|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its expression is reduced or lost in several cancers, including breast cancer.
|
29510992 |
2018 |
|
Breast Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
HSP70-2 P1/P2, HSPA8 intronic 1541-1542delGT and HIF-1 alpha polymorphisms were not associated with breast cancer risk, as evidenced by the dose-response allele models.
|
23065205 |
2012 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Hsc70 appears active in human breast cancer cells and hypersecreted by direct cath D inhibition.
|
19802014 |
2010 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth.
|
19800331 |
2009 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the impact of Hsp70 protein expression, and its close family member, Hsc70, on breast cancer cell viability and on the activity of the Hsp90/Hsp70 chaperone complex, a complex whose activity is important for the survival of cancer cells and tumours.
|
17487411 |
2007 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Somatic mutations of 11q23.3-linked constitutive heat shock protein 70 gene (HSPA8 alias HSC70) are detected by others in breast carcinomas.
|
14991745 |
2004 |
|
Breast Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
In both cases, mutation was coincident with allelic imbalance, suggesting that HSC70 is a target of somatic mutation and deletion in a fraction of breast carcinomas.
|
10485459 |
1999 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Here, we report the interaction between the human Hsp70 isoform heat shock cognate 71-kDa protein (Hsc70 or HSPA8) and peptides derived from the microtubule-associated protein Tau, which is linked to Alzheimer's disease.
|
29764935 |
2018 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the effects of a small-molecule HSC70 inhibitor, VER-155008, on axonal morphology and memory function in a mouse model of AD (5XFAD mice).
|
29441022 |
2018 |
|
Alzheimer's Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Our study indicated that reducing the HSC70 level is a new possible therapeutic target of axonal regeneration in AD.
|
30076345 |
2018 |
|
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its expression is reduced or lost in several cancers, including breast cancer.
|
29510992 |
2018 |
|
Alzheimer's Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
A significant downregulation of HSPA8 and HSPA9 was observed in AD across the three brain regions compared to the controls, suggesting their participation in AD pathogenesis.
|
23948933 |
2014 |
|
Malignant neoplasm of breast
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
HSP70-2 P1/P2, HSPA8 intronic 1541-1542delGT and HIF-1 alpha polymorphisms were not associated with breast cancer risk, as evidenced by the dose-response allele models.
|
23065205 |
2012 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
The expression levels of the chaperone-mediated autophagy proteins LAMP2A and hsc70 were significantly reduced in the substantia nigra pars compacta and amygdala of PD brains compared with age-matched AD and control brain samples.
|
20697033 |
2010 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Hsc70 appears active in human breast cancer cells and hypersecreted by direct cath D inhibition.
|
19802014 |
2010 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth.
|
19800331 |
2009 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the impact of Hsp70 protein expression, and its close family member, Hsc70, on breast cancer cell viability and on the activity of the Hsp90/Hsp70 chaperone complex, a complex whose activity is important for the survival of cancer cells and tumours.
|
17487411 |
2007 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The results showed that Hsc70 deficiency significantly retarded migration and invasion and reduced the phosphorylation of FAK, Src, and Pyk2 in U251 and U87 cells.
|
30816582 |
2019 |
|
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Mechanistically, TXNDC5 directly interacts with heat shock cognate 70 protein (HSC70) to sequester it in the cytoplasm, and HSC70 silencing exerts the same effects as TXNDC5 on the biological activity of RASFs (for example, decreased cell viability, invasion and cytokine production).
|
28603283 |
2018 |
|
Dystonia
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
These scientific contributions strengthen the role of LAP1 in DYT1 dystonia and muscular dystrophy.
|
26596547 |
2016 |
|
Dystonia Disorders
|
0.040 |
Biomarker
|
group |
BEFREE |
These scientific contributions strengthen the role of LAP1 in DYT1 dystonia and muscular dystrophy.
|
26596547 |
2016 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Subsequently, we found that LAP1 repressed HCC cell migration and invasion via the induction of ORM2 expression.
|
25965830 |
2015 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, nestin regulates stemness, cell growth, and invasion in glioblastoma cells through the alteration of HSC71.
|
25527454 |
2015 |
|
Dystonia
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Moreover, LAP1 also interacts with torsinA and emerin, proteins involved in DYT1 dystonia and X-linked Emery-Dreifuss muscular dystrophy disorder, respectively.
|
25461922 |
2014 |
|
Dystonia
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
LAP1 interacts with torsinA, the protein mutated in DYT1-dystonia.
|
25425325 |
2014 |