|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In response to viral infection, the host induces over 300 IFN-stimulated genes (ISGs), which are the central component of intracellular antiviral innate immunity.
|
24449862 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
When the effect of the inhibition on the cells infected with hepatitis C virus (HCV) was examined, the significant decrease of IFN stimulated gene expression and the enhancement of initial HCV replication were observed, suggesting that the steady-state production of IFN-α plays a role in amplification of antiviral responses to control the spread of RNA viral infection in human hepatocytes.
|
24587086 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
SCARB2 or PSGL-1 receptor binding is the first step in the development of viral infections, and viral factors (e.g., 5' UTR, VP1, 3C, 3D, 3' UTR), host factors and environments (e.g., ITAFs, type I IFN) are also involved in viral infections.
|
24602216 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We show that mice lacking the IFN receptor on either CD11c- or LysM-expressing cells (conditional IFNAR mice) are susceptible to dengue virus infection.
|
24741106 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN-α 2b therapy maybe useful in controlling recalcitrant viral infections in these patients.
|
24743019 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type 1 interferon (IFNα/β) has a significant role in establishing protection against virus infections.
|
24793964 |
2014 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In transfected bovine fetal fibroblasts, expression of intracellular IFN-α induced resistance to vesicular stomatitis virus infection, increased apoptosis, and induced the expression of double-stranded RNA-activated protein kinase gene (PKR) and the 2'-5'-oligoadenylate synthetase gene (2'-5' OAS), which are IFN-inducible genes with antiviral activity.
|
25004008 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In the absence of ADAR1, cellular RNA stimulates type I IFN production without viral infection or exogenous RNA stimulation.
|
25172485 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The IFN immune system plays an essential role in protecting the host against most viral infections.
|
25228491 |
2015 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our data suggest a role of the CBLB rs12487066 variant in the interactions of a genetic risk factor and IFN function during viral infections in MS.
|
25261476 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Innate immunity to viral infection involves induction of the type I IFN response; however, dysfunctional regulation of this pathway leads to inappropriate inflammation.
|
25401470 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Casein kinase II controls TBK1/IRF3 activation in IFN response against viral infection.
|
25810395 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Plasmacytoid dendritic cells (pDCs) are important early responders during systemic viral infections and, in some cases, are the sole producers of IFN-α.
|
25821224 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Consistently, AIP-deficient murine embryonic fibroblasts are highly resistant to virus infection because of increased production of IFNα/β.
|
25911105 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These results, which showed different IFN responses between human neuronal and glial cells after WNV or JEV infection, are expected to contribute to our understanding of the molecular mechanisms for neuropathology in these viral infections.
|
25920530 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings support a model, whereby allergic and antiviral responses are able to cross-regulate each other, as IgER cross-linking of pDCs prevents IFN-α/β production in response to viral infection.
|
26026068 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Some controversy exists around IL-27 and IFN-α, cytokines possibly released during bacterial or viral infections.
|
26324343 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type 1 interferons (IFNs; IFNα/β) mediate immunological host resistance to numerous viral infections, including herpes simplex virus type 1 (HSV-1).
|
26627457 |
2016 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Although zbtb16a/plzfa and zbtb16b/plzfb are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response.
|
26719025 |
2016 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Regulatory NLRs that augment pro-inflammatory pathways include nucleotide-binding oligomerization domain-containing protein 1 (NOD1) and NOD2, which have been shown to form a multiprotein complex termed the NODosome that significantly modulates IFN and NF-κB signalling following viral infection.
|
26763980 |
2016 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We have previously demonstrated that major vault protein (MVP) induces type I IFN production during viral infection; however, little is known about the role of MVP in proinflammatory responses.
|
26843330 |
2016 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Plasmacytoid dendritic cells (pDCs) are innate sensors of viral infections and important mediators of antiviral innate immunity through their ability to produce large amounts of IFN-α.
|
26871575 |
2016 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IFN regulatory factor 3 (IRF3) is the master transcription factor that controls IFN-I production via phosphorylation-dependent dimerization in most cell types in response to viral infections and various innate stimuli by pathogen-associated molecular patterns (PAMPs).
|
27045107 |
2016 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFNL polymorphisms influence regulatory pathways of cellular response to IFN and affect body iron balance in chronic hepatitis C virus infection.
|
27125837 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Inhibition of PP1 activity significantly increases IRF7 phosphorylation and IRF7-mediated IFN-α production in response to Newcastle disease virus (NDV) infection or Toll-like receptor 7 (TLR7) challenge, leading to impaired viral replication.
|
27469204 |
2016 |