 AlteredExpression group BEFREE To demonstrate a causative link, we depleted TLR3-/- mice of IL-13 during RSV infection and found that mucus and gob5 expression in the lungs was attenuated. 16424225 2006
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia 		0.010 GeneticVariation phenotype BEFREE Analysis of the two major SNPs from APOA5 [c.56C > G, c.-3A > G] and from APOC3 [c.102C > T, c.340C > G] using THESIAS has identified two major haplotypes relative to the most common CACC haplotype showing very strong association with hypertriglyceridaemia, CGTG and GATC (odds ratio 7.45 and 5.26). 16125709 2006
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE By using gene expression microarrays, we found that chloride channel, calcium-activated, family member 1 (CLCA1), periostin, and serine peptidase inhibitor, clade B (ovalbumin), member 2 (serpinB2) were up-regulated in asthma but not in smokers. 17898169 2007
CUI: C0004096
Disease: Asthma
Asthma 		0.100 AlteredExpression disease BEFREE With in situ hybridization, a stronger expression of CaCC1 mRNA was further detected throughout the bronchial tissues from patients with asthma than control subjects (P<0.01); Samples from asthmatics were showed a stronger staining for MUC5AC than those in control subjects (P<0.05); AB-PAS staining revealed more mucins and goblet cells in asthmatic bronchial epithelium and submucosal gland comparing to that in control subjects (P<0.05). 17698377 2007
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.070 Biomarker disease BEFREE The results suggest that pCLCA1 shares essential characteristics of hCLCA1, supporting the pig model as a promising tool for studying the modulating role of pCLCA1 in the complex pathology of CF. 19755716 2009
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.070 Biomarker disease BEFREE This suggests that CLCA1 has similar important functions in CF-related intestinal obstruction in humans as in Cftr-/- mice. 20179644 2010