|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Aberrant activation of Wnt signaling caused by mutations in the tumor suppressor adenomatous polyposis coli or beta-catenin is a critical event in the development of human colorectal tumors.
|
12417602 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
LHGDN |
The APC/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: a mutational analysis.
|
11920497 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Nuclear beta-catenin expression is closely related to ulcerative growth of colorectal carcinoma.
|
11953860 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.
|
12209953 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
These results suggest that although there may be a number of mechanisms responsible for changes in beta-catenin expression in colorectal tumors, dysfunction of APC may be the major cause of this phenomenon.
|
11956815 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Aberrant activation of Wnt signaling caused by mutations in adenomatous polyposis coli (APC) or beta-catenin is a critical event in the development of human colorectal tumors.
|
12036951 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Mutations in APC and beta-catenin, despite occurring in the same genetic pathway, show differing biological properties, a phenomenon that has previously been demonstrated in colorectal neoplasms.
|
12414520 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
TCF-4 and beta-catenin form a transcription complex, which is important for both maintenance of normal epithelium and development of colorectal tumors.
|
12036905 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Alterations of phosphorylation sites within the CTNNB1 gene, which codes for beta-catenin has been reported to occur in about one-half of colorectal tumors without APC-gene mutations.
|
11454429 |
2001 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
More frequent beta-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated rats.
|
10965019 |
2000 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We therefore used PCR to amplify and sequence exon 3 of beta-catenin from 202 sporadic colorectal tumors.
|
10197610 |
1999 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer.
|
10493496 |
1999 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Some colorectal tumors with wild-type adenomatous polyposis coli gene have activating mutations in beta-catenin (encoded by CTNNB1) that result in decreased phosphorylation by GSK-3beta and increased signaling through the Tcf/Lef transcription factors.
|
10416591 |
1999 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Our results indicate that somatic beta-catenin activating mutations contribute only to a minor part of human colorectal tumors and that germline beta-catenin mutations do not play a role in the variability of symptoms in FAP.
|
9591632 |
1998 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
It is concluded that the patterns of expression of E-cadherin and alpha- and beta-catenin are very similar in colorectal neoplasms.
|
9349236 |
1997 |