Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This speculation was heightened by genetic evidence for the involvement of genomic imprinting in Beck-Wiedemann syndrome and Wilms' tumour, combined with the discovery that the IGF-II gene is imprinted.
|
9239720 |
1997 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The level of IGF2 expression was comparable with that of Wilms tumor.
|
9385942 |
1997 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Two other 11p15.5 loci, the linked and oppositely imprinted H19 and IGF2 genes, have been previously implicated in WT pathogenesis, and several of the tumors with persistent KIP2 mRNA expression and absence of KIP2 coding mutations showed full inactivation of H19.
|
9311733 |
1997 |
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Relaxation of imprinting at the insulin-like growth factor II (IFG-II)/H19 locus is a major mechanism involved in the onset of sporadic Wilms tumor and several other embryonal tumors.
|
9144243 |
1997 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Wilms' tumor (WT) is an embryonal renal malignancy, which overexpresses insulin-like growth factor II (IGF-II), a fetal mitogen.
|
9070652 |
1997 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that the increased expression of IGF2 in Wilms' tumor may be caused either by biallelic gene expression in LOI tumors from promoters P2-P4 and/or by a reversion to an earlier stage of development which is characterized by increased synthesis of this fetal growth factor.
|
8621549 |
1996 |
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have reported that the loss of the insulin-like growth factor-2 (IGF2) gene imprinting results in the deregulation of both IGF2 alleles, which may contribute to the onset of Wilms tumor.
|
8644850 |
1996 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We also examined p57KIP2 expression in the normal kidney and tongue of patients with Beckwith-Wiedemann syndrome (BWS), which predisposes to WT and also involves LOI of IGF2 and H19.
|
8971182 |
1996 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that alterations of IGF2 imprinting occurred in normal adjacent kidney tissue before tumorigenesis and that the IGF2 overexpression in Wilms' tumor tissue occurs through a loss of heterozygosity- or loss of imprinting-independent process.
|
8910385 |
1996 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Metanephric blastemal cells displayed characteristic vimentin and smooth muscle actin immunoreactivity and insulin-like growth factor II gene expression, whereas induced elements exhibited appropriate cytokeratin immunoreactivity and Wilms' tumor gene expression.
|
8642784 |
1996 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results showed that all nine cases of CMN (classic, mixed, and cellular) contained abundant IGF2 but not WT1 transcripts.
|
8634785 |
1995 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recently, loss of IGF2 imprinting has been reported in Wilms' tumor and in several other malignancies, and it has been suggested that biallelic expression of the gene leads to overexpression of IGF-II peptide and increased mitogenic activity.
|
7745016 |
1995 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Expression of the Wilms' tumor gene WT1 in human malignant mesothelioma cell lines and relationship to platelet-derived growth factor A and insulin-like growth factor 2 expression.
|
7535092 |
1995 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
H19, a putative growth suppressor, is oppositely imprinted to the neighboring insulin-like growth factor II (IGF2) gene and an up-regulation of IGF2 expression has been linked previously to a down-regulation of H19 expression in the progression to Wilms' tumor.
|
7866996 |
1995 |
Nephroblastoma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor.
|
7534414 |
1995 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This aberrant pattern of promoter imprinting, which was not detected in fetal kidney, provides further evidence that pathological relaxation of IGF2 imprinting is involved in the genesis of Wilms tumour.
|
7651739 |
1995 |
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Neuroblastoma, which is an embryonal tumor originating from neural crest-derived cells, occasionally occurs in individuals with the Beckwith-Wiedemann syndrome; Wilm's tumor and embryonal rhabdomyosarcoma occur even more frequently in the Beckwith-Wiedemann syndrome; and paternal uniparental disomy of H19 and IGF2 loci (chromosome 11p15) is present in the Beckwith-Wiedemann syndrome.
|
7614476 |
1995 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We show here, that in contrast to the situation in Wilms' tumor, H19 expression is not a prerequisite for maintaining a monoallelic IGF2 expression.
|
7624139 |
1995 |
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This frequency suggests that < or = 25% of the cases of Wilms tumor are due to the failure to imprint the maternal Igf-2 gene.
|
7847379 |
1995 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IGF-II expression is activated in several types of human neoplasms and an alteration of IGF-II imprinting has been described in Beckwith-Wiedemann syndrome and Wilms' tumor.
|
7981680 |
1994 |
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Using a combination of single-strand conformation polymorphism (SSCP) and polymerase chain reaction (PCR) sequencing techniques, no mutations were identified in the WT1 tumour-suppressor gene from the 11p13 region, but a novel polymorphism was identified in exon 1. mRNA expression studies using the insulin-like growth factor II (IGF-II) gene, located in 11p15, showed that there was no relaxation of imprinting at this locus.
|
7911030 |
1994 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour.
|
7920665 |
1994 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
H19 (RNA transcripts) and IGF2 are manifested in Wilms' tumor, rhabdomyosarcoma, immature ovarian teratoma and gestational trophoblastic diseases.
|
8073225 |
1994 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Paediatric neoplasms, like Wilm's tumor (WT) and rhabdomyosarcoma, often express IGF2 and H19.
|
7527480 |
1994 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A comparison of cultures derived from an epithelial-rich, classic Wilms' tumor and the anaplastic Wilm's tumor indicated that both lacked IGF-2 and WT-1 mRNA expression.
|
8178926 |
1994 |