|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Excluding noncompliance with GC treatment, abnormal steroid pharmacokinetics, and rare genetic defects in the glucocorticoid receptor (GR), the majority of GC insensitivity in asthma can be attributed to secondary defects related to GR function.
|
24162914 |
2014 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, the relationship between airway eosinophilia and the expression of FK506-binding protein 51 (FKBP51), a glucocorticoid receptor co-chaperone that plays a role in steroid insensitivity in asthma, remains unknown.
|
23762334 |
2013 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In patients with severe asthma, several molecular mechanisms have been identified that might account for reduced steroid responsiveness, including reduced nuclear translocation of glucocorticoid receptor (GR) α after binding corticosteroids.
|
23360759 |
2013 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.
|
22156779 |
2012 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The N363S polymorphism of NR3C1 gene is significantly associated with bronchial asthma, susceptibility to the development of moderate to severe form of uncontrolled bronchial asthma.
|
22015776 |
2012 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of this research project was to study the correlation between the N363S and I559N polymorphisms of the h-GR/NR3C1 gene and the occurrence of asthma in a population of Polish asthmatics.
|
22469783 |
2012 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The Bcl I polymorphism of h-GR/NR3C1 gene is significantly associated with bronchial asthma, susceptibility to the development of severe form and resistance to GCs in Polish population.
|
21113676 |
2011 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
To evaluate expression and interaction of HDACs with glucocorticoid receptor isoforms in bronchoalveolar lavage and peripheral blood mononuclear cells from steroid-resistant versus steroid-sensitive patients with asthma.
|
20538962 |
2010 |
|
Asthma
|
0.300 |
Therapeutic
|
disease |
RGD |
Medicinal extract for tonifying kidney to relieve asthma can increase the expression of GR in lung tissues of asthmatic rats, which may be one of its mechanisms in preventing and treating asthma.
|
20727335 |
2010 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In males, no change to cortisol, birth weight or placental GR were evident in pregnancies with asthma.
|
20627904 |
2010 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Impaired nuclear entry of GR has been documented in steroid-non-responsive asthmatics.
|
19619331 |
2009 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoids.
|
18952539 |
2008 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Understanding the molecular mechanisms of GR action and inaction may lead to the development of new anti-inflammatory drugs or enable clinicians to reverse the relative steroid-insensitivity that is characteristic of some patients with severe asthma.
|
18417060 |
2008 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Gene mutations that are known to alter the response to asthma therapy include Arg/Arg atr position 16, mutations of LTC4S, ALOX5, and GR/NR3C1, increased expression of GR , CRHR1 variants, and mutations in CYP1A2 (-22964 [G/A]), and T 314 allele for histamine N-methyltransferase.
|
17672811 |
2007 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma.
|
16387802 |
2006 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Life stress and diminished expression of genes encoding glucocorticoid receptor and beta2-adrenergic receptor in children with asthma.
|
16567656 |
2006 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma.
|
16387802 |
2006 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We reasoned that, because many cytokine genes activated in asthma are transcriptionally regulated by the recruitment of this complex to DNA, their binding sites might provide a target for GR to mediate its repressive effects.
|
15826950 |
2005 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Recently a causative role for a splicing variant of the glucocorticoid receptor (hGR beta) has been proposed in glucocorticoid resistance in asthma and ulcerative colitis, whereas another splicing variant (hGR P) might be associated with glucocorticoid-resistant haematological malignancies.
|
15635817 |
2004 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Glucocorticoids activated the glucocorticoid receptor and inhibited serum-induced secretion of interleukin-6 in bronchial smooth-muscle cells from both subjects with asthma and those without asthma; however, glucocorticoids inhibited proliferation only in bronchial smooth-muscle cells from subjects without asthma.
|
15295049 |
2004 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
LHGDN |
[Response to glucocorticoid treatment in asthma. The role of alpha and beta isoforms of the glucocorticoid receptor].
|
12237016 |
2002 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Expression of c-fos, rather than c-jun or glucocorticoid-receptor mRNA, correlates with decreased glucocorticoid response of peripheral blood mononuclear cells in asthma.
|
12400872 |
2002 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
While incubated with combination of IL-2 and IL-4, a significantly higher expression of GR mRNA was observed in all asthmatics, and a significantly higher expression of HSP90 mRNA was observed only in SS and SD patients.
|
11677765 |
2001 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We investigated whether the incapacity of GC to inhibit production of these cytokines in vivo was the result of a dysregulation of the glucocorticoid receptor (GR) in GC-dependent asthma.
|
10903212 |
2000 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our data suggest that delivery of the GR gene in vivo may reduce inflammation without recourse to GC and may constitute an alternative therapeutic approach for corticoresistant asthma.
|
10435109 |
1999 |