|
Carcinoma, Cribriform
|
0.300 |
Biomarker
|
disease |
CTD_human |
Diverse proteomic alterations in gastric adenocarcinoma.
|
15378696 |
2004 |
|
Carcinoma, Granular Cell
|
0.300 |
Biomarker
|
disease |
CTD_human |
Diverse proteomic alterations in gastric adenocarcinoma.
|
15378696 |
2004 |
|
Adenocarcinoma, Tubular
|
0.300 |
Biomarker
|
disease |
CTD_human |
Diverse proteomic alterations in gastric adenocarcinoma.
|
15378696 |
2004 |
|
Hereditary Diffuse Gastric Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
Diverse proteomic alterations in gastric adenocarcinoma.
|
15378696 |
2004 |
|
Reperfusion Injury
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Heat-shock protein-73 protects against small intestinal warm ischemia-reperfusion injury in the rat.
|
10216529 |
1999 |
|
Metabolic Diseases
|
0.210 |
AlteredExpression
|
group |
BEFREE |
Our work identified Hsc70 and its ATPase activity as a central cofactor of TRPV1 channel function and points to the role of this stress protein in pain associated with neurodegenerative and/or metabolic disorders, including aging.
|
27558883 |
2016 |
|
Metabolic Diseases
|
0.210 |
Biomarker
|
group |
RGD |
Our findings demonstrated that HSP73 and HSP90 chaperone proteins specifically accumulated within lysosomes of proximal tubular epithelial cells during the course of PDGA-induced acute lysosomal thesaurismosis.
|
10469394 |
1999 |
|
Brain Ischemia
|
0.200 |
Biomarker
|
disease |
RGD |
Irreversible aggregation of protein synthesis machinery after focal brain ischemia.
|
16805800 |
2006 |
|
Liver Failure, Acute
|
0.200 |
Biomarker
|
disease |
RGD |
Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage.
|
15270078 |
2004 |
|
Acute kidney injury
|
0.200 |
Biomarker
|
disease |
RGD |
73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin.
|
14966137 |
2004 |
|
Chemical and Drug Induced Liver Injury
|
0.200 |
Biomarker
|
disease |
RGD |
Immunohistochemical studies on the expression pattern of molecular chaperones HSC70 and HSP25 and cell cycle-related proteins cyclin D1 and PCNA in rat liver after thioacetamide intoxication.
|
12376827 |
2002 |
|
Paraneoplastic Syndromes, Ocular
|
0.200 |
Biomarker
|
disease |
RGD |
Cancer-associated retinopathy induced by both anti-recoverin and anti-hsc70 antibodies in vivo.
|
10586938 |
1999 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Assembly of proteins to postsynaptic densities after transient cerebral ischemia.
|
9425004 |
1998 |
|
Graft-vs-Host Disease
|
0.200 |
Biomarker
|
disease |
RGD |
Expression of 70-kDa heat-shock protein during acute graft-versus-host disease.
|
9557158 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, we show that intercellular antigen transfer of DBY is tightly regulated via binding to HSC70 and that this mechanism influences recognition and rejection of MHC-II-negative tumors in vivo.
|
31205025 |
2019 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Phosphorylation of PED switches its function from tumor suppression to tumor promotion, and we show that HSC70 preferentially targets the unphosphorylated form of PED to CMA.
|
24477641 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The aim was to determine whether ultrasound targeted microbubble destruction (UTMD) promotes dual targeting of HSP72 and HSC70 for therapy of castration-resistant prostate cancer (CRPC), to improve the specific and efficient delivery of siRNA, to induce tumor cell specific apoptosis, and to find new therapeutic targets specific of CRPC.VCaP cells were transfected with siRNA oligonucleotides.
|
24606454 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, Hsc70 was associated with NCL-induced endothelial cell migration and tubule formation in vitro and angiogenesis in both matrigel plugs and xenograft tumors.
|
22743058 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Stable transfection of ST6GalNAcV into U373MG glioma cells produced (i) no change in alpha2,6-linked sialic acid-containing glycoproteins, (ii) increased expression of GM2alpha and GM3 gangliosides and decreased expression of GM1b, Gb3, and Gb4, (iii) marked inhibition of in vitro invasivity, (iv) modified cellular adhesion to fibronectin and laminin, (v) increased adhesion-mediated protein tyrosine phosphorylation of HSPA8, and (vi) inhibition of tumor growth in vivo.
|
20616019 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest a new role of this secreted hsc70 chaperone in cell proliferation that might account for the higher tumor growth of cancer cells overexpressing cath D.
|
19802014 |
2010 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Tumors with weak (+) HSC70 protein staining were more frequent in the carriers of the polymorphic 1541-1542delGT allele than in the homozygotes of the major allele (20% vs. 6%, P=0.05 by Fisher's exact test).
|
14991745 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition to melanoma, gastric and uterus cancer tissues exhibited higher HSP73 mRNA expression on a matched tumour/normal cDNA array than their normal counterparts which was statistically significant.
|
15254721 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Hsc70 down-regulation might reflect a functional integration of the overexpressed Hsp70 on the basis of a chaperone network so that only acute induction will provide Hsp70 that can improve tumor cell lysability.
|
14678977 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HSC70 was also detected in the majority (97%) of cases, although expression was not correlated with BAG-1 levels, oestrogen receptor status or tumour grade.
|
12081204 |
2002 |