|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Coinfection resulted in greater type I and II IFN production in the lung compared with that with virus infection alone.
|
21178015 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that FADD and TRIM21 together negatively regulate the late IFN-α pathway in response to viral infection.
|
21183682 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest that IL-13 may be a putative cytokine suppressing IFN-λ production against airway viral infections in asthmatics.
|
21184733 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
To our knowledge, this is the first report to describe the simultaneous suppression of type I IFN and induction of type III IFN after virus infection.
|
21278349 |
2011 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These ISGs all contained an IFN regulatory factor 1 (IRF-1) binding site in their promoters, and their expression was shown to be driven by IRF-1, indicating this subset was induced directly by viral infection by IRF-1.
|
21411754 |
2011 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In vivo and ex vivo models of reoviral encephalitis were utilized to delineate the contribution of type I interferon (IFN) to the host's defense against local central nervous system (CNS) viral infection and systemic viral spread.Following intracranial (i.c.) inoculation with either serotype 3 (T3) or serotype 1 (T1) reovirus, increased expression of IFN-α, IFN-β, and myxovirus-resistance protein (Mx1; a prototypical IFN stimulated gene) was observed in mouse brain tissue.
|
21671121 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
During its migration in the nervous system (NS), RABV triggers an innate immune response, including a type I IFN response well known to limit viral infections.
|
21805057 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Although IFN-λs and classical type I IFNs (IFN-α/β) utilize distinct receptor complexes for signaling, both types of IFNs activate similar intracellular signaling pathways and biological activities, including the ability to induce antiviral state in cells, and both type I and type III IFNs are induced by viral infection.
|
21840693 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The actions of IFN-stimulated genes (ISGs) impart control of virus infection, but the specific ISGs and regulatory pathways that restrict West Nile virus (WNV) are not defined.
|
22065572 |
2011 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We also found that IFNα-Receptor knockout mice failed to induce Dll1 expression on lung macrophages and had enhanced mortality during influenza virus infection.
|
22072963 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interferon regulatory factor 2 (IRF2) is a member of a family of transcriptional factors involved in the modulation of IFN-induced immune responses to viral infection.
|
22113474 |
2012 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Lung cancer cells can be partially protected from viral killing using IRF5+IRF7 overexpression, whereas IFN pathway disruption by transfection of siRNAs to IRF5+IRF7 increases cells' vulnerability to viral infection.
|
22194884 |
2011 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We then examined cells with single or multiple virus infections for the expression of 10 cytokine genes and demonstrated elevated expressions for 7 (IFN-α, IFN-β, IFN-γ, TNF-α, IL-6, IL-8, and IL-17) in dual rotavirus and enterovirus or triple rotavirus, enterovirus and astrovirus-infected cells but only 3 (IFN-β, TNF-α, and IL-8) in dual rotavirus and astrovirus-infected cells.
|
22497974 |
2012 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Pretreatment blood samples of patients receiving a full course of PEG-IFN and RBV were used to assess expression of 153 genes previously implicated in host response to viral infections.
|
22571903 |
2012 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type I interferons (IFNs), including IFN-α, -β, and -ω, play a critical role in innate immune responses against viral infection.
|
22685015 |
2012 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Induction of Type I Interferon (IFN) genes constitutes an essential step leading to innate immune responses during virus infection.
|
22685561 |
2012 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These studies suggest that inadequate IFN-α/β responses following virus infection can be sufficient to induce hemorrhagic fever and shock, a finding with implications for understanding severe CHIKV disease and dengue hemorrhagic fever/dengue shock syndrome.
|
22761364 |
2012 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Toll-like receptor 3 (TLR3) plays a critical role in initiating type I IFN-mediated innate immunity against viral infections.
|
23035017 |
2013 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This discovery not only reveals a regulatory pathway for controlling IFN-α1 gene expression during the host innate immune response against virus infection but also suggests a reason for the large number of overlapping complementary transcripts with previously unknown function.
|
23224365 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Combinations of antivirals with additive potency that lack cross-resistance and with a good safety profile may provide new regimens in the future to make HCV the first chronic viral infection to be eradicated worldwide with a finite duration of combination DAA therapy without IFN.
|
23286852 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
TBK1 mediates the activation of interferon regulatory factor (IRF) 3, leading to the induction of type I IFNs (IFN-α/β) following viral infections.
|
23395611 |
2013 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The major components of the RIG-I- and TLR pathways have putatively been identified, but previously unrecognised kinases may contribute to virus infection-induced activation of the IFN response.
|
23405030 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Virus infection can initiate a type I interferon (IFN-α/β) response via activation of the cytosolic RNA sensors retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5).
|
23536668 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Currently IFN-α is widely used for effective treatment of viral infections and several malignancies.
|
23590859 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In the near future, combination of antiviral agents with additive potency that lack cross-resistance with good safety profile will likely be the new recommended regimens, making HCV, the first chronic viral infection to be eradicated worldwide with a finite duration of combination DAA therapy without IFN or ribavirin.
|
24373081 |
2014 |